Chondroitin-6-sulfate incorporation and mechanical stimulation increase MSC-collagen sponge construct stiffness

Journal of Orthopaedic Research

Volumn 28, Issue 8, 2010, Pages 1092-1099

  Kinneberg, Kirsten R C ^a   Nirmalanandhan, Victor S ^a,b   Juncosa Melvin, Natalia ^a,c   Powell, Heather M ^d,e   Boyce, Steven T ^d,f   Shearn, Jason T ^a   Butler, David L ^a  

^a University of Cincinnati   (United States)

^b UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^c Surgical Energetics Inc   (United States)

^d SHRINERS HOSPITALS FOR CHILDREN   (United States)

^e Ohio State University   (United States)

^f UNIVERSITY OF CINCINNATI   (United States)

Author keywords

Collagen GAG; Mechanical stimulation; Patellar tendon; Tissue engineering

Indexed keywords

CHONDROITIN 6 SULFATE; COLLAGEN SPONGE; COLLAGEN TYPE 1; COLLAGEN TYPE 3; DECORIN; FIBRONECTIN; MESSENGER RNA; TISSUE SCAFFOLD; CHONDROITIN SULFATE; COLLAGEN; PROTEOGLYCAN; SCLEROPROTEIN;

ANIMAL CELL; ARTICLE; CELL DENSITY; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; MECHANICAL STIMULATION; MESENCHYMAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; RABBIT; RIGIDITY; SCANNING ELECTRON MICROSCOPY; TISSUE ENGINEERING; ANIMAL; BIOMECHANICS; BIOSYNTHESIS; CHEMISTRY; METABOLISM; PHYSIOLOGY; TENSILE STRENGTH;

ANIMALS; BIOMECHANICS; CHONDROITIN SULFATES; COLLAGEN; COLLAGEN TYPE I; COLLAGEN TYPE III; EXTRACELLULAR MATRIX PROTEINS; FEMALE; FIBRONECTINS; MESENCHYMAL STEM CELLS; PROTEOGLYCANS; RABBITS; TENSILE STRENGTH; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 77954708557     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.21095     Document Type: Article

References (36)

