Clinical, molecular and epidemiological description of a cluster of community-associated methicillin-resistant Staphylococcus aureus isolates from injecting drug users with bacteraemia

Clinical Microbiology and Infection

Volumn 16, Issue 7, 2010, Pages 921-926

  Cooke, F J ^a   Gkrania Klotsas, E ^b   Howard, J C ^a   Stone, M ^c   Kearns, A M ^a   Ganner, M ^a   Carmichael, A J ^b   Brown, N M ^a  

^a PUBLIC HEALTH ENGLAND   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Bacteraemia; Community; Drug users; Epidemiology; MRSA

Indexed keywords

CIPROFLOXACIN; CLINDAMYCIN; DOXYCYCLINE; ERYTHROMYCIN; FLUCLOXACILLIN; FUSIDIC ACID; RIFAMPICIN; TEICOPLANIN; VANCOMYCIN;

ADULT; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTEREMIA; BACTERIOPHAGE TYPING; BLOOD CULTURE; CANDIDA; CASE REPORT; CELLULITIS; CLINICAL FEATURE; DRUG SUBSTITUTION; DRUG WITHDRAWAL; GENOTYPE; HOSPITAL READMISSION; HUMAN; INTRAVENOUS DRUG ABUSE; LUNG ABSCESS; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MINIMUM INHIBITORY CONCENTRATION; MULTILOCUS SEQUENCE TYPING; NEUTROPENIA; OSTEOMYELITIS; PLEURA EFFUSION; POLYMERASE CHAIN REACTION; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; STREPTOCOCCUS GROUP A; UNITED KINGDOM;

METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS;

EID: 77954644426     PISSN: 1198743X     EISSN: 14690691     Source Type: Journal    
DOI: 10.1111/j.1469-0691.2009.02969.x     Document Type: Article

References (28)

