Immunophenotypic features of granulocytes, monocytes, and blasts in myelodysplastic syndromes

Korean Journal of Laboratory Medicine

Volumn 30, Issue 2, 2010, Pages 97-104

  Moon, Hee Won ^a   Huh, Jung Won ^b   Lee, Miae ^b   Hong, Ki Sook ^b   Chung, Wha Soon ^b  

^a Konkuk University School of Medicine   (South Korea)

^b Ewha Womans University School of Medicine   (South Korea)

Author keywords

Blast; Granulocyte; Immunophenotyping; MDS; Monocyte

Indexed keywords

CD45 ANTIGEN; CD56 ANTIGEN; MEMBRANE METALLOENDOPEPTIDASE;

ADOLESCENT; ADULT; AGED; ARTICLE; BONE MARROW CELL; CELL LINEAGE; CHILD; CLASSIFICATION; CYTOLOGY; DIFFERENTIAL DIAGNOSIS; FEMALE; FLOW CYTOMETRY; GRANULOCYTE; HUMAN; IMMUNOPHENOTYPING; LEUKEMIA; MALE; METABOLISM; MIDDLE AGED; MONOCYTE; MYELODYSPLASTIC SYNDROME; PATHOLOGY; PHENOTYPE; PRESCHOOL CHILD;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD45; ANTIGENS, CD56; BONE MARROW CELLS; CELL LINEAGE; CHILD; CHILD, PRESCHOOL; DIAGNOSIS, DIFFERENTIAL; FEMALE; FLOW CYTOMETRY; GRANULOCYTES; HUMANS; IMMUNOPHENOTYPING; LEUKEMIA; MALE; MIDDLE AGED; MONOCYTES; MYELODYSPLASTIC SYNDROMES; NEPRILYSIN; PHENOTYPE;

EID: 77954845847     PISSN: 15986535     EISSN: None     Source Type: Journal    
DOI: 10.3343/kjlm.2010.30.2.97     Document Type: Article

References (26)

