Leprosy and HIV coinfection: A clinical, pathological, immunological, and therapeutic study of a cohort from a brazilian referral center for infectious diseases

Journal of Infectious Diseases

Volumn 202, Issue 3, 2010, Pages 345-354

  Talhari, Carolina ^a,c   Távora Mira, Marcelo ^d   Massone, Cesare ^f   Braga, Andréa ^a   Chrusciak Talhari, Anette ^a   Santos, Mônica ^a,c   Orsi, Ana Tereza ^a   Matsuo, Christiane ^a   Rabelo, Renata ^a   Nogueira, Lisiane ^a   De Lima Ferreira, Luiz Carlos ^b   Ribeiro Rodrigues, Rodrigo ^e   Talhari, Sinésio ^a  

^a Departments of Dermatology   (Australia)

^b Departments of Pathology   (Brazil)

^c UNIVERSIDADE DO ESTADO DO AMAZONAS   (Brazil)

^d PONTIFICAL CATHOLIC UNIVERSITY OF PARANÁ   (Brazil)

^e Department of Pathology and Núcleo de Doenças Infecciosas ^*  (Brazil)

^f MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CLOFAZIMINE; DAPSONE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PROTEINASE INHIBITOR; RIFAMPICIN; STEROID; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ARTICLE; BRAZIL; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; COHORT ANALYSIS; FEMALE; FOLLOW UP; HISTOPATHOLOGY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOLOGICAL MONITORING; IMMUNOPHENOTYPING; LEPROMATOUS LEPROSY; MALE; MIXED INFECTION; MULTIBACILLARY LEPROSY; MYCOBACTERIUM LEPRAE; PAUCIBACILLARY LEPROSY; PRIORITY JOURNAL; SKIN BIOPSY; TUBERCULOID LEPROSY; COMORBIDITY; GRANULOMA; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HOSPITALIZATION; IMMUNOLOGY; LEPROSY; LONGITUDINAL STUDY; MIDDLE AGED; PATHOLOGY; PREVALENCE;

ADULT; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; BRAZIL; COHORT STUDIES; COMORBIDITY; GRANULOMA; HIV INFECTIONS; HUMANS; LEPROSY; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; PREVALENCE; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 77954723676     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/653839     Document Type: Article

References (50)

