Relationship between expression of inhibitory killer cell immunoglobulin-like receptor HLA-Cw ligand and susceptibility to inflammatory bowel disease

National Medical Journal of China

Volumn 88, Issue 44, 2008, Pages 3108-3111

  Zhang, Hui Xia ^a   Li, Ji Chang ^b   Liu, Zhan Ju ^b  

^a ZHENGZHOU UNIVERSITY   (China)

^b NONE

Author keywords

Colitis, ulcerative; Crohn disease; HLA antigens; Immunoglobulins

Indexed keywords

HLA C ANTIGEN; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 2DL1; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 2DL3;

ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CROHN DISEASE; DISEASE PREDISPOSITION; ENTERITIS; GENE FREQUENCY; HUMAN; MAJOR CLINICAL STUDY; PHENOTYPE; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; ADOLESCENT; ADULT; AGED; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; FEMALE; GENE EXPRESSION; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; IMMUNOLOGY; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL;

ADOLESCENT; ADULT; AGED, 80 AND OVER; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HLA-C ANTIGENS; HUMANS; INFLAMMATORY BOWEL DISEASES; MIDDLE AGED; PHENOTYPE; RECEPTORS, KIR2DL1; RECEPTORS, KIR2DL3;

EID: 77954810144     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. van Heel DA, Fisher SA, Kirby A, et al. Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs. Hum Mol Genet, 2004, 13: 763-770.
2. Parham P. MHC class I molecules and KIRs in human history, health and survival. Nat Rev Immunol, 2005, 5: 201-214. (Pubitemid 40364822)
3. Khakoo SI, Thio CL, Martin MP, et al. HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection. Science, 2004, 305: 872-874.
4. Martin MP, Gao X, Lee JH, et al. Epislatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Nat Genet, 2002, 31: 429-434.
5. Nelson GW, Martin MP, Gladman D, et al. Cutting edge: heterozygote advantage in autoimmune disease: hierarchy of protection/susceptibility conferred by HLA and killer Ig-like receptor combinations in psoriatic arthritis. J Immunol, 2004, 173: 4273-4276.
6. Jones DC, Edgar RS, Ahmad T, et al. Killer Ig-like receptor (KIR) genotype and HLA ligand combinations in ulcerative colitis susceptibility. Genes Immun, 2006, 7: 576-582.
7. Leung W, Iyengar R, Turner V, et al. Determinants of the antileukemia effects of allogeneic NK cells. J Immunol, 2004, 172: 644-650.
8. Naumova E, Mihaylova A, Stoitchkov K, et al. Genetic polymorphism of NK receptors and their ligands in melanoma patients: prevalence of inhibitory over activating signals. Cancer Immunol Immunother, 2005, 54: 172-178.
9. van der Slik AR , Koeleman BP, Verduijn W, et al. KIR in type 1 diabetes: disparate distribution of activating and inhibitory natural killer cell receptors in patients versus HLA-matched control subjects. Diabetes, 2003, 52: 2639-2642.
10. Pazmany L. Do NK cells regulate human autoimmunity? Cytokine, 2005, 32: 76-78.
11. van der Slik AR, Alizadeh BZ, Kocleman BP, et al. Modelling KIR-HLA genotype disparities in type 1 diabetes. Tissue Antigens, 2007, 69: 101-105.
12. Hiby SE, Walker JJ, O'Shaughnessy KM, et al. Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success. J Exp Med, 2004, 200: 957-965.