Urinary collagen IV and πGST: Potential biomarkers for detecting localized kidney injury in diabetes - A pilot study

American Journal of Nephrology

Volumn 32, Issue 3, 2010, Pages 219-225

  Cawood, T J ^a   Bashir, M ^b   Brady, J ^b   Murray, B ^b   Murray, P T ^c   O'Shea, D ^b  

^a CHRISTCHURCH HOSPITAL   (New Zealand)

^b ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Glutathione S transferase; Glutathione S transferase; Collagen IV; Diabetes, urinary biomarkers; Localized kidney injury in diabetes; Urinary biomarkers

Indexed keywords

ALBUMIN; BIOLOGICAL MARKER; COLLAGEN TYPE 4; CREATININE; GLUTATHIONE TRANSFERASE ALPHA; GLUTATHIONE TRANSFERASE P1;

ADULT; AGED; ALBUMINURIA; ARTICLE; CONTROLLED STUDY; CREATININE URINE LEVEL; DIABETES MELLITUS; DIABETIC NEPHROPATHY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; KIDNEY FIBROSIS; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE DAMAGE; MAJOR CLINICAL STUDY; MALE; MICROALBUMINURIA; PILOT STUDY; PRIORITY JOURNAL; PROTEIN DETERMINATION;

ADULT; BIOLOGICAL MARKERS; COLLAGEN TYPE IV; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; FEMALE; GLUTATHIONE S-TRANSFERASE PI; GLUTATHIONE TRANSFERASE; HUMANS; ISOENZYMES; MALE; MIDDLE AGED; PILOT PROJECTS;

EID: 77954670803     PISSN: 02508095     EISSN: None     Source Type: Journal    
DOI: 10.1159/000317531     Document Type: Article

References (25)