1. World Health Organization. Global leprosy situation, 2008 (additional information). Wkly Epidemiol Rec 2008; 83:459.
2. Joint United Nations Programme on HIV/AIDS (UNAIDS). AIDS epidemic update. UNAIDS Web site. http://www.unaids.org/en/ KnowledgeCentre/HIVData/ GlobalReport/2008/2008-Global-report .asp. Published December 2008. Accessed 3 June 2009.
3. Ministério da Saú de. Programa Nacional de Hanseníase 2009. Ministe ́rio da Saúde Web site. http://dtr2004.saude.gov.br/sinanweb/tabnet/ dh?sinannet/hanseniase/bases/ Hansbrnet.def. Accessed 3 June 2009.
4. Ministério da Saú de, Secretária de Vigilância em Saú de, Programa Nacional de DST-AIDS. Portal informativo sobre AIDS e outras doenccedil;as sexualmente transmissíveis: boletim epidemioló gico AIDS. Ministério da Saú de Web site. http://www.aids.gov.br/data/Pages/ LUMIS9A49113DPTBRIE.htm. Published June 2008. Accessed 3 June 2009.
5. Ustianowski AP, Lawn SD, Lockwood DNJ. Interactions between HIV infection and leprosy: a paradox. Lancet Infect Dis 2006; 6:350-360.
6. Sekar B, Jayasheela M, Chattopadhya D, et al. Prevalence of HIV infection and high-risk characteristics among leprosy patients of south India; a case-control study. Int J Lepr Other Mycobact Dis 1994; 62: 527-531.
7. Andrade VL, Moreira AT, Avelleira JC. Prevalence of HIV-1 in leprosy patients in Rio de Janeiro, Brazil. Acta Leprol 1997; 10:159-163.
8. Machado P, David Y, Pedroso C, Brites C, Barral A, Barral-Netto M. Leprosy and HIV infection in Bahia, Brazil. Int J Lepr Other Mycobact Dis 1998; 66:227-229.
9. Leonard G, Sangare A, Verdier M, et al. Prevalence of HIV infection among patients with leprosy in African countries and Yemen. J Acquir Immune Defic Syndr 1990; 3:1109-1113.
10. Meeran K. Prevalence of HIV infection among patients with leprosy and tuberculosis in rural Zambia. BMJ 1989; 298:364-365.
11. Pönnighaus JM, Mwanjasi LJ, Fine PE, et al. Is HIV infection a risk factor for leprosy? Int J Lepr Other Mycobact Dis 1991; 59:221-228.
12. Frommel D, Tekle-Haimanot R, Verdier M, Negesse Y, Bulto T, Denis F. HIV infection and leprosy: a four-year survey in Ethiopia. Lancet 1994; 344:165-166.
13. Borgdorff MW, van den Broek J, Chum HJ, et al. HIV-1 infection as a risk factor for leprosy; a case-control study in Tanzania. Int J Lepr Other Mycobact Dis 1993; 61:556-562.
14. Kawuma HJ, Bwire R, Adatu-Engwau F. Leprosy and infection with the human immunodeficiency virus in Uganda: a case-control study. Int J Lepr Other Mycobact Dis 1994; 62:521-526.
15. Lienhardt C, Kamate B, Jamet P, et al. Effect of HIV infection on leprosy: a three-year survey in Bamako, Mali. Int J Lepr Other Mycobact Dis 1996; 64:383-391.
16. de Almeida AM, Roselino AM, Foss NT. Leprosy and HIV infection. Int J Lepr Other Mycobact Dis 1994; 62:133-135.
17. Moran CA, Nelson AM, Tuur SM, Luengu M, Fonseca L, Meyers WM. Leprosy in five human immunodeficiency virus-infected patients.Mod Pathol 1995; 8:662-664.
18. Sampaio EP, Caneshi JR, Nery JA, et al. Cellular immune response to Mycobacterium leprae infection in human immunodeficiency virusinfected individuals. Infect Immun 1995; 63:1848-1854.
19. Pereira GA, Stefani MM, Araú jo Filho JA, Souza LC, Stefani GP, Martelli CM. Human immunodeficiency virus type 1 (HIV-1) and Mycobacterium leprae co-infection: HIV-1 subtypes and clinical, immunologic, and histopathologic profiles in a Brazilian cohort. Am J Trop Med Hyg 2004; 71:679-684.
20. Schettini AP, Ribas J, Rebello PF, Ribas CB, Schettini MC. Leprosy and AIDS in the Amazon basin. Int J Lepr Other Mycobact Dis 1996; 64: 171-173.
21. Lamfers EJ, Bastiaans AH, Mravunac M, Rampen FH. Leprosy in the acquired immunodeficiency syndrome. Ann Intern Med 1987; 107:111-112.
22. Kennedy C, Lien RA, Stolz E, van Joost T, Naafs B. Leprosy and human immunodeficiency virus infection: a closer look at the lesions. Int J Dermatol 1990; 29:139-140.
23. Talhari C, Machado PR, Ferreira LC, Talhari S. Shifting of the clinical spectrum of leprosy in an HIV-positive patient: a manifestation of immune reconstitution inflammatory syndrome? Lepr Rev 2007; 78:151-154.
24. Talhari C, Ferreira LC, Araú jo JR, Talhari AC, Talhari S. Immune reconstitution inflammatory syndrome or upgrading type 1 reaction? report of two AIDS patients presenting a shifting from borderline lepromatous leprosy to borderline tuberculoid leprosy. Lepr Rev 2008; 79:429-435.
25. Landay AL, Bettendorf D, Chan E, et al. Evidence of immune reconstitution in anti-retroviral drug-experienced patients with advanced HIV disease. AIDS Res Hum Retroviruses 2002; 18:95-102.
