Lymphovascular invasion is an independent predictor of oncological outcomes in patients with lymph node-negative urothelial bladder cancer treated by radical cystectomy: A multicentre validation trial

BJU International

Volumn 106, Issue 4, 2010, Pages 493-499

  Bolenz, Christian ^a   Herrmann, Edwin ^b   Bastian, Patrick J ^c   Michel, Maurice S ^a   Wülfing, Christian ^b   Tiemann, Arne ^b   Buchner, Alexander ^c   Stief, Christian G ^c   Fritsche, Hans Martin ^d   Burger, Maximilian ^d   Wieland, Wolf F ^d   Höfner, Thomas ^e   Haferkamp, Axel ^e   Hohenfellner, Markus ^e   Müller, Stefan C ^f   Ströbel, Philipp ^a   Trojan, Lutz ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

^d UNIVERSITY OF REGENSBURG   (Germany)

^e UNIVERSITY OF HEIDELBERG   (Germany)

^f UNIVERSITY OF BONN   (Germany)

Author keywords

bladder cancer; lymphatic metastasis; lymphovascular invasion; prognosis; survival; urothelial carcinoma

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; BLADDER CANCER; BLADDER EPITHELIUM; CANCER INVASION; CANCER RECURRENCE; CANCER STAGING; CANCER SURVIVAL; CHILD; CLINICAL TRIAL; CYSTECTOMY; FEMALE; HUMAN; INFANT; LYMPH NODE METASTASIS; LYMPHOVASCULAR INVASION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NEWBORN; PRESCHOOL CHILD; PRIORITY JOURNAL; PROGNOSIS; SCHOOL CHILD; TREATMENT OUTCOME; TUMOR CELL; UROTHELIAL BLADDER CANCER; VALIDATION STUDY; EPIDEMIOLOGY; LYMPH NODE; MIDDLE AGED; MORTALITY; PATHOLOGY; PROCEDURES; TUMOR INVASION; TUMOR RECURRENCE; URINARY BLADDER NEOPLASMS; UROTHELIUM; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; CYSTECTOMY; EPIDEMIOLOGIC METHODS; FEMALE; HUMANS; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM RECURRENCE, LOCAL; PROGNOSIS; TREATMENT OUTCOME; URINARY BLADDER NEOPLASMS; UROTHELIUM;

EID: 77954686506     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2009.09166.x     Document Type: Article

