Effect of modafinil on impairments in neurobehavioral performance and learning associated with extended wakefulness and circadian misalignment

Neuropsychopharmacology

Volumn 35, Issue 9, 2010, Pages 1910-1920

  Grady, Scott ^a   Aeschbach, Daniel ^a   Wright, Kenneth P ^a,b   Czeisler, Charles A ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

circadian misalignment; forced desynchrony; modafinil; neurobehavioral performance; sleep homeostasis

Indexed keywords

MODAFINIL; PLACEBO; BENZHYDRYL DERIVATIVE; NEUROPROTECTIVE AGENT;

ADULT; ALERTNESS; ARTICLE; BEHAVIOR; CIRCADIAN RHYTHM; CLINICAL TRIAL; COGNITION; CONTROL GROUP; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HUMAN; LEARNING; MALE; PARALLEL DESIGN; POLYSOMNOGRAPHY; PRIORITY JOURNAL; PSYCHOMOTOR PERFORMANCE; RANDOMIZED CONTROLLED TRIAL; REACTION TIME; SLEEP PARAMETERS; SLEEP PATTERN; SLEEP WAKING CYCLE; WAKEFULNESS; ANALYSIS OF VARIANCE; BODY TEMPERATURE; CIRCADIAN RHYTHM SLEEP DISORDER; COGNITION DISORDERS; COMPLICATION; DRUG EFFECTS; LEARNING DISORDERS; PAIN MEASUREMENT; PROCEDURES; SLEEP DEPRIVATION; TIME; YOUNG ADULT;

ADULT; ANALYSIS OF VARIANCE; BENZHYDRYL COMPOUNDS; BODY TEMPERATURE; COGNITION DISORDERS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; LEARNING DISORDERS; MALE; NEUROPROTECTIVE AGENTS; PAIN MEASUREMENT; POLYSOMNOGRAPHY; PSYCHOMOTOR PERFORMANCE; SLEEP DEPRIVATION; SLEEP DISORDERS, CIRCADIAN RHYTHM; TIME FACTORS; WAKEFULNESS; YOUNG ADULT;

EID: 77954762746     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/npp.2010.63     Document Type: Article

References (41)

