Baseline profiles of ocular surface and tear dynamics after allogeneic hematopoietic stem cell transplantation in patients with or without chronic GVHD-related dry eye

Bone Marrow Transplantation

Volumn 45, Issue 6, 2010, Pages 1077-1083

  Wang, Y ^a,b   Ogawa, Y ^a   Dogru, M ^a,c   Tatematsu, Y ^a   Uchino, M ^a   Kamoi, M ^a   Okada, N ^a   Okamoto, S ^a   Tsubota, K ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b FUDAN UNIVERSITY   (China)

^c TOKYO DENTAL COLLEGE   (Japan)

Author keywords

allogeneic hematopoietic stem cell transplantation (HSCT); brush cytology; dry eye; impression cytology; meibomian gland; tear evaporation

Indexed keywords

ADULT; AGED; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; APLASTIC ANEMIA; ARTICLE; CELL DENSITY; CHRONIC GRAFT VERSUS HOST DISEASE; CLINICAL ARTICLE; CLINICAL EVALUATION; CONTROLLED STUDY; CORNEA REFLEX; DISEASE SEVERITY; DRY EYE; EYE EXAMINATION; FEMALE; GOBLET CELL; HUMAN; IMPRESSION CYTOLOGY; INFLAMMATORY CELL; MALE; MEIBOMIAN GLAND; MULTIPLE MYELOMA; MYELODYSPLASTIC SYNDROME; NONHODGKIN LYMPHOMA; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SCHIRMER TEST; SEBACEOUS GLAND DISEASE; TEAR FLOW; VITAL STAIN; ALLOTRANSPLANTATION; CASE CONTROL STUDY; CHRONIC DISEASE; CLINICAL TRIAL; COMPLICATION; CONJUNCTIVA; CONJUNCTIVITIS; GRAFT VS HOST DISEASE; HEMATOLOGIC DISEASES; HEMATOPOIETIC STEM CELL TRANSPLANTATION; LACRIMAL FLUID; MIDDLE AGED; PATHOLOGY; XEROPHTHALMIA; YOUNG ADULT;

ADULT; CASE-CONTROL STUDIES; CHRONIC DISEASE; CONJUNCTIVA; CONJUNCTIVITIS; FEMALE; GOBLET CELLS; GRAFT VS HOST DISEASE; HEMATOLOGIC DISEASES; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; MALE; MIDDLE AGED; TEARS; TRANSPLANTATION, HOMOLOGOUS; XEROPHTHALMIA; YOUNG ADULT;

EID: 77954865427     PISSN: 02683369     EISSN: 14765365     Source Type: Journal    
DOI: 10.1038/bmt.2009.312     Document Type: Article

References (30)

