It,s a knockout: CCN3 suppresses neointimal thickening

Journal of Cell Communication and Signaling

Volumn 4, Issue 2, 2010, Pages 109-110

  Leask, Andrew ^a  

^a WESTERN UNIVERSITY   (Canada)

Author keywords

CCN3; Hyperplasia; Injury; Nov; Vasculature

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; CYSTEINE RICH PROTEIN 61; NEPHROBLASTOMA OVEREXPRESSED PROTEIN;

ANGIOGENESIS; AORTA; ARTICLE; CELL PROLIFERATION; HEART DISEASE; INTIMA; KNOCKOUT MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

MUS;

EID: 77954689177     PISSN: 18739601     EISSN: 1873961X     Source Type: Journal    
DOI: 10.1007/s12079-010-0086-y     Document Type: Article

References (12)

1. Bleau AM, Planque N, Perbal B (2005) CCN proteins and cancer: two to tango. Front Biosci 10:998-1009
2. Heath E, Tahri D, Andermarcher E, Schofield P, Fleming S, Boulter CA (2008) Abnormal skeletal and cardiac development, cardiomyopathy, muscle atrophy and cataracts in mice with a targeted disruption of the Nov (Ccn3) gene. BMC Dev Biol 8:18
3. Ivkovic S, Yoon BS, Popoff SN, Safadi FF, Libuda DE, Stephenson RC, Daluiski A, Lyons KM (2003) Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development 130:2779-2791
4. Kawaki H, Kubota S, Suzuki A, Lazar N, Yamada T, Matsumura T, Ohgawara T, Maeda T, Perbal B, Lyons KM, Takigawa M (2008) Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family proteins in cartilage. J Bone Miner Res 23:1751-1764
5. Leask A (2007) CCN3: a novel function in vivo. J Cell Commun Signal 1:227-228
6. Leask A (2009) Yin and Yang: CCN3 inhibits the pro-fibrotic effects of CCN2. J Cell Commun Signal 3:161-162
7. Leask A, Abraham DJ (2006) All in the CCN family. J Cell Science 119:4803-4810
8. Mo FE, Muntean AG, Chen CC, Stolz DB, Watkins SC, Lau LF (2002) CYR61 (CCN1) is essential for placental development and vascular integrity. Mol Cell Biol 22:8709-8720
9. Perbal B (2007) CCN3-mutant mice are distinct from CCN3-null mice. J Cell Commun Signal 1:229-230
10. Perbal B (2008) CCN3: doctor Jekyll and mister Hyde. J Cell Commun Signal 2:3-7
11. Riser BL, Najmabadi F, Perbal B, Peterson DR, Rambow JA, Riser ML, Sukowski E, Yeger H, Riser SC (2009) CCN3 (NOV) is a negative regulator of CCN2 (CTGF) and a novel endogenous inhibitor of the fibrotic pathway in an in vitro model of renal disease. Am J Pathol 174:1725-1734
12. Shimoyama S, Hiraoka S, Takemoto M, Koshizaka M, Tokuyama H, Tokuyama T, Watanabe A, Fujimoto M, Kawamura H, Sato S, Tsurutani Y, Saito Y, Perbal B, Koseki H, Yokote K (2010) CCN3 inhibits neointimal hyperplasia through modulation of smooth muscle cell growth and migration, in press