Response to Rv2628 latency antigen associates with cured tuberculosis and remote infection

European Respiratory Journal

Volumn 36, Issue 1, 2010, Pages 135-142

  Goletti, D ^a   Butera, O ^a   Vanini, V ^a   Lauria, F N ^b   Lange, C ^c   Franken, K L M C ^d   Angeletti, C ^a   Ottenhoff, T H M ^d   Girardi, E ^a  

^a Translational Research Unit Dept of Epidemiology and Preclinical Research ^*  (Italy)

^b NATIONAL INSTITUTE FOR INFECTIOUS DISEASES L SPALLANZANI   (Italy)

^c RESEARCH CENTER BORSTEL   (Germany)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Diagnostics; Dormancy; Recent tuberculosis infection; Remote latent tuberculosis infection; Tuberculosis

Indexed keywords

ANTIGEN; GAMMA INTERFERON; BACTERIAL ANTIGEN; BACTERIAL PROTEIN; DOSR PROTEIN, MYCOBACTERIUM TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS ANTIGENS; PROTEIN KINASE;

ADULT; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; FEMALE; HUMAN; LATENT PERIOD; MAJOR CLINICAL STUDY; MALE; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; T LYMPHOCYTE; TUBERCULOSIS; GENETICS; IMMUNOLOGY; LATENT TUBERCULOSIS;

ADULT; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; FEMALE; HUMANS; INTERFERON-GAMMA; LATENT TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS; PROTEIN KINASES; T-LYMPHOCYTES;

EID: 77954642578     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00140009     Document Type: Article

References (31)