1. Excerpts from the US Renal Data Systems 2002 Annual Report: Atlas of end-stage renal disease in the United States. Am J Kidney Dis 2003; 41:v-ix, S7-S254.
2. Gross JL, de Azevedo MJ, Silveiro SP, Canani LH, Caramori ML, Zelmanovitz T: Diabetic nephropathy: diagnosis, prevention, and treatment. Diabetes Care 2005; 28: 164-176.
3. Bennett PH, Haffner S, Kasiske BL, Keane WF, Mogensen CE, Parving HH, Steffes MW, Striker GE: Screening and management of microalbuminuria in patients with diabetes mellitus: recommendations to the Scientific Advisory Board of the National Kidney Foundation from an ad hoc committee of the Council on Diabetes Mellitus of the National Kidney Foundation. Am J Kidney Dis 1995; 25: 107-112.
4. Mogensen CE, Vestbo E, Poulsen PL, Christiansen C, Damsgaard EM, Eiskjær H, Froland A, Hansen KW, Nielsen S, Pedersen MM: Microalbuminuria and potential confounders. A review and some observations on variability of urinary albumin excretion. Diabetes Care 1995; 18: 572-581.
5. Mattix HJ, Hsu CY, Shaykevich S, Curhan G: Use of the albumin/creatinine ratio to detect microalbuminuria: implications of sex and race. J Am Soc Nephrol 2002; 13: 1034-1039.
6. Giorgino F, Laviola L, Cavallo Perin P, Solnica B, Fuller J, Chaturvedi N: Factors associated with progression to macroalbuminuria in microalbuminuric type 1 diabetic patients: the EURODIAB Prospective Complications Study. Diabetologia 2004; 47: 1020-1028.
7. Perkins BA, Ficociello LH, Silva KH, Finkelstein DM, Warram JH, Krolewski AS: Regression of microalbuminuria in type 1 diabetes. N Engl J Med 2003; 348: 2285-2293.
8. Rosolowsky ET, Niewczas MA, Ficociello LH, Perkins BA, Warram JH, Krolewski AS: Between hyperfiltration and impairment: demystifying early renal functional changes in diabetic nephropathy. Diabetes Res Clin Pract 2008; 82(suppl 1):S46-S53.
9. Ismail N, Becker B, Strzelczyk P, Ritz E: Renal disease and hypertension in non-insulindependent diabetes mellitus. Kidney Int 1999; 55: 1-28.
10. Mogensen CE: Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. N Engl J Med 1984; 310: 356-360.
11. Klein R, Klein BE, Moss SE, Cruickshanks KJ: Ten-year incidence of gross proteinuria in people with diabetes. Diabetes 1995; 44: 916-923.
12. MacIsaac RJ, Tsalamandris C, Panagiotopoulos S, Smith TJ, McNeil KJ, Jerums G: Nonalbuminuric renal insufficiency in type 2 diabetes. Diabetes Care 2004; 27: 195-200.
13. Macisaac RJ, Jerums G: Albuminuric and non-albuminuric pathways to renal impairment in diabetes. Minerva Endocrinol 2005; 30: 161-177.
14. Jerums G, Premaratne E, Panagiotopoulos S, Clarke S, Power DA, MacIsaac RJ: New and old markers of progression of diabetic nephropathy. Diabetes Res Clin Pract 2008; 82(suppl 1):S30-S37.
15. Araki S, Haneda M, Koya D, Kashiwagi A, Uzu T, Kikkawa R: Clinical impact of reducing microalbuminuria in patients with type 2 diabetes mellitus. Diabetes Res Clin Pract 2008; 82(suppl 1):S54-S58.
16. Tomino Y, Suzuki S, Azushima C, Shou I, Iijima T, Yagame M, Wang LN, Chen HC, Lai KN, Tan SY, Kim MJ: Asian multicenter trials on urinary type IV collagen in patients with diabetic nephropathy. J Clin Lab Anal 2001; 15: 188-192.
17. Okonogi H, Nishimura M, Utsunomiya Y, Hamaguchi K, Tsuchida H, Miura Y, Suzuki S, Kawamura T, Hosoya T, Yamada K: Urinary type IV collagen excretion reflects renal morphological alterations and type IV collagen expression in patients with type 2 diabetes mellitus. Clin Nephrol 2001; 55: 357-364.
18. Sundberg AG, Appelkvist EL, Backman L, Dallner G: Urinary pi-class glutathione transferase as an indicator of tubular damage in the human kidney. Nephron 1994; 67: 308-316.
19. Shaw M: The use of histologically defined specific biomarkers in drug development with special reference to the glutathione Stransferases. Cancer Biomark 2005; 1: 69-74.
20. Daemen JW, Oomen AP, Janssen MA, van de Schoot L, van Kreel BK, Heineman E, Kootstra G: Glutathione S-transferase as predictor of functional outcome in transplantation of machine-preserved non-heart-beating donor kidneys. Transplantation 1997; 63: 89-93.
21. Maxwell PR, Gordon D, Coyle A: Differentiation between Renal Injury and Compensatory Responses by the Use of Specific Biomarkers; PhD Thesis. Stobhill Hospital Glasgow UK & Biotrin International Ltd, Dublin, 1999.
22. Sundberg AG, Nilsson R, Appelkvist EL, Dallner G: ELISA procedures for the quantitation of glutathione transferases in the urine. Kidney Int 1995; 48: 570-575.
23. Branten AJ, Mulder TP, Peters WH, Assmann KJ, Wetzels JF: Urinary excretion of glutathione S-transferases alpha and pi in patients with proteinuria: reflection of the site of tubular injury. Nephron 2000; 85: 120-126.
24. Mauer SM, Steffes MW, Goetz FC, Sutherland DE, Brown DM: Diabetic nephropathy. A perspective. Diabetes 1983; 32(suppl 2):52-55.
25. Mauer SM, Steffes MW, Ellis EN, Sutherland DE, Brown DM, Goetz FC: Structural-functional relationships in diabetic nephropathy. J Clin Invest 1984; 74: 1143-1155.