1. Aeschbach D, Cutler AJ, Ronda JM (2008). A role for non-rapid eye movement sleep homeostasis in perceptual learning. J Neurosci 28: 2766-2772.
2. Åkerstedt T, Czeisler CA, Dinges DF, Horne JA (1994). Accidents and sleepiness: a consensus statement from the international conference on work hours, sleepiness and accidents, Stockholm, 8-10 September 1994. J Sleep Res 3: 195.
3. Barger LK, Cade BE, Ayas NT, Cronin JW, Rosner B, Speizer FE, et al, Harvard Work Hours, Health and Safety Group (2005). Extended work shifts and the risk of motor vehicle crashes among interns. N Engl J Med 352: 125-134.
4. Barger LK, Ayas NT, Cade BE, Cronin JW, Rosner B, Speizer FE et al (2006). Impact of extended-duration shifts on medical errors, adverse events, and attentional failures. PLoS Med 3: e487.
5. Bodenmann S, Xu S, Luhann UFO, Arand M, Berger W, Jung HH et al (2009). Pharmacogenetics of modafinil after sleep loss: catechol-o-methyltransferase genotype modulates waking functions but not recovery sleep. Clin Pharmacol Ther 85: 296-304.
6. Boivin DB, Czeisler CA, Dijk D-J, Duffy JF, Folkard S, Minors DS et al (1997). Complex interaction of the sleep-wake cycle and circadian phase modulates mood in healthy subjects. Arch Gen Psychiatry 54: 145-152.
7. Bourdon L, Jacobs I, Bateman WA, Vallerand AL (1994). Effect of modafinil on heat production and regulation of body temperatures in cold-exposed humans. Aviat Space Environ Med 65: 999-1003.
8. Brun J, Chamba G, Khalfallah Y, Girard P, Boissy I, Bastuji H et al (1998). Effect of modafinil on plasma melatonin, cortisol and growth hormone rhythms, rectal temperature and performance in healthy subjects during a 36 h sleep deprivation. J Sleep Res 7: 105-114.
9. Buguet A, Montmayeur A, Pigeau R, Naitoh P (1995). Modafinil, d-amphetamine and placebo during 64 hours of sustained mental work. II. Effects on two nights of recovery sleep. J Sleep Res 4: 229-241.
10. Caldwell JA, Caldwell L, Smythe NK, Hall KK (2000). A double blind, placebo-controlled investigation of the efficacy of modafinil for sustaining alertness and performance of aviators: a helicopter simulator study. Psychopharmacology 150: 272-282.
11. Czeisler CA, Duffy JF, Shanahan TL, Brown EN, Mitchell JF, Rimmer DW et al (1999). Stability, precision, and near-24-h period of the human circadian pacemaker. Science 284: 2177-2181.
12. Czeisler CA, Walsh JK, Roth T, Hughes RJ, Wright KP, Kingsbury L, et al, US Modafinil in Shift Work Sleep Disorder Study Group (2005). Modafinil for excessive sleepiness associated with shiftwork sleep disorder. N Engl J Med 353: 476-486.
13. Czeisler CA (2009). Medical and genetic differences in the adverse impact of sleep loss on performance: ethical considerations for the medical profession. Trans Am Clin Climatol Assoc 120: 249-285.
14. Dijk D-J, Duffy JF, Czeisler CA (1992). Circadian and sleep/wake dependent aspects of subjective alertness and cognitive performance. J Sleep Res 1: 112-117.
15. Dinges DF, Pack F, Williams K, Gillen KA, Powell JW, Ott GE et al (1997). Cumulative sleepiness, mood disturbance, and psycho- motor vigilance performance decrements during a week of sleep restricted to 4-5 h per night. Sleep 20: 267-277.
16. Dunwiddie TV, Masino SA (2001). The role and regulation of adenosine in the central nervous system. Annu Rev Neurosci 24: 31-55.
17. Eddy DR, Schiflett SG, Schlegel RE, Shehab RL (1998). Cognitive performance aboard the life and microgravity spacelab. Acta Astronaut 43: 193-210.
18. Engber TM, Koury EJ, Dennis SA, Miller MS, Contreras PC, Bhat RV (1998). Differential patterns of regional c-Fos induction in the rat brain by amphetamine and the novel wakefulness- promoting agent modafinil. Neurosc Lett 241: 95-98.
19. Fortson KN (2004). The diurnal pattern of on-the-job Injuries. Monthly Labor Review 127: 18-25.
20. Gallopin T, Luppi P-H, Rambert FA, Frydman A, Fort P (2004). Effect of the wake-promoting agent modafinil on sleep- promoting neurons from the ventrolateral preoptic nucleus: an in vitro pharmacologic study. Sleep 27: 19-25.
21. Hull JT, Wright Jr KP, Czeisler CA (2003). The influence of subjective alertness and motivation on human performance independent of circadian and homeostatic regulation. J Biol Rhythms 18: 329-338.
22. Johnson MP, Duffy JF, Dijk D-J, Ronda JM, Dyal CM, Czeisler CA (1992). Short-term memory, alertness, and performance: a reappraisal of their relationship to body temperature. J Sleep Res 1: 24-29.
23. Kopp C, Petit J-M, Magistretti P, Borbely AA, Tobler I (2002). Comparison of the effects of modafinil and sleep deprivation on sleep and cortical EEG spectra in mice. Neuropsychopharmacology 43: 110-118.
24. Landolt HP (2008). Sleep homeostasis: A role for adenosine in humans? Biochem Pharmacol 75: 2070-2079.
25. National Transportation Safety Board (1990). Marine accident report-grounding of the US tankship EXXON VALDEZ on Bligh Reef, Prince William Sound, near Valdez, Alaska, March 24. National Transportation Safety Board: Washington, DC. NTSB/ MAR-90/04. 1989.
26. Pigeau R, Naitoh P, Buguet A, McCann C, Baranski J, Taylor M et al (1995). Modafinil, d-amphetamine and placebo during 64 h of sustained mental work. I. Effects on mood, fatigue, cognitive performance, and body temperature. J Sleep Res 4: 212-228.
27. Rajaratnam SMW, Arendt J (2001). Health in a 24-h society. Lancet 358: 999-1005.
28. Rechtschaffen A, Kales A (1968). A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects. US Government Printing Office: Washington, DC.
29. Santhi N, Aeschbach D, Horowitz TS, Czeisler CA (2008). The impact of sleep timing and bright light exposure on attentional impairment during night work. J Biol Rhythms 24: 341-352.
30. Scammell TE, Matheson J (1998). Modafinil: a novel stimulant for the treatment of narcolepsy. Exp Opin Investig Drugs 7: 99-112.
31. Spiegel K, Leproult R, van Cauter E (1999). Impact of sleep debt on metabolic and endocrine function. Lancet 354: 1435-1439.
32. US Nuclear Regulatory Commission (1986). Report on the Accident at the Chernobyl Nuclear Power Station. US Government Printing Office: Washington, DC.
33. Viola AU, Archer SN, James LM, Groeger JA, Lo JCY, Skene DJ et al (2007). PER3 polymorphism predicts sleep structure and waking performance. Curr Biol 17: 613-618.
34. Walsh JK, Randazzo AC, Stone KL, Schweitzer PK (2004). Modafinil improves alertness, vigilance, and executive function during simulated night shifts. Sleep 27: 434-439.
35. Walsh JK, Randazzo AC, Stone K, Eisenstein R, Feren SD, Kajy S et al (2006). Tiagabine is associated with sustained attention during sleep restriction: evidence for the value of slow-wave sleep enhancement? Sleep 29: 433-443.
36. Wesensten NJ, Belenky G, Kautz MA, Thorne DR, Reichardt RM, Balkin TJ (2002). Maintaining alertness and performance during sleep deprivation: modafinil versus caffeine. Psychopharmacology 159: 238-247.
37. Wright Jr KP, Hughes RJ, Kronauer RE, Dijk D-J, Czeisler CA (2001). Intrinsic near-24-h pacemaker period determines limits of circadian entrainment to a weak synchronizer in humans. Proc Natl Acad Sci USA 98: 14027-14032.
38. Wright Jr KP, Hull JT, Czeisler CA (2002). Relationship between alertness, performance, and body temperature in humans. Am J Physiol Regul Integr Comp Physiol 283: R1370-R1377.
39. Wright Jr KP, Hull JT, Hughes RJ, Ronda JM, Czeisler CA (2006). Sleep and wakefulness out of phase with internal biological time impairs learning in humans. J Cogn Neurosci 18: 508-521.
40. Wyatt JK, Ritz-De Cecco A, Czeisler CA, Dijk D-J (1999). Circadian temperature and melatonin rhythms, sleep, and neurobehavioral function in humans living on a 20-h day. Am J Physiol 277: R1152-R1163.
41. Wyatt JK, Cajochen C, Ritz-De Cecco A, Czeisler CA, Dijk D-J (2004). Low-dose repeated caffeine administration for circadian- phase-dependent performance degradation during extended wakefulness. Sleep 27: 374-381.