Balamuthia mandrillaris: Role of galactose in encystment and identification of potential inhibitory targets

Experimental Parasitology

Volumn 126, Issue 1, 2010, Pages 22-27

  Siddiqui, Ruqaiyyah ^a   Jarroll, Edward L ^b   Khan, Naveed Ahmed ^c  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b CITY UNIVERSITY OF NEW YORK   (United States)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Balamuthia mandrillaris; Encystment; Galactose binding protein; Phosphatidylinositol 3 kinase

Indexed keywords

GALACTOSE; GALAPTIN; GLUCOSE; MANNOSE; N ACETYLGLUCOSAMINE; PHOSPHATIDYLINOSITOL 3 KINASE; RHO KINASE; TYROSINE; XYLOSE;

ARTICLE; BALAMUTHIA MANDRILLARIS; CARBOHYDRATE ANALYSIS; CELL FUNCTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYST (RESTING STAGE); CYTOSKELETON; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SPECIES DIFFERENTIATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMIDES; AMOEBOZOA; BRAIN; CALCIUM-BINDING PROTEINS; CELLS, CULTURED; CHROMONES; CYTOCHALASIN D; CYTOSKELETON; ENDOTHELIAL CELLS; ENZYME INHIBITORS; GALACTOSE; GENISTEIN; HUMANS; MONOSACCHARIDE TRANSPORT PROTEINS; MORPHOLINES; PERIPLASMIC BINDING PROTEINS; PROTEIN KINASE INHIBITORS; PROTEIN TYROSINE PHOSPHATASES; PROTEIN-TYROSINE KINASES; PYRIDINES; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION; VANADATES;

BALAMUTHIA MANDRILLARIS;

EID: 77954757423     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2009.09.013     Document Type: Article

References (17)

1. Coppi A., Eichinger D. Regulation of Entamoeba invadens encystation and gene expression with galactose and N-acetylglucosamine. Molecular and Biochemical Parasitology 1999, 102:67-77.
2. Cordingley J., Wills R., Villemez C. Osmolarity is an independent trigger of Acanthamoeba castellanii differentiation. Journal of Cellular Biochemistry 1996, 61:167-171.
3. Eichinger D. A role for a galactose lectin and its ligands during encystment of Entamoeba. Journal of Eukaryotic Microbiology 2001, 48:17-21.
4. Eichinger D. Encystation in parasitic protozoa. Current Opinion in Microbiology 2001, 4:421-426.
5. Makioka A., Kumagai M., Ohtomo H., Kobayashi S., Takeuchi T. Inhibition of encystation of Entamoeba invadens by wortmannin. Parasitology Research 2001, 87:371-375.
6. Martinez A.J., Visvesvara G.S. Balamuthia mandrillaris infection. Journal of Medical Microbiology 2001, 50:205-207.
7. Matin A., Jeong S.R., Faull J., Rivas A.O., Khan N.A. Evaluation of prokaryotic and eukaryotic cells as food source for Balamuthia mandrillaris. Archives of Microbiology 2006, 186(4):261-271.
8. Matin A., Stins M., Kim K.S., Khan N.A. Balamuthia mandrillaris exhibit metalloprotease activities. FEMS Immunology and Medical Microbiology 2006, 47:83-91.
9. Matin A., Siddiqui R., Jung S., Kim K.S., Stins M., Khan N.A. Balamuthia mandrillaris interactions with human brain microvascular endothelial cells in vitro. Journal of Medical Microbiology 2007, 56:1110-1115.
10. Petri W.A., Haque R., Mann B.J. The bittersweet interface of parasite and host: lectin-carbohydrate interactions during human invasion by the parasite Entamoeba histolytica. Annual Reviews of Microbiology 2002, 56:39-64.
11. Siddiqui R., Khan N.A., Jarroll E.L. The cyst wall carbohydrate composition of Balamuthia mandrillaris. Parasitology Research 2009, 104:1439-1443.
12. Siddiqui R., Matin A., Warhurst D., Stins M., Khan N.A. Effect of antimicrobial compounds on Balamuthia mandrillaris encystment and human brain microvascular endothelial cell cytopathogenicity. Antimicrobial Agents and Chemotherapy 2007, 51(12):4471-4473.
13. Siddiqui R., Ortega-Rivas A., Khan N.A. Balamuthia mandrillaris resistance to hostile conditions. Journal of Medical Microbiology 2008, 57:428-431.
14. Spinozzi F., Pagliacci M.C., Migliorati G., Moraca R., Grignani F., Riccardi C., Nicoletti I. The natural tyrosine kinase inhibitor genistein produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells. Leukemia Research 1994, 18:431-439.
15. Visvesvara G.S., Martinez A.J., Schuster F.L., Leitch G.L., Wallace S.V., Sawyer T.K., Anderson M. Leptomyxid Ameba, a new agent of amebic meningoencephalitis in humans and animals. Journal of Clinical Microbiology 1990, 28:2750-2756.
16. Visvesvara G.S., Schuster F.L., Martinez A.J. Balamuthia mandrillaris N.G.,N.Sp., agent of amoebic meningoencephalitis in humans and other animals. Journal of Eukaryotic Microbiology 1993, 40:504-514.
17. Yazdanyar A., Essmann M., Larsen B. Genistein effects on growth and cell cycle of Candida albicans. Journal of Biomedical Sciences 2001, 8:153-159.