1. Praemer A, Furner S, Rice D. 1999. Musculoskeletal conditions in the United States. Rosemont, IL: American Academy of Orthopaedic Surgeons
2. McGuire DA, Hendricks SD. 2007. Allografts in sports medicine. Oper Tech Sports Med 15:46-52.
3. Juncosa-Melvin N, Shearn JT, Boivin GP, et al. 2006. Effects of mechanical stimulation on the biomechanics and histology of stem cell-collagen sponge constructs for rabbit patellar tendon repair. Tissue Eng 12:2291-2300. (Pubitemid 44734987)
4. Baer GS, Harner CD. 2007. Clinical outcomes of allograft versus autograft in anterior cruciate ligament reconstruction. Clin Sports Med 26:661-681. (Pubitemid 47503512)
5. Woo SL, Vogrin TM, Abramowitch SD. 2000. Healing and repair of ligament injuries in the knee. J Am Acad Orthop Surg 8:364-372.
6. Qin T, Yang Z, Wu Z, et al. 2005. Adhesion strength of human tenocytes to extracellular matrix component-modified poly(DLlactide- co-glycolide) substrates. Biomaterials 26:6635-6642.
7. Sahoo S, Ouyang H, James C, et al. 2006. Characterization of a novel polymeric scaffold for potential application in tendon/ ligament tissue engineering. Tissue Eng 12:91-99.
8. Liu Y, Ramanath HS, Wang D. 2008. Tendon tissue engineering using scaffold enhancing strategies. Trends Biotechnol 26:201-209.
9. Cornwell KG, Lei P, Andreadis ST, et al. 2007. Crosslinking of discrete self-assembled collagen threads. J Biomed Mater Res A 80:362-371.
10. Guilak F, Butler DL, Mooney D, et al. 2003. Functional tissue engineering. New York: Springer-Verlag; 480 p.
11. Butler DL, Juncosa-Melvin N, Boivin GP, et al. 2008. Functional tissue engineering for tendon repair. J Orthop Res 26: 1-9.
12. Awad HA, Boivin GP, Dressler MR, et al. 2003. Repair of patellar tendon injuries using a cell-collagen composite. J Orthop Res 21:420-431.
13. Juncosa-Melvin N, Matlin KS, Holdcraft RW, et al. 2007. Mechanical stimulation increases collagen type I and collagen type III gene expression of stem cell-collagen sponge constructs for patellar tendon repair. Tissue Eng 13:1219-1226. (Pubitemid 46986722)
14. Shearn JT, Juncosa-Melvin N, Boivin GP, et al. 2007. Mechanical stimulation of tendon tissue engineered constructs. J Biomech Eng 129:848-854.
15. Nirmalanandhan VS, Dressler MR, Shearn JT, et al. 2007. Mechanical stimulation of tissue engineered tendon constructs: effect of scaffold materials. J Biomech Eng 129:919-923.
16. Malaviya P, Butler DL, Korvick DL, et al. 1998. In vivo tendon forces correlate with activity level and remain bounded. J Biomech 31:1043-1049.
17. Juncosa N, West JR, Galloway MT, et al. 2003. In vivo forces used to develop design parameters for tissue engineered implants for rabbit patellar tendon repair. J Biomech 36:483-488.
18. West JR, Juncosa N, Galloway MT, et al. 2004. Characterization of in vivo Achilles tendon forces in rabbits during treadmill locomotion at varying speeds and inclinations. J Biomech 37:1647-1653. (Pubitemid 39237577)
19. Korvick DL, Cummings JF, Grood ES, et al. 1996. The use of an implantable force transducer to measure patellar tendon forces in goats. J Biomech 29:557-561.
20. Yannas IV, Burke JF. 1980. Design of an artificial skin I. J Biomed Mater Res 14:65-81.
21. Yannas IV, Burke JF, Gordon PL. 1980. Design of an artificial skin II. J Biomed Mater Res 14:107-131.
22. Scott JE, Orford CR, Hughes EW. 1981. Proteoglycan-collagen arrangements in developing rat tail tendon. Biochem J 195: 573-581.
23. Redaelli A, Vesentini S, Soncini M, et al. 2003. Possible role of decorin glycosaminoglycans in fibril to fibril force transfer in relative mature tendons. J Biomech 36:1555-1569.
24. Yoon JH, Halper J. 2005. Tendon proteoglycans. J Musculoskelet Neuronal Interact 5:22-34.
25. Zhang G, Ezura Y, Chervoneva I, et al. 2006. Decorin regulates assembly of collagen fibrils and acquisition of biomechanical properties during tendon development. J Cell Biochem 98:1436-1449. (Pubitemid 44141849)
26. Reed CC, Iozzo RV. 2002. The role of decorin in collagen fibrillogenesis and skin homeostasis. Glycoconj J 19:249-255.
27. Boyce ST, Christianson DJ, Hansbrough JF. 1988. Structure of a collagen-GAG dermal skin substitute optimized for cultured human epidermal keratinocytes. J Biomed Mater Res 22:939-957.
28. Nirmalanandhan VS, Rao M, Shearn JT, et al. 2008. Effect of scaffold material, construct length and mechanical stimulation on the in vitro stiffness of the engineered tendon construct. J Biomech 41:822-828.
29. Guehring T, Omlor GW, Lorenz H, et al. 2005. Stimulation of gene expression and loss of anular architecture caused by experimental disc degeneration. Spine 30:2510-2515. (Pubitemid 41669086)
30. Boykiw R, Sciore P, Reno C, et al. 1998. Altered levels of extracellular matrix molecule mRNA in healing rabbit ligaments. Matrix Biology 17:371-378. (Pubitemid 28486299)
31. Banes AJ, Tsuzaki M, Yamamoto J, et al. 1995. Mechanoreception at the cellular level. Biochem Cell Biol 73:349-365.
32. Grossman Z, Paul WE. 1992. Adaptive cellular interactions in the immune system. Proc Natl Acad Sci USA 89:10365-10369.
33. Frank C, Schachar N, Dittrich D. 1983. Natural history of healing in the repaired medial collateral ligament. J Orthop Res 1:179-188. (Pubitemid 14130060)
34. Yamada KM. 1989. Fibronectins. Curr Opin Cell Biol 1:956-963.
35. Banes AJ, Link GW, Bevin AG, et al. 1988. Tendon synovial cells secrete fibronectin in vivo and in vitro. J Orthop Res 6:73-82.
36. Cook RD. 1999. Advanced mechanics of materials. Upper Saddle River, NJ: Prentice Hall. 481 p.