26. Shelburne SA 3rd, Hamill RJ. The immune reconstitution inflammatory syndrome. AIDS Rev 2003; 5:67-79.
27. Huiras E, Preda V, Maurer T, Whitfeld M. Cutaneous manifestations of immune reconstitution inflammatory syndrome. Curr Opin HIV AIDS 2008; 3:453-460.
28. Chrusciak-Talhari A, Ribeiro-Rodrigues R, Talhari C, et al. Tegumentary leishmaniasis as the cause of immune reconstitution inflammatory syndrome (IRIS) in a HIV/Leishmania guyanensis co-infected patient. Am J Trop Med Hyg 2009; 81:559-564.
29. Lawn SD, Wood C, Lockwood DN. Borderline tuberculoid leprosy: an immune reconstitution phenomenon in a human immunodeficiency virus-infected person. Clin Infect Dis 2003; 36:e5-e6.
30. Pignataro P, Rocha Ada S, Nery JA, et al. Leprosy and AIDS: two cases of increasing inflammatory reactions at the start of highly active antiretroviral therapy. Eur J Clin Microbiol Infect Dis 2004; 23:408-411.
31. Couppié P, Abel S, Voinchet H, et al. Immune reconstitution inflammatory syndrome associated with HIV and leprosy. Arch Dermatol 2004; 140:997-1000.
32. Visco-Comandini U, Longo B, Cuzzi T, Paglia MG, Antonucci G. Tuberculoid leprosy in a patient with AIDS: a manifestation of immune restoration syndrome. Scand J Infect Dis 2004; 36:881-883.
33. Trindade MA, Manini MI, Masetti JH, Leite MA, TakashashMD, Naafs B. Leprosy and HIV co-infection in five patients. Lepr Rev 2005; 76: 162-166.
34. Kharkar V, Bhor UH, Mahajan S, Khopkar U. Type I lepra reaction presenting as immune reconstitution inflammatory syndrome. Indian J Dermatol Venereol Leprol 2007; 73:253-256.
35. Batista MD, Porro AM, Maeda SM, et al. Leprosy reversal reaction as immune reconstitution inflammatory syndrome in patients with AIDS. Clin Infect Dis 2008; 46:e56-e60.
36. Martiniuk F, Rao SD, Rea TH, et al. Leprosy as immune reconstitution inflammatory syndrome in HIV-positive persons. Emerg Infect Dis 2007; 13:1438-1440.
37. Menezes VM, Sales AM, Illarramendi X, et al. Leprosy reaction as a manifestation of immune reconstitution inflammatory syndrome: a case series of a Brazilian cohort. AIDS 2009; 23:641-643.
38. Deps PD, Lockwood DN. Leprosy occurring as immune reconstitution syndrome. Trans R Soc Trop Med Hyg 2008; 102:966-968.
39. Talhari C, Matsuo C, Chrusciak-Talhari A, de-Lima-Ferreira LC, Mira M, Talhari S. Variations in leprosy manifestations among HIV-positive patients, Manaus, Brazil. Emerg Infect Dis 2009; 15:673-674.
40. Ministério da Saú de, Secretária Nacional de Vigilância em Saú de, Programa Nacional de DST-AIDS. Portal informativo sobre AIDS e outras doenccedil;as sexualmente transmissíveis: recomendaccedil;ões para terapia antiretroviral em adultos infectados pelo HIV. Ministério da Saúde Web site. http://www.aids.gov.br/ data/Pages/LUMISFB7D5720PTBRIE.htm. Accessed 3 June 2009.
41. Ministério da Saú de. Ministério da Saúde Web site. http://bvsms.saude.gov.br/bvs/publicacoes/guia-de-hanseniase.pdf. Accessed 3 June 2009.
42. Ridley DS, Jopling WH. A classification of leprosy for research purposes. Lepr Rev 1962; 33:119-128.
43. Ridley DS. Histological classification and the immunological spectrum of leprosy. Bull World Health Organ 1974; 51:451-465. 44. Van Brakel WH, Saunderson P, Shetty V, et al. International workshop on neuropathology in leprosy-consensus report. Lepr Rev 2007; 78: 416-433.
44. Van Brakel WH, Saunderson P, Shetty V, et al. International workshop on neuropathology in leprosy-consensus report. Lepr Rev 2007; 78:451-465.
45. Buhrer-Sekula S, Sarno EN, Oskam L, et al. Use of ML dipstick as a tool to classify leprosy patients. Int J Lepr Other Mycobact Dis 2000;68: 456-463.
46. Cerroni L, Smolle J, Soyer HP, et al. Immunophenotyping of cutaneous lymphoid infiltrates in frozen and paraffin-embedded tissue sections: a comparative study. J Am Acad Dermatol 1990; 22:405-413.
47. Ministério da Saú de, Sistema de Informaccedil;ão de Agravos de Notificaccedil;ão (SINAN). Casos de aids e taxa de incidência (por 100 mil hab) notificados ao SINAM, em indivíduos maiores de 13 anos, segundo munici ́pio de residencia e anos de diagnó stico, no período de 2005 a 2009 e total acumulado de 1986 a 2009 na cidade Manaus e Amazonas, Amazonas, 2009. Ministério da Saúde Web site. http://www.aids.gov .br/cgi/deftohtm.exe?tabnet/am.def. Accessed 3 June 2009.
48. Sarno EN, Illarramendi X, Nery JA, et al. HIV-M. leprae interaction: can HAART modify the course of leprosy? Public Health Rep 2008; 123:206-212.
49. Pardo CA, McArthur JC, Griffin JW. HIV neuropathy: insights in the pathology of HIV peripheral nerve disease. J Peripher Nerv Syst 2001;6: 21-27.
50. Languillon J, Carayon A. A summary of leprology. Acta Leprol 1988;6: 1-391.