Structural, NMR spectroscopic, and computational investigation of hemin loading in the hemophore hasap from pseudomonas aeruginosa

Journal of the American Chemical Society

Volumn 132, Issue 28, 2010, Pages 9857-9872

  Jepkorir, Grace ^a   Rodríguez, Juan Carlos ^a   Rui, Huan ^a   Im, Wonpil ^a   Lovell, Scott ^a   Battaile, Kevin P ^c   Alontaga, Aileen Y ^a   Yukl, Erik T ^b   Moënne Loccoz, Pierre ^b   Rivera, Mario ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AXIAL LIGAND; COMPUTATIONAL INVESTIGATION; CONFORMATIONAL CHANGE; CONFORMATIONAL HETEROGENEITY; DYNAMIC PROCESS; EXPERIMENTAL EVIDENCE; GRAM-NEGATIVE PATHOGENS; MOLECULAR MOTIONS; NMR SPECTROSCOPY; NMR STUDIES; OUTER MEMBRANE; P.AERUGINOSA; PSEUDOMONAS AERUGINOSA; TARGETED MOLECULAR DYNAMICS; WILD TYPES; X-RAY STRUCTURE;

CONFORMATIONS; LIGANDS; LOADING; MOLECULAR DYNAMICS; MONOMERS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OLIGOMERS;

CRYSTAL STRUCTURE;

BACTERIAL PROTEIN; HASAP PROTEIN; HEMIN; HISTIDINE; IMIDAZOLE; MONOMER; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL INTERACTION; CHEMICAL REACTION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DIMERIZATION; ELECTRON SPIN RESONANCE; HETERONUCLEAR SINGLE QUANTUM COHERENCE; MOLECULAR DYNAMICS; MOLECULE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; RAMAN SPECTROMETRY; WILD TYPE;

BACTERIAL PROTEINS; CARRIER PROTEINS; HEMIN; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PSEUDOMONAS AERUGINOSA; X-RAY DIFFRACTION;

EID: 77954655560     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja103498z     Document Type: Article

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