Epigenetic regulation of vitamin D converting enzymes

Journal of Steroid Biochemistry and Molecular Biology

Volumn 121, Issue 1-2, 2010, Pages 80-83

  Wjst, Matthias ^a   Heimbeck, Irene ^a   Kutschke, David ^a   Pukelsheim, Katrin ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

Epidemiology; Epigenetics; Hydroxylases; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; BISULFITE; OXYGENASE; STEROID 24 HYDROXYLASE; UNCLASSIFIED DRUG; CALCIDIOL 1 MONOOXYGENASE; COLECALCIFEROL 24 HYDROXYLASE; CYP24A1 PROTEIN, HUMAN; PRIMER DNA; STEROID MONOOXYGENASE; VITAMIN D;

ARTICLE; CPG ISLAND; DNA EXTRACTION; EPIGENETICS; GENE CONTROL; GENOME; HUMAN; METHYLATION; NONHUMAN; PERIPHERAL LYMPHOCYTE; CHEMISTRY; CYTOLOGY; DNA METHYLATION; GENETIC EPIGENESIS; GENETICS; GERMANY; KINETICS; LYMPHOCYTE; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; SIBLING; TISSUE DISTRIBUTION;

25-HYDROXYVITAMIN D3 1-ALPHA-HYDROXYLASE; BASE SEQUENCE; CPG ISLANDS; DNA METHYLATION; DNA PRIMERS; EPIGENESIS, GENETIC; GERMANY; HUMANS; KINETICS; LYMPHOCYTES; MOLECULAR SEQUENCE DATA; SIBLINGS; STEROID HYDROXYLASES; TISSUE DISTRIBUTION; VITAMIN D; VITAMIN D3 24-HYDROXYLASE;

EID: 77954756915     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2010.03.056     Document Type: Article

References (18)

1. Johannes F., Colot V., Jansen R.C. Epigenome dynamics: a quantitative genetics perspective. Nat. Rev. Genet. 2008, 883-890.
2. Omdahl J.L., Morris H.A., May B.K. Hydroxylase enzymes of the vitamin D pathway: expression, function, and regulation. Annu. Rev. Nutr. 2002, 22:139-166.
3. Chung I., Karpf A.R., Muindi J.R., Conroy J.M., Nowak N.J., et al. Epigenetic silencing of CYP24 in tumor-derived endothelial cells contributes to selective growth inhibition by calcitriol. J. Biol. Chem. 2007, 282:8704-8714.
4. Khorchide M., Lechner D., Cross H.S. Epigenetic regulation of vitamin D hydroxylase expression and activity in normal and malignant human prostate cells. J. Steroid Biochem. Mol. Biol. 2005, 93:167-172.
5. Shi H., Yan P.S., Chen C.M., Rahmatpanah F., Lofton-Day C., et al. Expressed CpG island sequence tag microarray for dual screening of DNA hypermethylation and gene silencing in cancer cells. Cancer Res. 2002, 3214-3220.
6. Novakovic B., Sibson M., Ng H.K., Manuelpillai U., Rakyan V., et al. Placenta-specific methylation of the vitamin D 24-hydroxylase gene: implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface. J. Biol. Chem. 2009, 284:14838-14848.
7. Kim M.-S., Fujiki R., Kitagawa H., Kato S. 1[alpha],25(OH)2D3-induced DNA methylation suppresses the human CYP27B1 gene. Mol. Cell. Endocrinol. 2007, 265-266:168-173.
8. Vieth R. How to optimize vitamin D supplementation to prevent cancer, based on cellular adaptation and hydroxylase enzymology. Anticancer Res. 2009, 29:3675-3684.
9. Wjst M. The vitamin D slant on allergy. Pediatr. Allergy Immunol. 2006, 17:477-483.
10. Wjst M. Introduction of oral vitamin D supplementation and the rise of the allergy pandemic. Allergy Asthma Clin. Immunol. 2009, 5:8.
11. Wjst M., Altmuller J., Faus-Kessler T., Braig C., Bahnweg M., et al. Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway. Respir. Res. 2006, 7:60.
12. Raby B.A., Lazarus R., Silverman E.K., Lake S., Lange C., et al. Association of vitamin D receptor gene polymorphisms with childhood and adult asthma. Am. J. Respir. Crit. Care Med. 2004, 170:1057-1065.
13. Shi H., Guo J., Duff D., Rahmatpanah F., Chitima-Matsiga R., et al. Discovery of novel epigenetic markers in non-Hodgkin's lymphoma. Carcinogenesis 2007, 60-70.
14. De Bustos C., Ramos E., Young J.M., Tran R.K., Menzel U., et al. Tissue-specific variation in DNA methylation levels along human chromosome 1. Epigenet. Chromatin 2009, 2:7.
15. Brehm J.M., Celedon J.C., Soto-Quiros M.E., Avila L., Hunninghake G.M., et al. Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica. Am. J. Respir. Crit. Care Med. 2009, 179:765-771.
16. Barros S., Offenbacher S. Epigenetics: connecting environment and genotype to phenotype and disease. J. Dent. Res. 2009, 400-408.
17. Bousquet J., Jacot W., Yssel H., Vignola A.M., Humbert M. Epigenetic inheritance of fetal genes in allergic asthma. Allergy 2004, 138-147.
18. Miller R., Ho S. Environmental epigenetics and asthma: current concepts and call for studies. Am. J. Respir. Crit. Care Med. 2008, 567-573.