Benzodiazepine tapering: A prospective study

Nordic Journal of Psychiatry

Volumn 64, Issue 4, 2010, Pages 273-282

  Vikander, Britt ^a   Koechling, Ulrike M ^a   Borg, Stefan ^a   Tnne, Ulla ^a   Hiltunen, Arto J ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KARLSTAD UNIVERSITY   (Sweden)

Author keywords

Benzodiazepines; Symptoms; Tapering

Indexed keywords

ALPRAZOLAM; BENZODIAZEPINE; DIAZEPAM; FLUNITRAZEPAM; LORAZEPAM; NEUROLEPTIC AGENT; NITRAZEPAM; NON PRESCRIPTION DRUG; OXAZEPAM; PRESCRIPTION DRUG; BENZODIAZEPINE DERIVATIVE; HYPNOTIC SEDATIVE AGENT;

ADULT; AGITATION; ANXIETY DISORDER; APPETITE DISORDER; ARTICLE; CLINICAL ARTICLE; COMPREHENSIVE PSYCHOPATHOLOGICAL RATING SCALE; CONCENTRATION LOSS; CONTROLLED STUDY; DEPERSONALIZATION; DEPRESSION; DISEASE SEVERITY; DISTRACTIBILITY; DIVORCE; DRUG DEPENDENCE; DRUG DOSE REDUCTION; DRUG MEGADOSE; DRUG USE; DRUG WITHDRAWAL; EDUCATIONAL STATUS; FATIGUE; FEMALE; HEADACHE; HEARING DISORDER; HOSTILITY; HUMAN; HYPOCHONDRIASIS; INSOMNIA; LASSITUDE; LONELINESS; LOW DRUG DOSE; MALE; MARRIAGE; MEDICAL LEAVE; MEMORY DISORDER; MENTAL INSTABILITY; MOOD DISORDER; MORBIDITY; MUSCLE TONE; NEWCASTLE ANXIETY AND DEPRESSION DIAGNOSTIC INDEX; PANIC; PATIENT REFERRAL; PERSECUTORY DELUSION; PESSIMISM; PHOBIA; PRESCRIPTION; PROSPECTIVE STUDY; PSYCHOLOGIC TEST; PSYCHOLOGICAL RATING SCALE; SAMPLE SIZE; SELF ESTEEM; SELF REPORT; SENSORY DYSFUNCTION; SLEEP DISORDER; SMELLING DISORDER; SPEECH DISORDER; SUICIDAL BEHAVIOR; SYMPTOMATOLOGY; TASTE DISORDER; TOXICOLOGICAL PARAMETERS; TREATMENT DURATION; VISUAL DISORDER; WITHDRAWAL SYNDROME; ADOLESCENT; CHEMICALLY INDUCED; DRUG ADMINISTRATION; FOLLOW UP; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; SUBSTANCE WITHDRAWAL SYNDROME; YOUNG ADULT;

ADOLESCENT; ADULT; ANXIETY DISORDERS; BENZODIAZEPINES; DEPRESSIVE DISORDER; DRUG ADMINISTRATION SCHEDULE; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPNOTICS AND SEDATIVES; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; SUBSTANCE WITHDRAWAL SYNDROME; YOUNG ADULT;

EID: 77954792583     PISSN: 08039488     EISSN: 15024725     Source Type: Journal    
DOI: 10.3109/08039481003624173     Document Type: Article

References (42)