References (48)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer J Clin 2009 59 : 225 249
2. Shariat SF, Karakiewicz PI, Palapattu GS et al. Outcomes of radical cystectomy for transitional cell carcinoma of the bladder: a contemporary series from the Bladder Cancer Research Consortium. J Urol 2006 176 : 2414 2422
3. Stein JP, Lieskovsky G, Cote R et al. Radical cystectomy in the treatment of invasive bladder cancer: long-term Results in 1,054 patients. J Clin Oncol 2001 19 : 666 675
4. Kim WJ, Bae SC. Molecular biomarkers in urothelial bladder cancer. Cancer Sci 2008 99 : 646 652
5. Lotan Y, Gupta A, Shariat SF et al. Lymphovascular invasion is independently associated with overall survival, cause-specific survival, and local and distant recurrence in patients with negative lymph nodes at radical cystectomy. J Clin Oncol 2005 23 : 6533 6539
6. Margulis V, Lotan Y, Montorsi F, Shariat SF. Predicting survival after radical cystectomy for bladder cancer. BJU Int 2008 102 : 15 22
7. Bassi P, Ferrante GD, Piazza N et al. Prognostic factors of outcome after radical cystectomy for bladder cancer: a retrospective study of a homogeneous patient cohort. J Urol 1999 161 : 1494 1497
8. Harada K, Sakai I, Hara I, Eto H, Miyake H. Prognostic significance of vascular invasion in patients with bladder cancer who underwent radical cystectomy. Int J Urol 2005 12 : 250 255
9. Quek ML, Stein JP, Nichols PW et al. Prognostic significance of lymphovascular invasion of bladder cancer treated with radical cystectomy. J Urol 2005 174 : 103 106
10. Canter D, Guzzo T, Resnick M et al. The presence of lymphovascular invasion in radical cystectomy specimens from patients with urothelial carcinoma portends a poor clinical prognosis. BJU Int 2008 102 : 952 957
11. Horikawa Y, Kumazawa T, Narita S et al. Lymphatic invasion is a prognostic factor for bladder cancer treated with radical cystectomy. Int J Clin Oncol 2007 12 : 131 136
12. Reuter VE. Lymphovascular invasion as an independent predictor of recurrence and survival in node-negative bladder cancer remains to be proven. J Clin Oncol 2005 23 : 6450 6451
13. Hara S, Miyake H, Fujisawa M et al. Prognostic variables in patients who have undergone radical cystectomy for transitional cell carcinoma of the bladder. Jpn J Clin Oncol 2001 31 : 399 402
14. Leissner J, Koeppen C, Wolf HK. Prognostic significance of vascular and perineural invasion in urothelial bladder cancer treated with radical cystectomy. J Urol 2003 169 : 955 960
15. Karpanen T, Alitalo K. Molecular biology and pathology of lymphangiogenesis. Annu Rev Pathol 2008 3 : 367 397
16. Padera TP, Kadambi A, di Tomaso E et al. Lymphatic metastasis in the absence of functional intratumor lymphatics. Science 2002 296 : 1883 1886
17. Lapham RL, Grignon D, Ro JY. Pathologic prognostic parameters in bladder urothelial biopsy, transurethral resection, and cystectomy specimens. Semin Diagn Pathol 1997 14 : 109 122
18. Freiha F, Reese J, Torti FM. A randomized trial of radical cystectomy versus radical cystectomy plus cisplatin, vinblastine and methotrexate chemotherapy for muscle invasive bladder cancer. J Urol 1996 155 : 495 499
19. Lehmann J, Franzaring L, Thuroff J, Wellek S, Stockle M. Complete long-term survival data from a trial of adjuvant chemotherapy vs control after radical cystectomy for locally advanced bladder cancer. BJU Int 2006 97 : 42 7
20. Skinner DG, Daniels JR, Russell CA et al. The role of adjuvant chemotherapy following cystectomy for invasive bladder cancer: a prospective comparative trial. J Urol 1991 145 : 459 464
21. Stockle M, Meyenburg W, Wellek S et al. Advanced bladder cancer (stages pT3b, pT4a, pN1 and pN2): improved survival after radical cystectomy and 3 adjuvant cycles of chemotherapy. Results of a controlled prospective study. J Urol 1992 148 : 302 306
22. Collaboration ABCAM-a. Adjuvant chemotherapy in invasive bladder cancer: a systematic review and meta-analysis of individual patient data Advanced Bladder Cancer (ABC) Meta-analysis Collaboration. Eur Urol 2005 48 : 189 199
23. Studer UE, Bacchi M, Biedermann C et al. Adjuvant cisplatin chemotherapy following cystectomy for bladder cancer: Results of a prospective randomized trial. J Urol 1994 152 : 81 4
24. Grossman HB, Natale RB, Tangen CM et al. Neoadjuvant chemotherapy plus cystectomy compared with cystectomy alone for locally advanced bladder cancer. N Engl J Med 2003 349 : 859 866
