Acute cholestatic hepatitis along with agranulocytosis: A rare side effect of carbimazole

Annals of African Medicine

Volumn 9, Issue 2, 2010, Pages 102-104

  Jain, Karun ^a   Chakrapani, M ^b   Smitha, K ^b  

^a JSS MEDICAL COLLEGE   (India)

^b KASTURBA MEDICAL COLLEGE   (India)

Author keywords

Agranulocytosis; carbimazole; cholestatic hepatitis; hyperthyroidism

Indexed keywords

CARBIMAZOLE; CEFTRIAXONE; CLOXACILLIN; FAMCICLOVIR; ANTITHYROID AGENT;

ADULT; AGRANULOCYTOSIS; APLASTIC ANEMIA; ARTICLE; CASE REPORT; CHOLESTATIC HEPATITIS; CLINICAL FEATURE; DISEASE COURSE; DRUG WITHDRAWAL; FEMALE; FEVER; HUMAN; HYPERTHYROIDISM; MACULOPAPULAR RASH; VASCULITIS; CHEMICALLY INDUCED; CHOLESTASIS; COMPLICATION; MIDDLE AGED; TOXIC HEPATITIS;

AGRANULOCYTOSIS; ANTITHYROID AGENTS; CARBIMAZOLE; CHOLESTASIS; DRUG-INDUCED LIVER INJURY; FEMALE; HUMANS; HYPERTHYROIDISM; MIDDLE AGED;

EID: 77954786638     PISSN: 15963519     EISSN: 09755764     Source Type: Journal    
DOI: 10.4103/1596-3519.64752     Document Type: Article

References (10)

1. Cooper DS. Antithyroid drugs. N Engl J Med 2005;352: 905-917
2. Vilchez FJ, Torres I, Garcia-Valero A, Lopez-Tinoco C, de Los Santos A, Aguilar-Diosdado M. Concomitant agranulocytosis and hepatotoxicity after treatment with carbimazole. Ann Pharmacother 2006;40:2059-2063
3. Franklyn JA. The management of Hyperthyroidism. N Engl J Med 1994;330:1731-1738
4. Woeber KA. Methimazole-induced hepatotoxicity. Endocr Pract 2002;8:222-224
5. Blom H, Stolk J, Schreuder HB, von Blomberg-van der Flier M. A case of Carbimazole induced intra hepatic cholestasis. An immune mediated reaction? Arch Intern Med 1985;145:1513-1515
6. Sadoul JL, Canivet B, Freychet P. Toxic hepatitis induced by anti thyroid drugs: Four cases including one with cross reactivity between Carbimazole and benzylthiouracil. Eur J Med 1993;2:473-477
7. Eigtved A, Bregengard C, Poulsen S. Severe adverse effects of low dose Carbimazole treatment in hyperthyroidism. A retrospective study of 476 patients. Ugeskr Laeger 1989;151:23-25
8. Schwab GP, Wetscher GJ, Vogl W, Redmond E. Methimazole - induced cholestatic liver injury, mimicking sclerosing cholangitis. Langenbecks Arch Chir 1996;381:225-227
9. McDonnell ME, Braverman LE. Drug-related hepatotoxicity. N Engl J Med 2006;354:2191-2193
10. Dai W, Zhang J, Zhan Z, Xu B, Jin H. Retrospective analysis of 18 cases with agranulocytosis induced by antithyroid drugs. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 1998;20:226-229