Change of CCR7 and CD45RA after blocking of Kv1.3 potassium channel of CD4+ T lymphocytes in multiple sclerosis

National Medical Journal of China

Volumn 88, Issue 27, 2008, Pages 1896-1899

  Ren, Xiao Tun ^a   Wu, Wei Ping ^a   Xu, Quan Gang ^a   Huang, De Hui ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Antigens, CD45; Kv1.3 potassium channel; Multiple sclerosis; Patossium channel blockers; Receptors, chemokine

Indexed keywords

CD3 ANTIGEN; CD4 ANTIBODY; CD4 ANTIGEN; CD45RA ANTIGEN; CHEMOKINE RECEPTOR CCR7; MYELIN; POTASSIUM CHANNEL KV1.3; CALCIUM CHANNEL BLOCKING AGENT; CCR7 PROTEIN, HUMAN; CD45 ANTIGEN; COELENTERATE VENOM;

ANTIGEN EXPRESSION; ARTICLE; CD4+ T LYMPHOCYTE; CELL ISOLATION; CLINICAL ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; MULTIPLE SCLEROSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; T LYMPHOCYTE; ADULT; BIOSYNTHESIS; BLOOD; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; MALE; METABOLISM; MIDDLE AGED;

ADULT; ANTIGENS, CD45; CALCIUM CHANNEL BLOCKERS; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CNIDARIAN VENOMS; FEMALE; FLOW CYTOMETRY; HUMANS; KV1.3 POTASSIUM CHANNEL; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; RECEPTORS, CCR7; YOUNG ADULT;

EID: 77954848007     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Beeton C, Wulff H, Singh S, et al. A novel fluorescent toxin to detect and investigate Kv1.3 Channel up-regulation in chronically activated T lymphocytes. Biol chem, 2003, 278: 9928-9937.
2. + T cells in patients with chronic beryllium disease. J Clin Invest, 2002, 110: 1473-1482.
3. Norton RS, Pennington MW, Wulff H. Potassium channel blockade by the sea anemone toxin SHK for the treatment of multiple sclerosis and other autoimmune diseases. Curr Med Chem, 2004, 11: 3041-3052.
4. Blander JM, Sant' Angelo DR, Metz D, et al. A pool of central memory-like CD4 T cells contains effector memory precursors. J Immunol, 2003, 170: 2940-2948. (Pubitemid 36302165)
5. --T-cell effector function and migration following viral infection. J Virol, 2003, 77: 4004-4014.
6. Chandy KG, DeCoursey TE, Calahan MD, et al. Voltage-gated potassium channels are required for human T lymphocyte activation. J Exp Med, 1984, 160: 369-385.
7. Lin CS, Boltz RC, Blake JT, et al. Voltage-gated potassium channels regulate calcium-dependent pathways involved in human T lymphocyte activation. J Exp Med, 1993, 177: 637-645.
8. + channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis. PNAS, 2001, 98: 1394-1397.
9. Rus H, Pardo CA, Hu L, et al. The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain. PNAS, 2005, 102: 11094-11099.