1. Filipovich AH, Weisdorf D, Pavletic S, Socie G, Wingard JR, Lee SJ et al. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report. Biol Blood Marrow Transplant 2005; 11: 945-956. (Pubitemid 41754712)
2. Ogawa Y, Okamoto S, Wakui M, Watanabe R, Yamada M, Yoshino M et al. Dry eye after hematopoietic stem cell transplantation. Br J Ophthalmol 1999; 83: 1125-1130.
3. Ogawa Y, Okamoto S, Mori T, Yamada M, Mashima Y, Watanabe R et al. Autologous serum eye drops for the treatment of severe dry eye in patients with chronic graft-versus-host disease. Bone Marrow Transplant 2003; 31: 579-583.
4. Ogawa Y, Yamazaki K, Kuwana M, Mashima Y, Nakamura Y, Ishida S et al. A significant role of stromal fibroblasts in rapidly progressive dry eye in patients with chronic GVHD. Invest Ophthalmol Vis Sci 2001; 42: 111-119.
5. Ogawa Y, Kuwana M, Yamazaki K, Mashima Y, Yamada M, Mori T et al. Periductal area as the primary site for T-cell activation in lacrimal gland chronic graft-versus-host disease. Invest Ophthalmol Vis Sci 2003; 44: 1888-1896.
6. Rojas B, Cuhna R, Zafirakis P, Ramirez JM, Lizan-garciia M, Zhao T et al. Cell populations and adhesion molecules expression in conjunctiva before and after bone marrow transplantation. Exp Eye Res 2005; 81: 313-325.
7. Singh R, Joseph A, Umapathy T, Tint NL, Dua HS. Impression cytology of the ocular surface. Br J Ophthalmol 2005; 89: 1655-1659.
8. Dogru M, Okada N, Asano-Kato N, Tanaka M, Igarashi A, Takano Y et al. Atopic ocular surface disease: implications on tear function and ocular surface mucins. Cornea 2005; 24: S18-S23.
9. Miyoshi T, Fukagawa K, Shimmura S, Fujishima H, Takano Y, Takamura E et al. Interleukin-8 concentrations in conjunctival epithelium brush cytology samples correlate with neutrophil, eosinophil infiltration, and corneal damage. Cornea 2001; 20: 743-747.
10. Aronni S, Cortes M, Sacchetti M, Lambiase A, Micera A, Sgrulletta R et al. Upregulation of ICAM-1 expression in the conjunctiva of patients with chronic graft-versus-host disease. Eur J Ophthalmol 2006; 16: 17-23.
11. Lemp MA. Report of the national eye institute/industry workshop on clinical trials in dry eyes. CLAO J 1995; 21: 221-232.
12. Report of the International Dry Eye Work Shop. Ocul Surf 2007; 5: 75-92.
13. Tsubota K. The importance of the Schirmer test with nasal stimulation test. Am J Ophthalmol 1991; 111: 106-108.
14. Toda I, Tsubota K. Practical double vital staining for ocular surface evaluation. Cornea 1993; 12: 366-368.
15. Dogru M, Asano-Kato N, Tanaka M, Igarashi A, Shimmura S, Shimazaki J et al. Ocular surface and MUC5AC alterations in atopic patients with corneal shield ulcers. Curr Eye Res 2005; 30: 897-908.
16. Shimazaki J, Goto E, Ono M, Shimmura S, Tsubota K. Meibomian gland dysfunction in patients with Sjogren syndrome. Ophthalmology 1998; 105: 1485-1488.
17. Goto E, Endo K, Suzuki A, Fujikura Y, Matsumoto Y, Tsubota K. Tear evaporation dynamics in normal subjects and subjects with obstructive meibomian gland dysfunction. Invest Ophthalmol Vis Sci 2003; 44: 533-539.
18. Xu KP, Yagi Y, Tsubota K. Decrease in corneal sensitivity and change in tear function in dry eye. Cornea 1996; 15: 235-239.
19. Bourcier T, Acosta MC, Borderie V, Borrá s F, Gallar J, Bury T et al. Decreased corneal sensitivity in patients with dry eye. Invest Ophthalmol Vis Sci 2005; 46: 2341-2345.
20. Nelson JD. Impression cytology. Cornea 1988; 7: 71-81.
21. McCulley JP, Shine WE. The lipid layer of tears: dependent on meibomian gland function. Exp Eye Res 2004; 78: 361-365.
22. Mathers W. Evaporation from the ocular surface. Exp Eye Res 2004; 78: 389-394.
23. Tseng SC. Staging of conjunctival squamous metaplasia by impression cytology. Ophthalmology 1985; 92: 728-733.
24. Aragona P, Ferreri G, Micali A, Puzzolo D. Morphological changes of the conjunctival epithelium in contact lens wearers evaluated by impression cytology. Eye 1998; 12: 461-466.
25. Tseng SC, Hirst LW, Maumenee AE, Kenyon KR, Sun TT, Green WR. Possible mechanisms for the loss of goblet cells in mucin-deficient disorders. Ophthalmology 1984; 91: 545-552.
26. Kinoshita S, Kiorpes TC, Friend J, Thoft RA. Goblet cell density in ocular surface disease. A better indicator than tear mucin. Arch Ophthalmol 1983; 101: 1284-1287.
27. Gipson IK, Hori Y, Argueso P. Character of ocular surface mucins and their alteration in dry eye disease. Ocul Surf 2004; 2: 131-147.
28. Stern ME, Pflugfelder SC. Inflammation in dry eye. Ocul Surf 2004; 2: 124-130.
29. Tsubota K, Fujihara T, Saito K, Takeuchi T. Conjunctival epithelium expression of HLA-DR in dry eye patients. Ophthalmologica 1999; 213: 16-19.
30. Rolando M, Barabino S, Mingari C, Moretti S, Giuffrida S, Calabria G. Distribution of conjunctival HLA-DR expression and the pathogenesis of damage in early dry eyes. Cornea 2005; 24: 951-954.