1. Kussick SJ, Fromm JR, Rossini A, Li Y, Chang A, Norwood TH, et al. Four-color flow cytometry shows strong concordance with bone marrow morphology and cytogenetics in the evaluation for myelodysplasia. Am J Clin Pathol 2005;124:170-81.
2. Ogata K, Kishikawa Y, Satoh C, Tamura H, Dan K, Hayashi A. Diagnostic application of flow cytometric characteristics of CD34+ cells in low-grade myelodysplastic syndromes. Blood 2006;108:1037-44.
3. Ogata K, Nakamura K, Yokose N, Tamura H, Tachibana M, Taniguchi O, et al. Clinical significance of phenotypic features of blastsin patients with myelodysplastic syndrome. Blood 2002;100:3887-96.
4. Xu D, Schultz C, Akker Y, Cannizzaro L, Ramesh KH, Du J, et al. Evidence for expression of early myeloid antigens in mature, non-blast myeloid cells in myelodysplasia. Am J Hematol 2003;74:9-16.
5. Wells DA, Benesch M, Loken MR, Vallejo C, Myerson D, Leisenring WM, et al. Myeloid and monocytic dyspoiesis as determined by flow cytometric scoring in myelodysplastic syndrome correlates with the IPSS and with outcome after hematopoietic stem cell transplantation. Blood 2003;102:394-403.
6. Stetler-Stevenson M, Arthur DC, Jabbour N, Xie XY, Molldrem J, Barrett AJ, et al. Diagnostic utility of flow cytometric immunophenotyping in myelodysplastic syndrome. Blood 2001;98:979-87.
7. Wood BL. Flow cytometric diagnosis of myelodysplasia and myeloproliferative disorders. J Biol Regul Homeost Agents 2004;18:141-5.
8. Swerdlow SH, Campo E, et al. eds. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon: IARC Press, 2008.
9. Casasnovas RO, Slimane FK, Garand R, Faure GC, Campos L, Deneys V, et al. Immunological classification of acute myeloblastic leukemias: relevance to patient outcome. Leukemia 2003;17:515-27.
10. Elghetany MT. Diagnostic utility of flow cytometric immunophenotyping in myelodysplastic syndrome. Blood 2002;99:391-2.
11. Chang CC and Cleveland RP. Decreased CD10-positive mature granulocytes in bone marrow from patients with myelodysplastic syndrome. Arch Pathol Lab Med 2000;124:1152-6.
12. Cherian S, Moore J, Bantly A, Vergilio JA, Klein P, Luger S, et al. Peripheral blood MDS score: a new flow cytometric tool for the diagnosis of myelodysplastic syndromes. Cytometry B Clin Cytom 2005; 64:9-17.
13. Del Canizo MC, Fernandez ME, Lopez A, Vidriales B, Villaron E, Arroyo JL, et al. Immunophenotypic analysis of myelodysplastic syndromes. Haematologica 2003;88:402-7.
14. Orfao A, Ortuno F, de Santiago M, Lopez A, San Miguel J. Immunophenotyping of acute leukemias and myelodysplastic syndromes. Cytometry A 2004;58:62-71.
15. Ribeiro E, Matarraz Sudon S, de Santiago M, Lima CS, Metze K, Giralt M, et al. Maturation-associated immunophenotypic abnormalities in bone marrow B-lymphocytes in myelodysplastic syndromes. Leuk Res 2006;30:9-16.
16. Kussick SJ and Wood BL. Using 4-color flow cytometry to identify abnormal myeloid populations. Arch Pathol Lab Med 2003;127: 1140-7.
17. Cermak J, Belickova M, Krejcova H, Michalova K, Zilovcova S, Zemanova Z, et al. The presence of clonal cell subpopulations in peripheral blood and bone marrow of patients with refractory cytopenia with multilineage dysplasia but not in patients with refractory anemia may reflect a multistep pathogenesis of myelodysplasia. Leuk Res 2005;29:371-9.
18. Dunphy CH, Orton SO, Mantell J. Relative contributions of enzyme cytochemistry and flow cytometric immunophenotyping to the evaluation of acute myeloid leukemias with a monocytic component and of flow cytometric immunophenotyping to the evaluation of absolute monocytoses. Am J Clin Pathol 2004;122:865-74.
19. Lorand-Metze I, Ribeiro E, Lima CS, Batista LS, Metze K. Detection of hematopoietic maturation abnormalities by flow cytometry in myelodysplastic syndromes and its utility for the differential diagnosis with non-clonal disorders. Leuk Res 2007;31:147-55.
20. Pirruccello SJ, Young KH, Aoun P. Myeloblast phenotypic changes in myelodysplasia. CD34 and CD117 expression abnormalities are common. Am J Clin Pathol 2006;125:884-94.
21. Terstappen LW, Safford M, Loken MR. Flow cytometric analysis of human bone marrow. III. Neutrophil maturation. Leukemia 1990; 4:657-63.
22. Mann KP, DeCastro CM, Liu J, Moore JO, Bigner SH, Traweek ST. Neural cell adhesion molecule (CD56)-positive acute myelogenous leukemia and myelodysplastic and myeloproliferative syndromes. Am J Clin Pathol 1997;107:653-60.
23. Schlesinger M, Silverman LR, Jiang JD, Yagi MJ, Holland JF, Bekesi JG. Analysis of myeloid and lymphoid markers on the surface and in the cytoplasm of mononuclear bone marrow cells in patients with myelodysplastic syndrome. J Clin Lab Immunol 1996;48:149-66.
24. Malcovati L, Della Porta MG, Lunghi M, Pascutto C, Vanelli L, Travaglino E, et al. Flow cytometry evaluation of erythroid and myeloid dysplasia in patients with myelodysplastic syndrome. Leukemia 2005;19:776-83.
25. Loken MR, van de Loosdrecht A, Ogata K, Orfao A, Wells DA. Flow cytometry in myelodysplastic syndromes: report from a working conference. Leuk Res 2008;32:5-17.
26. Connelly JC, Chambless R, Holiday D, Chittenden K, Johnson AR. Up-regulation of neutral endopeptidase (CALLA) in human neutrophils by granulocyte-macrophage colony-stimulating factor. J Leukoc Biol 1993;53:685-90.