MMR gene expression pattern in sporadic colorectal cancer

Journal of Gastrointestinal and Liver Diseases

Volumn 19, Issue 2, 2010, Pages 155-159

  Ioana, Mihai ^a   Angelescu, Cristina ^a   Burada, Florin ^a   Mixich, Francisc ^a   Riza, Anca ^a   Dumitrescu, Theodor ^b   Alexandru, Dragos ^c   Ciurea, Tudorel ^a   Cruce, Mihai ^a   Saftoiu, Adrian ^a  

^a IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^b Emergency Hospital   (Romania)

^c UNIVERSITY OF MEDICINE AND PHARMACY OF CRAIOVA   (Romania)

Author keywords

Gene expression; MMR genes; qRT PCR; Sporadic colorectal cancer

Indexed keywords

COMPLEMENTARY DNA; MESSENGER RNA; MISMATCH REPAIR PROTEIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COLON ADENOCARCINOMA; COLON POLYP; COLORECTAL CANCER; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION; GENE MUTATION; GENETIC MARKER; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; MISMATCH REPAIR; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; CLUSTER ANALYSIS; COLORECTAL NEOPLASMS; DNA MISMATCH REPAIR; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTESTINAL POLYPS; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; ROMANIA;

EID: 77954688340     PISSN: 18418724     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Boyle P, Ferlay J. Cancer incidence and mortality in Europe, 2004. Ann Oncol 2005; 16: 481-488.
2. Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990; 61: 759-767.
3. de la Chapelle A. Genetic predisposition to colorectal cancer. Nat Rev Cancer 2004; 4: 769-780.
4. Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996; 87: 159-170.
5. Lichtenstein P, Holm NV, Verkasalo PK, et al. Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med 2000; 343: 78-85.
6. Ionov Y, Peinado MA, Malkhosyan S, Shibata D, Perucho M. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 1993; 363: 558-561.
7. Niessen RC, Berends MJ, Wu Y, et al. Identification of mismatch repair gene mutations in young patients with colorectal cancer and in patients with multiple tumors associated with hereditary non-polyposis colorectal cancer. Gut 2006; 55: 1781-1788.
8. Kane MF, Loda M, Gaida GM, et al. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res 1997; 57: 808-811.
9. Koopman M, Kortman GA, Mekenkamp L, et al. Deficient mismatch repair system in patients with sporadic advanced colorectal cancer. Br J Cancer 2009; 100: 266-273.
10. Kunkel TA, Erie DA. DNA mismatch repair. Annu Rev Biochem 2005; 74: 681-710.
11. Schofield MJ, Hsieh P. DNA mismatch repair: molecular mechanisms and biological function. Annu Rev Microbiol 2003; 57: 579-608.
12. Aaltonen LA, Peltomaki P, Leach FS, et al. Clues to the pathogenesis of familial colorectal cancer. Science 1993; 260: 812-816.
13. Herman JG, Umar A, Polyak K, et al. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A 1998; 95: 6870-6875.
14. Thibodeau SN, Bren G, Schaid D. Microsatellite instability in cancer of the proximal colon. Science 1993; 260: 816-819.
15. Parsons R, Li GM, Longley MJ, et al. Hypermutability and mismatch repair deficiency in RER+ tumor cells. Cell 1993; 75: 1227-1236.
16. Habano W, Sugai T, Nakamura S. Mismatch repair deficiency leads to a unique mode of colorectal tumorigenesis characterized by intratumoral heterogeneity. Oncogene 1998; 16: 1259-1265.
17. Deng M, Li F, Ballif BA, et al. Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17. J Biol Chem 2009; 284: 7875-7888.
18. Jiricny J, Marra G. DNA repair defects in colon cancer. Curr Opin Genet Dev 2003; 13: 61-69.
19. Jiricny J. The multifaceted mismatch-repair system. Nat Rev Mol Cell Biol 2006; 7: 335-346.
20. Genschel J, Bazemore LR, Modrich P. Human exonuclease I is required for 5' and 3' mismatch repair. J Biol Chem 2002; 277: 13302-13311.
21. Liang SB, Furihata M, Takeuchi T, Sonobe H, Ohtsuki Y. Reduced human mismatch repair protein expression in the development of precancerous skin lesions to squamous cell carcinoma. Virchows Arch 2001; 439:622-627.
22. Bonte H, Flejou JF. Patterns of expression of MMR proteins in serrated adenomas and other polyps of the colorectum. Gut 2003; 52: 611.