Mitogen-activated protein kinases pathway is involved in physiological testosterone-induced tissue factor pathway inhibitor expression in endothelial cells

Blood Coagulation and Fibrinolysis

Volumn 21, Issue 5, 2010, Pages 420-424

  Jin, Hong ^a   Wang, Da Yu ^b   Mei, Yi Fang ^c   Qiu, Wen Bing ^a   Zhou, Yi ^a   Wang, Dong Ming ^a   Tan, Xue Rui ^a   Li, Yu Guang ^a  

^a SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^b Panyu Area Central Hospital   (China)

^c HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Human umbilical vein endothelial cell; mitogen activated protein kinases; testosterone; thrombosis; tissue factor pathway inhibitor

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; FLUTAMIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; TESTOSTERONE; TISSUE FACTOR PATHWAY INHIBITOR;

ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

CELLS, CULTURED; ENDOTHELIAL CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; HUMANS; LIPOPROTEINS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TESTOSTERONE; THROMBOSIS;

EID: 77954661260     PISSN: 09575235     EISSN: None     Source Type: Journal    
DOI: 10.1097/MBC.0b013e328337b475     Document Type: Article

References (23)

1. Choi BG, McLaughlin MA. Why men's hearts break: cardiovascular effects of sex steroids. Endocrinol Metab Clin North Am 2007; 36: 365-377.
2. Wu FC. Endocrine aspects of anabolic steroids. Clin Chem 1997; 43:1289-1292.
3. Jones RD, Nettleship JE, Kapoor D, Jones HT, Channer KS. Testosterone and atherosclerosis in aging men: purported association and clinical implications. Am J Cardiovasc Drugs 2005; 5:141-154.
4. Smith AM, English KM, Malkin CJ, Jones RD, Jones TH, Channer KS. Testosterone does not adversely affect fibrinogen or tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) levels in men with chronic stable angina. Eur J Endocrinol 2005; 152:285-291.
5. Li S, Li X, Li J, Deng X, Li Y. Inhibition of oxidative-stress-induced platelet aggregation by androgen at physiological levels via its receptor is associated with the reduction of thromboxane A2 release from platelets. Steroids 2007; 72:875-880.
6. Hak AE, Witteman JC, de Jong FH, Geerlings MI, Hofman A, Pols HA. Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: the Rotterdam study. J Clin Endocrinol Metab 2002; 87:3632-3639.
7. Hakimian P, Blute M Jr, Kashanian J, Chan S, Silver D, Shabsigh R. Metabolic and cardiovascular effects of androgen deprivation therapy. BJU Int 2008; 102:1509-1514.
8. Francischetti IM, Mather TN, Ribeiro JM. Penthalaris, a novel recombinant five-Kunitz tissue factor pathway inhibitor (TFPI) from the salivary gland of the tick vector of Lyme disease, Ixodes scapularis. Thromb Haemost 2004; 91:886-898.
9. Broze GJ Jr. Tissue factor pathway inhibitor and the revised theory of coagulation. Annu Rev Med 1995; 46:103-112.
10. Maroney SA, Cooley BC, Sood R, Weiler H, Mast AE. Combined tissue factor pathway inhibitor and thrombomodulin deficiency produces an augmented hypercoagulable state with tissue-specific fibrin deposition. J Thromb Haemost 2008; 6:111-117.
11. Hoke M, Kyrle PA, Minar E, Bialonzcyk C, Hirschl M, Schneider B, et al. Tissue factor pathway inhibitor and the risk of recurrent venous thromboembolism. Thromb Haemost 2005; 94:787-790. (Pubitemid 41489238)
12. Jin H, Lin J, Fu L, Mei YF, Peng G, Tan X, et al. Physiological testosterone stimulates tissue plasminogen activator and tissue factor pathway inhibitor and inhibits plasminogen activator inhibitor type 1 release in endothelial cells. Biochem Cell Biol 2007; 85:246-251.
13. Evans RM. The steroid and thyroid hormone receptor superfamily. Science 1988; 240:889-895.
14. Gatson JW, Singh M. Activation of a membrane-associated androgen receptor promotes cell death in primary cortical astrocytes. Endocrinology 2007; 148:2458-2464.
15. Cheng J, Watkins SC, Walker WH. Testosterone activates mitogenactivated protein kinase via Src kinase and the epidermal growth factor receptor in sertoli cells. Endocrinology 2007; 148:2066-2074.
16. Furie B, Furie BC. The molecular basis of blood coagulation. Cell 1988; 53:505-518.
17. Benten WP, Guo Z, Krücken J, Wunderlich F. Rapid effects of androgens in macrophages. Steroids 2004; 69:585-590.
18. Guo Z, Benten WP, Krücken J, Wunderlich F. Nongenomic testosterone calcium signaling. Genotropic actions in androgen receptor-free macrophages. J Biol Chem 2002; 277:29600-29607. (Pubitemid 41079249)
19. Migliaccio A, Domenico M, Castoria G, de Falco A, Bontempo P, Nola E, Auricchio F. Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells. EMBO J 1996; 15:1292-1300.
20. Castoria G, Barone MV, Di Domenico M, Bilancio A, Ametrano D, Migliaccio A, Auricchio F. Nontranscriptional action of oestradiol and progestin triggers DNA synthesis. EMBO J 1999; 18:2500-2510.
21. Vera Y, ErkkiläK, Wang C, Nunez C, Kyttänen S, Lue Y, et al. Involvement of p38 mitogen-activated protein kinase and inducible nitric oxide synthase in apoptotic signaling of murine and human male germ cells after hormone deprivation. Mol Endocrinol 2006; 20:1597-1609.
22. Jin H, Zhang XY, Peng G, Qiu WB, Wang DM, Li YG. Effects of testosterone on extracellular signal-regulated kinase 1/2 phosphorylation in human umbilical vein endothelial cells. Zhonghua Nan Ke Xue 2007; 13:777-779.
23. Zouki C, Zhang SL, Chan JS, Filep JG. Peroxynitrite induces integrindependent adhesion of human neutrophils to endothelial cells via activation of the Raf-1/MEK/Erk pathway. FASEB J 2001; 15:25-27.