A multi-technique approach using LC-NMR, LC-MS, semi-preparative HPLC, HR-NMR and HR-MS for the isolation and characterization of low-level unknown impurities in GW876008, a novel corticotropin-release factor 1 antagonist

Journal of Pharmaceutical and Biomedical Analysis

Volumn 53, Issue 3, 2010, Pages 517-525

  Provera, Stefano ^a   Rovatti, Luca ^a   Turco, Lucilla ^a   Mozzo, Sebastiano ^a   Spezzaferri, Alberto ^a   Bacchi, Sergio ^a   Ribecai, Arianna ^a   Guelfi, Simone ^a   Mingardi, Anna ^a   Marchioro, Carla ^a   Papini, Damiano ^a  

^a GSK   (Italy)

Author keywords

CRF1 antagonists; HPLC; HR MS; HR NMR; LC NMR

Indexed keywords

GW 876008;

ARTICLE; DRUG IMPURITY; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; LIQUIG CHROMATOGRAPHY MASS SPECTROMETRY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

BICYCLO COMPOUNDS, HETEROCYCLIC; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CONTAMINATION; MAGNETIC RESONANCE SPECTROSCOPY; PYRAZOLES; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 77954860532     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.06.012     Document Type: Article

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