1. Ashton H. The diagnosis and management oi benzodiazepine dependence. Curr Opin Psychiatry 2005;18:249-255
2. Ashton H, Golding JF. Tranquillisers: Prevalence, predictors and possible consequences. Data from a large United Kingdom survey. Br J Addict 1989;84:541-546
3. Gold MS, Miller NS, Stennie K, Populla-Vardi C. Epidemiology of benzodiazepine use and dependence. Psychiat Ann 1995;25:146-148
4. Lader M. History of benzodiazepine dependence. J Subst Abuse Treat 1991;8:53-59
5. Ladewig D. Abuse of benzodiazepines in Western European society-Incidence and prevalence, motives, drug acquisition. Pharamcopsychiatry 1983;16:103-106
6. Balddessarini RJ. Drugs and the treatment of psychiatric disorders. In: Goodman Gilman A, Rall TW, Nies AS, Taylor P, editors. The pharmacological basis of therapeutics, 8th edition. New York: Pergamon Press; 1991. p. 383-435.
7. Balter MB, Uhlenhulth EH. The beneficial and adverse effects of hypnotics. J Clin Psychiat 1991;52 Suppl 7:16-23.
8. Ashton H. Protracted withdrawal syndromes from benzodiazepines. J Subst Abuse Treat 1991;8:19-28.
9. Ashton H. Toxicity and adverse consequences of benzodiazepine use. Psychiat Ann 1995;25:158-165
10. Lader M, Morton S. The practical business of treatment-17: Benzodiazepine problems. Br J Addict 1991;86:823-828
11. Rall TW. Hypnotics and sedatives; ethanol. In: Goodman Gilman A, Rall TW, Nies AS, Taylor P, editors. The pharmacological basis of therapeutics, 8th edition. New York: Pergamon Press; 1991. 345-382
12. Miller NS, Gold MS. Abuse, addiction, tolerance and dependence to benzodiazepines in medical and nonmedical populations, Am J Drug Alc Abuse 1991;17:27-37.
13. O'Brien CP. Benzodiazepine use, abuse, and dependence. J Clin Psychiatry 2005;66 Suppl 2:28-33.
14. Lader M, Russell J. Note on a report from the Mental Health Foundation Guidelines for the prevention and treatment of benzodiazepine dependence: Summary of a report from the Mental Health Foundation. Addiction 1993;88:1707-1708
15. Rickels K, Schweizer E, Weiss RN, Zavodnick S. Maintenance drug treatment for panic disorder. 11. Short- and long-term outcomes after drug taper. Arch Gen Psychiat 1993;50:61-68
16. Roach JD, Meisch RA. Findings from self-administration research on addiction potential of benzodiazepines. Psychiat Ann 1995;25:153-157
17. Schweizer E, Rickels K, Warren GC, Greenblatt DJ. Carbamazepine treatment in patients discontinuing long-term benzodiazepine therapy. Arch Gen Psychiat 1991;48:448-452
18. Fontaine R, Chouinard G, Annable L. Rebound anxiety in anxious patients after abrupt withdrawal of benzodiazepine treatment. Am J Psychiat 1984;141:848-852
19. Holton A, Riley P, Tyrer P. Factors predicting long-term outcome after chronic benzodiazepine therapy. J Affect Disord 1992;24: 245-252
20. Miller N-S. Liability and efficacy from long-term use of benzodiazepines. Documentation and interpretation. Psychiat Ann 1995;25:166-173
21. Rickels K, Case WG, Schweizer E, Garcia-Espanan F, Fridman R. Long-term benzodiazepine users 3 years after participation in a discontinuation program. Am J Psychiat 1991;148:757-761
22. Higgit A, Fonngy P, Poone B, Shine P. The prolonged benzodiazepine withdrawal syndrome: Anxiety or hysteria? Acta Psychiat Scand 1990;82:165-168
23. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 3rd edition-revised. Washington, DC: The American Psychiatric Association; 1987.
24. Asberg M, Perris C, Schalling D, Sedvall G. The comprehensive psychopathological rating scale: Development and applications of a psychiatric rating scale. Acta Psychiat Scand 1978;271 Suppl 1:5-69.
25. Axelsson R, Nilsson A, Christensson E, Bjork A. Effects of amperozide in schizophrenia, an open study of a potent 5-HT2 receptor antagonist. Psychopharmacology 1991;104:287-292
26. Bertschy G, Viel JF, Ahyi RG. Depression in Benin: An assessment using the Comprehensive Psychopathological Rating Seale and the principal component analysis. J Affect Disord 1992;25:173-180
27. Nilsson A, Axelsson R. Lithium discontinuers. 11. Therapeutic outcome. Acta Psychiat Scand 1991;84:78-82.
28. Goekoop JG, Knoppert-Van der Klein EAM, Hoeksema T, Klinkhamer RA, Van Gaalen HAE, Van der Velde EA. The interrater reliability of a Dutch version of the Comprehensive Psychopathological Rating Scale. Acta Psychiat Scand 1991;83:202-205
29. Carney MWP, Roth M, Garside RF. The diagnosis of depressive syndromes and the prediction of ECT response. Br J Psychiat 1965;11:659-674
30. Davidson J, Pelton S, Krishnana KRR, MeLeod M, Raft D, Miller R, et al. An assessment of the Newcastle Anxiety Depression Index. Acta Psychiat Scand 1986;733:533-543
31. Zimmerrnan M, Pfohl B, Stangi D, Coryell W. An American validation study of the Newcastle Diagnostic Scale. Br J Psychiat 1986;149:627-630
32. Harzer K, Barchet R. Analyse von Benzodiazepinen und deren Hydrolysenprodukte, den Benzophenomen, durch Hochdruckfluessigkeits - chromatographie in umgekehrter Phase und ihre Anwendung auf biologisches Materia. J Chromatography 1977;132:83-90.
33. Schuetz H. Sereening von Benzodiazepinen. Aerztliches Laborator 1982;28:117-132
34. Tonne U, Hiltunen AJ, Vikander B, Engelbrektsson K, Bergman H, Bergman L, et al. Neuropsychological changes during steady-state drug use, withdrawal and abstinence in primary benzodiazepine- dependent patients, Acta Psychiat Scand 1995;91:299-304.
35. McGregor C, Machin A, White JM. In-patient benzodiazepine withdrawal: Comparison of fixed and symptom-triggered taper methods. Drug Alcohol Rev 2003;22:175-180
36. Vicens C, Fiol F, Llobera J, Campoamor F, Mateu C, Alegret S, et al. Withdrawal from long-term benzodiazepine use: Randomised trial in family practice. Br J Gen Pract 2006;56:958-963
37. Ashton H. Benzodiazepine withdrawal: An unfinished story. Br Med J 1984;288:1135-1140
38. Tonne U, Hiltunen AJ, Engelbrektsson K, Bjorwell H, Vikander B, Borg S. Personality characteristics in primary benzodiazepine-dependent patients: Comparison with controls and polydrug users. Pers Ind Diff 1998;24:797-804.
39. Feldman RS, Quenzer LF. Fundamentals of neuropharmacology. Sunderland, MA: Sinauer Associates Inc.; 1984. p. 315-465.
40. Tyrer P, Owen R, Dawling S. Gradual withdrawal of diazepam after long-term therapy. Lancet 1983;1:1402-1406
41. Busto U, Sellers EM, Naranjo CA, Cappell H, Sanches-Craig M, Sykora K. Withdrawal reaction after long-term therapeutic use of benzodiazepines. New Engl J Med 1986;315:854-859
42. Busto U, Sellers EM. Pharmacologic aspects of benzodiazepine tolerance and Dependence. J Subst Abuse Treat 1991;8:29-33.