Suppressive effect of glucocorticoids on TNF-α production is associated with their clinical effect in multiple sclerosis

Multiple Sclerosis

Volumn 16, Issue 4, 2010, Pages 500-502

  Van Winsen, Lisa M L ^a   Polman, Chris H ^a   Dijkstra, Christine D ^b   Tilders, Fred J H ^b   Uitdehaag, Bernard M J ^a,b  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Corticosteroids; Cytokines; Multiple sclerosis; Treatment response

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID; METHYLPREDNISOLONE; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; BIOLOGICAL MARKER;

ADULT; ARTICLE; CLINICAL ARTICLE; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG EFFICACY; DRUG MEGADOSE; FEMALE; HUMAN; IN VITRO STUDY; MALE; MORNING DOSAGE; MULTIPLE SCLEROSIS; PROSPECTIVE STUDY; BLOOD; CLINICAL TRIAL; DISABILITY; DOSE RESPONSE; DOWN REGULATION; DRUG RESISTANCE; IMMUNOLOGY; MIDDLE AGED; MONONUCLEAR CELL; TREATMENT OUTCOME;

ADULT; BIOLOGICAL MARKERS; DEXAMETHASONE; DISABILITY EVALUATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; DRUG RESISTANCE; FEMALE; GLUCOCORTICOIDS; HUMANS; INFLAMMATION MEDIATORS; LEUKOCYTES, MONONUCLEAR; MALE; METHYLPREDNISOLONE; MIDDLE AGED; MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; PROSPECTIVE STUDIES; TREATMENT OUTCOME; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77954662767     PISSN: 13524585     EISSN: None     Source Type: Journal    
DOI: 10.1177/1352458509359721     Document Type: Article

References (2)

1. Filippini G, Brusaferri F, Sibley WA, et al. Corticosteroids or ACTH for acute exacerbations in multiple sclerosis. Cochrane Database Syst Rev 2000; CD001331.
2. Van Winsen LM, Muris DF, Polman CH, Dijkstra CD, van den Berg TK, Uitdehaag BM. Sensitivity to glucocorticoids is decreased in relapsing remitting multiple sclerosis. J Clin Endocrinol Metab 2005;90:734-740.