Motor behavioral abnormalities and histopathological findings of wistar rats inoculated with HTLV-1-infected MT2 cells

Brazilian Journal of Medical and Biological Research

Volumn 43, Issue 7, 2010, Pages 657-662

  Camara C C ^a,b   Oria R B ^a,c   Felismino, T C ^a   da Silva, A P ^a   da Silva, M A M ^a   Alcantara J V A ^a   Costa, S B C ^a,c   Vicente, A C P ^d   Teixeira Santos, T J ^a,c   de Castro Costa, C M ^a,c  

^a Federal University of Ceará   (Brazil)

^b UNIVERSIDADE FEDERAL RURAL DO SEMI ÁRIDO   (Brazil)

^c Ministério de Ciência Tecnologia e Inovação Salvador   (Brazil)

^d INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Experimental myelopathy; HTLV 1 infected MT2 cells; Motor behaviors; Wistar rats

Indexed keywords

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR CHANGE; CELL LINE; CONTROLLED STUDY; HISTOPATHOLOGY; HUMAN T CELL LEUKEMIA VIRUS 1; HUMAN T CELL LEUKEMIA VIRUS INFECTION; LOCOMOTION; LYMPHOCYTIC INFILTRATION; MALE; MOTOR DYSFUNCTION; NONHUMAN; RAT; SPASTIC PARESIS; SPINAL CORD DISEASE; WISTAR RAT;

HUMAN T-LYMPHOTROPIC VIRUS 1; RATTUS; RATTUS NORVEGICUS;

EID: 77954729531     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2010007500050     Document Type: Article

References (21)

1. Saito M. Immunogenetics and the pathological mechanisms of human T-cell leukemia virus type 1-(HTLV-1-) associated myelopathy/tropical spastic paraparesis (HAM/TSP). Interdiscip Perspect Infect Dis 2010; 2010: 478461.
2. Costa CM, De Figueiredo EG, Santos TJ, Frota CH, Lobo CC, Santos FJ, et al. Experimental HTLV-I infection and associated myelopathy. Arq Neuropsiquiatr 1998; 56: 494-497.
3. Minagawa H, Mora CA, Asher DM, Stone GA, Liberski PP, Gibbs CJ Jr. Transmission of human T-cell leukemia virus type I from a patient with HTLV-I associated myelopathy/ tropical spastic paraparesis and an asymptomatic carrier to rabbits. Arch Virol 1991; 118: 235-245.
4. Ishiguro N, Abe M, Seto K, Sakurai H, Ikeda H, Wakisaka A, et al. A rat model of human T lymphocyte virus type I (HTLV-I) infection. 1. Humoral antibody response, provirus integration, and HTLV-I-associated myelopathy/tropical spastic paraparesis-like myelopathy in seronegative HTLV-I carrier rats. J Exp Med 1992; 176: 981-989.
5. Kushida S, Matsumura M, Tanaka H, Ami Y, Hori M, Kobayashi M, et al. HTLV-1-associated myelopathy/tropical spastic paraparesis-like rats by intravenous injection of HTLV-1-producing rabbit or human T-cell line into adult WKA rats. Jpn J Cancer Res 1993; 84: 831-833.
6. De Castro-Costa CM. A preliminary analysis of an experimental long-term study of motor behavior and clinical aspects of Wistar rats inoculated with blood from HTLV-1 positive TSP patients from Ceará (Northeastern Brazil). In: Zaninovic' V (Editor), HTLV - Truths and Questions. Cali: Feriva; 1996. p 89-95.
7. Suga T, Kameyama T, Kinoshita T, Shimotohno K, Matsumura M, Tanaka H, et al. Infection of rats with HTLV-1: a small-animal model for HTLV-1 carriers. Int J Cancer 1991; 49: 764-769.
8. Uchiyama T. Human T cell leukemia virus type I (HTLV-I) and human diseases. Annu Rev Immunol 1997; 15: 15-37.
9. Araujo AQ, Leite AC, Lima MA, Silva MT. HTLV-1 and neurological conditions: when to suspect and when to order a diagnostic test for HTLV-1 infection? Arq Neuropsiquiatr 2009; 67: 132-138.
10. De Castro Costa CM, Carton H, Goubau P, D'Almeida JA. Brazilian studies on tropical spastic paraparesis. A metaanalysis. Arq Neuropsiquiatr 1994; 52: 585-591.
11. Olindo S, Cabre P, Lezin A, Merle H, Saint-Vil M, Signate A, et al. Natural history of human T-lymphotropic virus 1-associated myelopathy: a 14-year follow-up study. Arch Neurol 2006; 63: 1560-1566.
12. Ohya O. [Chronological analyses of neuropathological and molecular biological changes in affected spinal cord of HTLV-I-infected rat (HAM rat disease)]. Hokkaido Igaku Zasshi 2000; 75: 117-134.
13. Miyatake Y, Ikeda H, Ishizu A, Baba T, Ichihashi T, Suzuki A, et al. Role of neuronal interferon-gamma in the development of myelopathy in rats infected with human T-cell leukemia virus type 1. Am J Pathol 2006; 169: 189-199.
14. Tomaru U, Ikeda H, Ohya O, Abe M, Kasai T, Yamasita I, et al. Human T lymphocyte virus type I-induced myeloneuropathy in rats: implication of local activation of the pX and tumor necrosis factor-alpha genes in pathogenesis. J Infect Dis 1996; 174: 318-323.
15. Jiang X, Ikeda H, Tomaru U, Morita K, Tanaka Y, Yoshiki T. A rat model for human T lymphocyte virus type I-associated myeloneuropathy. Down-regulation of bcl-2 expression and increase in sensitivity to TNF-alpha of the spinal oligodendrocytes. J Neuroimmunol 2000; 106: 105-113.
16. De Castro-Costa M, Gybels J, Kupers R, Van Hees J. Scratching behaviour in arthritic rats: a sign of chronic pain or itch? Pain 1987; 29: 123-131.
17. Kupers RC, Nuytten D, De Castro-Costa M, Gybels JM. A time course analysis of the changes in spontaneous and evoked behaviour in a rat model of neuropathic pain. Pain 1992; 50: 101-111.
18. De Castro-Costa CM, Araujo AQ, Barreto MM, Takayanagui OM, Sohler MP, da Silva EL, et al. Proposal for diagnostic criteria of tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM). AIDS Res Hum Retroviruses 2006; 22: 931-935.
19. Tomaru U, Ikeda H, Jiang X, Ohya O, Yoshiki T. Provirus expansion and deregulation of apoptosis-related genes in the spinal cord of a rat model for human T-lymphocyte virus type I-associated myeloneuropathy. J Neurovirol 2003; 9: 530-538.
20. Lairmore MD, Silverman L, Ratner L. Animal models for human T-lymphotropic virus type 1 (HTLV-1) infection and transformation. Oncogene 2005; 24: 6005-6015.
21. Zhao TM, Hague B, Caudell DL, Simpson RM, Kindt TJ. Quantification of HTLV-I proviral load in experimentally infected rabbits. Retrovirology 2005; 2: 34.