1. Diep BA, Chambers HF, Graber CJ. Emergence of multidrug-resistant, community-associated, methicillin-resistant Staphylococcus aureus clone USA300 in men who have sex with men. Ann Intern Med 2008, 148:249-257.
2. Pan ES. Increasing prevalence of methicillin-resistant Staphylococcus aureus infection in California jails. Clin Infect Dis 2003, 37:1384-1388.
3. Thomas S, Karas JA, Emery M, Clark G. Meticillin-resistant Staphylococcus aureus carriage among district nurse patients and medical admissions in a UK district. J Hosp Infect 2007, 66:369-373.
4. Huang H, Cohen SH, King JH, Monchaud C, Nguyen H, Flynn NM. Injecting drug use and community-associated methicillin-resistant Staphylococcus aureus infection. Diagn Microbiol Infect Dis 2008, 60:347-350.
5. Cooke FJ, Howard JC, Hugh-Jones C, Brown NM. Meticillin-resistant Staphylococcus aureus in the community: homeless are also at risk. J Hosp Infect 2008, 68:186-188.
6. Abudu L, Blair I, Fraise A, Cheng KK. Methicillin-resistant Staphylococcus aureus (MRSA): a community-based prevalence survey. Epidemiol Infect 2001, 126:351-356.
7. Maudsley J, Stone S, Kibbler CC. The community prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in older people living in their own homes: implications for treatment, screening and surveillance in the UK. J Hosp Infect 2004, 57:258-262.
8. Davis SL, Perri MB, Donabedian SM. Epidemiology and outcomes of community-associated methicillin-resistant Staphylococcus aureus infection. J Clin Microbiol 2007, 45:1705-1711.
9. Community MRSA in England and Wales: definition through strain characterization. CDR Wkly 2005, 15. Health Protection Agency
10. Klevens RM, Gorwirtz RJ, Collins AS. Community-associated methicillin-resistant Staphylococcus aureus and healthcare risk factors. Emerg Infect Dis 2006, 12:1991-1993.
11. Methicillin resistant Staphylococcus aureus (MRSA) in injecting drug users. CDR Wkly 2003, 13(suppl 27). Health Protection Agency
12. Kearns AM, Rathmann IR, Holmes A, Pitt TL, Cookson BD. An unusual clone of MRSA causing infection in injecting drug users. J Infect 2004, 49:49-50.
13. Shooting up: infections among injecting drug users in the United Kingdom 2007 2008, Health Protection Agency, H.P.S., National Public Health Service for Wales, CDSC Northern Ireland, and the CRDHB, London, Health Protection Agency
14. Andrews JM. BSAC standardized disc susceptibility testing method. J Antimicrob Chemother 2001, 48(suppl 1):43-57.
15. Holmes A, Ganner M, McGuane S, Pitt TL, Cookson BD, Kearns AM. Staphylococcus aureus isolates carrying Panton-Valentine leucocidin genes in England and Wales: frequency, characterization, and association with clinical disease. J Clin Microbiol 2005, 43:2384-2390.
16. Zhang K, McClure JA, Elsayed S, Louie T, Conly JM. Novel multiplex PCR assay for characterization and concomitant subtyping of staphylococcal cassette chromosome mec types I to V in methicillin-resistant Staphylococcus aureus. J Clin Microbiol 2005, 43:5026-5033.
17. Enright MC, Day NP, Davies CE, Peacock SJ, Spratt BG. Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus. J Clin Microbiol 2000, 38:1008-1015.
18. Otter JA, French GL. Community-associated meticillin-resistant Staphylococcus aureus in injecting drug users and the homeless in south London. J Hosp Infect 2008, 69:198-200.
19. Corkill JE, Anson JJ, Griffiths P, Hart CA. Detection of elements of the staphylococcal cassette chromosome (SCC) in a methicillin-susceptible (mecA gene negative) homologue of a fucidin-resistant MRSA. J Antimicrob Chemother 2004, 54:229-231.
20. Jukka C, S Al-Abri, Anson J, Corkill J, Curnow J, Beeching NJ. A cluster of community acquired bacteraemias in an intravenous drug-using population due to a novel clonal strain of meticillin-resistant Staphylococcus aureus. Clin Microbiol Infect 2004, 10(suppl 3):24.
21. Tenover FC, Arbeit RD, Goering RV, Mickelsen PA, Murray BE, Persing DH, Swaminathan B. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol 1995, 33:2233-2239.
22. Coombs GW, Nimmo GR, Bell JM. Genetic diversity among community methicillin-resistant Staphylococcus aureus strains causing outpatient infections in Australia. J Clin Microbiol 2004, 42:4735-4743.
23. Otter JA, Klein JL, Watts TL, Kearns AM, French GL. Identification and control of an outbreak of ciprofloxacin-susceptible EMRSA-15 on a neonatal unit. J Hosp Infect 2007, 67:232-239.
24. David MD, Kearns AM, Gossain S, Ganner M, Holmes A. Community-associated meticillin-resistant Staphylococcus aureus: nosocomial transmission in a neonatal unit. J Hosp Infect 2006, 64:244-250.
25. Seetulsingh P, Curtis C, Kearns AM. Outbreak of ciprofloxacin-susceptible community-associated meticillin-resistant Staphylococcus aureus in a neonatal unit. J Hosp Infect 2008, 68:374-375.
26. Otter JA, French GL. The emergence of community-associated methicillin-resistant Staphylococcus aureus at a London teaching hospital, 2000-2006. Clin Microbiol Infect 2008, 14:670-676.
27. Shooting up. Infections among injecting drug users in the United Kingdom 2006. An update: October 2007 2007, Health Protection Agency
28. Hanssen AM, Kjeldsen G, Sollid JU. Local variants of Staphylococcal cassette chromosome mec in sporadic methicillin-resistant Staphylococcus aureus and methicillin-resistant coagulase-negative Staphylococci: evidence of horizontal gene transfer? Antimicrob Agents Chemother 2004, 48:285-296.