Weight gain and insulin resistance in children treated with valproate: The influence of time

Journal of Child Neurology

Volumn 25, Issue 8, 2010, Pages 941-947

  Masuccio, Fabio ^a   Verrotti, Alberto ^a   Chiavaroli, Valentina ^a   De Giorgis, Tommaso ^a   Giannini, Cosimo ^a   Chiarelli, Francesco ^a   Mohn, Angelika ^a  

^a UNIVERSITY OF CHIETI   (Italy)

Author keywords

diabetes; insulin resistance; valproate; weight

Indexed keywords

GLUCOSE; GLUCOSE OXIDASE; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL; VALPROIC ACID;

ANTHROPOMETRIC PARAMETERS; ANTHROPOMETRY; AREA UNDER THE CURVE; ARTICLE; BIOCHEMISTRY; BLOOD SAMPLING; BODY FAT DISTRIBUTION; BODY SIZE; CHILD; CHOLESTEROL BLOOD LEVEL; CLINICAL ASSESSMENT; CONTROLLED STUDY; CORRELATION ANALYSIS; EPILEPSY; FEBRILE CONVULSION; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; LABORATORY TEST; LINEAR REGRESSION ANALYSIS; LONGITUDINAL STUDY; MALE; ORAL GLUCOSE TOLERANCE TEST; PRESCHOOL CHILD; PREVENTION; PRIORITY JOURNAL; SIDE EFFECT; WAIST HIP RATIO; WEIGHT GAIN;

ANTICONVULSANTS; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; HOMEOSTASIS; HUMANS; INSULIN RESISTANCE; LONGITUDINAL STUDIES; MALE; OBESITY; PROSPECTIVE STUDIES; VALPROIC ACID; WEIGHT GAIN;

EID: 77954716663     PISSN: 08830738     EISSN: 17088283     Source Type: Journal    
DOI: 10.1177/0883073809349461     Document Type: Article

References (26)

1. Greenwood RS Adverse effects of antiepileptic drugs. Epilepsia. 2000 ; 41 (suppl 2). S42 - S52.
2. Egger J., Brett EM Effects of sodium valproate in 100 children with special reference to weight. Br Med J (Clin Res Ed). 1981 ; 283 (6291). 577-581. (Pubitemid 11052923)
3. Novak GP, Maytal J., Alshansky A., Eviatar L., Sy-Kho R., Siddique Q. Risk of excessive weight gain in epileptic children treated with valproate. J Child Neurol. 1999 ; 14 (8). 490-495.
4. Espinosa PS, Salazar JC, Yu L., Mendiondo MS, Robertson WC, Baumann RJ Lack of valproic acid-associated weight gain in prepubertal children. Pediatr Neurol. 2008 ; 39 (3). 177-180.
5. Rauchenzauner M., Haberlandt E., Scholl-Burgi S., et al. Effect of valproic acid treatment on body composition, leptin and the soluble leptin receptor in epileptic children. Epilepsy Res. 2008 ; 80 (2-3). 142-149.
6. Pylvanen V., Pakarinen A., Knip M., Isojarvi J. Insulin-related metabolic changes during treatment with valproate in patients with epilepsy. Epilepsy Behav. 2006 ; 8 (3). 643-648.
7. Isojarvi JI, Laatikainen TJ, Knip M., Pakarinen AJ, Juntunen KT, Myllylǎ VV Obesity and endocrine disorders in women taking valproate for epilepsy. Ann Neurol. 1996 ; 39 (5). 579-584.
8. Aydin K., Serdaroglu A., Okuyaz C., Bideci A., Gucuyener K. Serum insulin, leptin and neuropeptide Y levels in epileptic children treated with valproate. J Child Neurol. 2005 ; 20 (10). 848-851.
9. Lagace DC, Mcleod RS, Nachtigal MW Valproic acid inhibits leptin secretion and reduces leptin messenger ribonucleic acid levels in adipocytes. Endocrinology. 2004 ; 145 (12). 5493-5503.
10. Verrotti A., la Torre R., Trotta D., Mohn A., Chiarelli F. Valproate-induced insulin resistance and obesity in children. Horm Res. 2009 ; 71 (3). 125-131.
11. Luef GJ, Lechleitner M., Bauer G., Trinka E., Hengster P. Valproic acid modulates islet cell insulin secretion: a possible mechanism of weight gain in epilepsy patients. Epilepsy Res. 2003 ; 55 (1-2). 53-58.
12. Verrotti A., Basciani F., Morresi S., de Martino M., Morgese G., Chiarelli F. Serum leptin changes in epileptic patients who gain weight after therapy with valproic acid. Neurology. 1999 ; 53 (1). 230-232.
13. Type 2 diabetes in children and adolescents. American Diabetes Association. Pediatrics. 2000 ; 105 (3 pt 1). 671-680.
14. Weiss R., Caprio S. The metabolic consequences of childhood obesity. Best Pract Res Clin Endocrinol Metab. 2005 ; 19 (3). 405-419.
15. Engel J. Jr. ILAE classification of epilepsy syndromes. Epilepsy Res. 2006 ; 70 (suppl 1). S5 - S10.
16. World Health Organization. Part 1: Diagnosis and Classification of Diabetes Mellitus. Definition, Diagnosis and Classification of Diabetes Mellitus and Its Complications. Geneva, Switzerland: WHO/NCD/NCS/99.2; 1999.
17. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985 ; 28 (7). 412-419.
18. CDC National Center for Health Statistics, Health E-Stat. NHANES Data on the Prevalence of Overweight Among Children and Adolescents. United States; 2003-2004.
19. Moreno LA, Rodr±guez G., Guillen J., Rabanaque MJ, León JF, Ariño A. Anthropometric measurements in both sides of the body in the assessment of nutritional status in prepubertal children. Eur J Clin Nutr. 2002 ; 56 (12). 1208-1215.
20. Caksen H., Deda G., Berberoglu M. Does long-term use of valproate cause weight gain in prepubertal epileptic children ? Int J Neurosci. 2002 ; 112 (10). 1183-1189.
21. Knowler WC, Barrett-Connor E., Fowler SE, et al., for the Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002 ; 346 (6). 393-403.
22. Demir E., Aysun S. Weight gain associated with valproate in childhood. Pediatr Neurol. 2000 ; 22 (5). 361-364.
23. Pylvanen V., Pakarinen A., Knip M., Isojarvi J. Characterization of insulin secretion in valproate treated patients with epilepsy. Epilepsia. 2006 ; 47 (9). 1460-1464.
24. Vorum H., Gram L., Honore B. Valproate and palmitate binding to serum albumin in valproate-treated patients. Relation to obesity. Epilepsy Res. 1993 ; 16 (1). 55-64.
25. Ferranini E., Barrett EJ, Bevilacqua S., De Fronzo RA Effects of free fatty acids on glucose production and utilization in man. J Clin Invest. 1983 ; 72: 1268-1277.
26. Grosso S., Mostardini R., Piccini B., Balestri P. Body mass index and serum lipid changes during treatment with valproic acid in children with epilepsy. Ann Pharmacother. 2009 ; 43 (1). 45-50.