A sensitive and specific HPGPC-FD method for the study of pharmacokinetics and tissue distribution of Radix Ophiopogonis polysaccharide in rats

Biomedical Chromatography

Volumn 24, Issue 8, 2010, Pages 820-825

  Lin, Xiao ^a   Wang, Zhuojun ^a   Sun, Guilan ^a   Shen, Lan ^a   Xu, Desheng ^b   Feng, Yi ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Shuguang Hospital   (China)

Author keywords

Fluorescence detection; High performance gel permeation chromatography; Pharmacokinetics; Polysaccharide; Tissue distribution

Indexed keywords

FINITE DIFFERENCE METHOD; FLUORESCENCE; GEL PERMEATION CHROMATOGRAPHY; TISSUE;

ANALYTES; FLUORESCEIN ISOTHIOCYANATE; FLUORESCENCE DETECTION; FRUCTANS; HIGH PERFORMANCE GEL PERMEATION CHROMATOGRAPHY; PERFORMANCE; RAT TISSUE; SIMPLE++; TISSUE DISTRIBUTIONS; WEIGHT-AVERAGE MOLECULAR WEIGHT;

PHARMACOKINETICS;

FLUORESCEIN ISOTHIOCYANATE; FRUCTAN; ISOPRENALINE; OPHIOPOGON ROOT; PLANT EXTRACT; POLYSACCHARIDE;

ACUTE HEART INFARCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BRAIN; CALIBRATION; CHINESE MEDICINE; CORRELATION COEFFICIENT; DRUG HALF LIFE; FLOW RATE; FLUORESCENCE; GEL PERMEATION CHROMATOGRAPHY; HEART; HERBAL MEDICINE; KIDNEY; LIVER; LUNG; MALE; MEDICINAL PLANT; MOLECULAR WEIGHT; NONHUMAN; OPHIOPOGONIS; PLANT ROOT; PLASMA; QUALITY CONTROL; RAT; SPLEEN; STOMACH; TISSUE DISTRIBUTION; TISSUE HOMOGENATE; VALIDATION PROCESS; ANIMAL; CHEMISTRY; DEVICES; EVALUATION STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PROCEDURES; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FRUCTANS; MALE; OPHIOPOGON; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; SENSITIVITY AND SPECIFICITY; TISSUE DISTRIBUTION;

EID: 77954754871     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1369     Document Type: Article

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