1. World Health Organization, Global Tuberculosis Control 2008. Surveillance, Planning, Financing. Geneva, World Health Organization, 2008.
2. Pai M, Zwerling A, Menzies D. Systematic review: T-cell-based assays for the diagnosis of latent tuberculosis infection: an update. Ann Intern Med 2008; 149: 177-184.
3. Lalvani A. Diagnosing tuberculosis infection in the 21st century: new tools to tackle an old enemy. Chest 2007; 131: 1898-1906. (Pubitemid 46981652)
4. Ferrara G, Losi M, Meacci M, et al. Routine hospital use of a new commercial whole blood interferon-γ assay for the diagnosis of tuberculosis infection. Am J Respir Crit Care Med 2005; 172: 631-635.
5. Goletti D, Stefania C, Butera O, et al. Accuracy of immunodiagnostic tests for active tuberculosis using single and combined results: a multicenter TBNET-Study. PLoS One 2008; 3: e3417.
6. Goletti D, Carrara S, Vincenti D, et al. Accuracy of an immune diagnostic assay based on RD1 selected epitopes for active tuberculosis in a clinical setting: a pilot study. Clin Microbiol Infect 2006; 12: 544-550. (Pubitemid 43740765)
7. Goletti D, Parracino MP, Butera O, et al. Isoniazid prophylaxis differently modulates T-cell responses to RD1-epitopes in contacts recently exposed to Mycobacterium tuberculosis: a pilot study. Respir Res 2007; 8: 5.
8. Marais BJ, Gie RP, Schaaf HS, et al. Childhood pulmonary tuberculosis: old wisdom and new challenges. Am J Respir Crit Care Med 2006; 173: 1078-1090.
9. Ulrichs T, Kosmiadi GA, Trusov V, et al. Human tuberculous granulomas induce peripheral lymphoid follicle-like structures to orchestrate local host defence in the lung. J Pathol 2004; 204: 217-228. (Pubitemid 39335296)
10. Wayne LG, Hayes LG. Nitrate reduction as a marker for hypoxic shiftdown of Mycobacterium tuberculosis. Tuber Lung Dis 1998; 79: 127-132.
11. Tufariello JM, Chan J, Flynn JL. Latent tuberculosis: mechanisms of host and bacillus that contribute to persistent infection. Lancet Infect Dis 2003; 3: 578-590. (Pubitemid 37064537)
12. Yuan Y, Crane DD, Barry CE III. Stationary phase-associated protein expression in Mycobacterium tuberculosis: function of the mycobacterial α-crystallin homolog. J Bacteriol 1996; 178: 4484-4492. (Pubitemid 26262233)
13. Park HD, Guinn KM, Harrell MI, et al. Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis. Mol Microbiol 2003; 48: 833-843.
14. Leyten EM, Lin MY, Franken KL, et al. Human T-cell responses to 25 novel antigens encoded by genes of the dormancy regulon of Mycobacterium tuberculosis. Microbes Infect 2006; 8: 2052-2060.
15. Schuck SD, Mueller H, Kunitz F, et al. Identification of T-cell antigens specific for latent Mycobacterium tuberculosis infection. PLoS One 2009; 4: e5590.
16. Black GF, Thiel BA, Ota M, et al. Immunogenicity of novel DosR regulon-encoded candidate antigens of Mycobacterium tuberculosis in three high-burden populations in Africa. Clin Vaccine Immunol 2009; 16: 1203-1212.
17. Weir RE, Gorak-Stolinska P, Floyd S, et al. Persistence of the immune response induced by BCG vaccination. BMC Infect Dis 2008; 8: 9. (Pubitemid 351359616)
18. Lawn SD, Bangani N, Vogt M, et al. Utility of interferon-γ ELISPOT assay responses in highly tuberculosis-exposed patients with advanced HIV infection in South Africa. BMC Infect Dis 2007; 7: 99.
19. Geluk A, Lin MY, van Meijgaarden KE, et al. T-cell recognition of the HspX protein of Mycobacterium tuberculosis correlates with latent M. tuberculosis infection but not with M. bovis BCG vaccination. Infect Immun 2007; 75: 2914-2921.
20. National Collaborating Centre for Chronic Conditions. Tuberculosis: Clinical Diagnosis and Management of Tuberculosis, and Measures for its Prevention and Control. London, Royal College of Physicians, 2006.
21. Franken KL, Hiemstra HS, van Meijgaarden KE, et al. Purification of His-tagged proteins by immobilized chelate affinity chromatography: the benefits from the use of organic solvent. Protein Expr Purif 2000; 18: 95-99.
22. Diagnostic standards and classification of tuberculosis in adults and children. Am J Respir Crit Care Med 2000; 161: 1376-1395.
23. Voskuil MI, Schnappinger D, Visconti KC, et al. Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program. J Exp Med 2003; 198: 705-713. (Pubitemid 37087770)
24. Schnappinger D, Ehrt S, Voskuil MI, et al. Transcriptional adaptation of Mycobacterium tuberculosis within macrophages: insights into the phagosomal environment. J Exp Med 2003; 198: 693-704.
25. Demissie A, Leyten EM, Abebe M, et al. Recognition of stage-specific mycobacterial antigens differentiates between acute and latent infections with Mycobacterium tuberculosis. Clin Vaccine Immunol 2006; 13: 179-186.
26. Roupie V, Romano M, Zhang L, et al. Immunogenicity of eight dormancy regulon-encoded proteins of Mycobacterium tuberculosis in DNA-vaccinated and tuberculosis-infected mice. Infect Immun 2007; 75: 941-949. (Pubitemid 46203459)
27. Shi L, Jung YJ, Tyagi S, et al. Expression of Th1-mediated immunity in mouse lungs induces a Mycobacterium tuberculosis transcription pattern characteristic of nonreplicating persistence. Proc Natl Acad Sci USA 2003; 100: 241-246. (Pubitemid 36078059)
28. Boon C, Li R, Qi R, et al. Proteins of Mycobacterium bovis BCG induced in the Wayne dormancy model. J Bacteriol 2001; 183: 2672-2676. (Pubitemid 32249778)
29. Mayuri, Bagchi G, Das TK, et al. Molecular analysis of the dormancy response in Mycobacterium smegmatis: expression analysis of genes encoding the DevR-DevS two-component system, Rv3134c and chaperone alpha-crystallin homologues. FEMS Microbiol Lett 2002; 211: 231-237.
30. Lin MY, Reddy TK, Arend SM, et al. Cross-reactive immunity to Mycobacterium tuberculosis DosR regulon-encoded antigens in individuals infected with environmental, nontuberculous mycobacteria. Infect Immun 2009; 77: 5071-5079.
31. Lin MY, Ottenhoff TH. Host-pathogen interactions in latent Mycobacterium tuberculosis infection: identification of new targets for tuberculosis intervention. Endocr Metab Immune Disord Drug Targets 2008; 8: 15-29.