25. Streeper NM, Simons CM, Konety BR et al. The significance of lymphovascular invasion in transurethral resection of bladder tumour and cystectomy specimens on the survival of patients with urothelial bladder cancer. BJU Int 2009 103 : 475 479
26. Kunju LP, You L, Zhang Y, Daignault S, Montie JE, Lee CT. Lymphovascular invasion of urothelial cancer in matched transurethral bladder tumor resection and radical cystectomy specimens. J Urol 2008 180 : 1928 1932
27. Millikan R, Dinney C, Swanson D et al. Integrated therapy for locally advanced bladder cancer: final report of a randomized trial of cystectomy plus adjuvant M-VAC versus cystectomy with both preoperative and postoperative M-VAC. J Clin Oncol 2001 19 : 4005 4013
28. Shariat SF, Bolenz C, Godoy G et al. Predictive value of combined immunohistochemical markers in patients with pT1 urothelial carcinoma at radical cystectomy. J Urol 2009 182 : 78 84
29. Shariat SF, Karakiewicz PI, Ashfaq R et al. Multiple biomarkers improve prediction of bladder cancer recurrence and mortality in patients undergoing cystectomy. Cancer 2008 112 : 315 325
30. Kattan MW. Judging new markers by their ability to improve predictive accuracy. J Natl Cancer Inst 2003 95 : 634 635
31. Shariat SF, Karakiewicz PI, Ashfaq R et al. Multiple biomarkers improve prediction of bladder cancer recurrence and mortality in patients undergoing cystectomy. Cancer 2008 112 : 315 325
32. Vickers AJ, Jang K, Sargent D, Lilja H, Kattan MW. Systematic review of statistical methods used in molecular marker studies in cancer. Cancer 2008 112 : 1862 1868
33. Shariat SF, Margulis V, Lotan Y, Montorsi F, Karakiewicz PI. Nomograms for bladder cancer. Eur Urol 2008 54 : 41 53
34. Vauthey JN, Lauwers GY, Esnaola NF et al. Simplified staging for hepatocellular carcinoma. J Clin Oncol 2002 20 : 1527 1536
35. Albers P, Siener R, Kliesch S et al. Risk factors for relapse in clinical stage I nonseminomatous testicular germ cell tumors: Results of the German Testicular Cancer Study Group Trial. J Clin Oncol 2003 21 : 1505 1512
36. Krege S, Beyer J, Souchon R et al. European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus group (EGCCCG): part I. Eur Urol 2008 53 : 478 496
37. Algaba F. Lymphovascular invasion as a prognostic tool for advanced bladder cancer. Curr Opin Urol 2006 16 : 367 371
38. Sesterhenn IA, Weiss RB, Mostofi FK et al. Prognosis and other clinical correlates of pathologic review in stage I and II testicular carcinoma: a report from the Testicular Cancer Intergroup Study. J Clin Oncol 1992 10 : 69 78
39. Cheng L, Jones TD, Lin H et al. Lymphovascular invasion is an independent prognostic factor in prostatic adenocarcinoma. J Urol 2005 174 : 2181 2185
40. Lapham RL, Grignon D, Ro JY. Pathologic prognostic parameters in bladder urothelial biopsy, transurethral resection, and cystectomy specimens. Semin Diagn Pathol 1997 14 : 109 122
41. Larsen MP, Steinberg GD, Brendler CB, Epstein JI. Use of Ulex europaeus agglutinin I (UEAI) to distinguish vascular and 'pseudovascular' invasion in transitional cell carcinoma of bladder with lamina propria invasion. Mod Pathol 1990 3 : 83 8
42. Miyata Y, Kanda S, Ohba K et al. Tumor lymphangiogenesis in transitional cell carcinoma of the upper urinary tract: association with clinicopathological features and prognosis. J Urol 2006 176 : 348 353
43. Straume O, Jackson DG, Akslen LA. Independent prognostic impact of lymphatic vessel density and presence of low-grade lymphangiogenesis in cutaneous melanoma. Clin Cancer Res 2003 9 : 250 256
44. Clemente CG, Boracchi P, Andreola S, Del Vecchio M, Veronesi P, Rilke FO. Peritumoral lymphatic invasion in patients with node-negative mammary duct carcinoma. Cancer 1992 69 : 1396 1403
45. Davis BW, Gelber R, Goldhirsch A et al. Prognostic significance of peritumoral vessel invasion in clinical trials of adjuvant therapy for breast cancer with axillary lymph node metastasis. Hum Pathol 1985 16 : 1212 1218
46. Roma AA, Magi-Galluzzi C, Kral MA, Jin TT, Klein EA, Zhou M. Peritumoral lymphatic invasion is associated with regional lymph node metastases in prostate adenocarcinoma. Mod Pathol 2006 19 : 392 398
47. Leissner J, Koeppen C, Wolf HK. Prognostic significance of vascular and perineural invasion in urothelial bladder cancer treated with radical cystectomy. J Urol 2003 169 : 955 960
48. Hong SK, Kwak C, Jeon HG, Lee E, Lee SE. Do vascular, lymphatic, and perineural invasion have prognostic implications for bladder cancer after radical cystectomy? Urology 2005 65 : 697 702