Generation of Fgfr3 conditional knockout mice

International Journal of Biological Sciences

Volumn 6, Issue 4, 2010, Pages 327-332

  Su, Nan ^a   Xu, Xiaoling ^b   Li, Cuiling ^b   He, Qifen ^a   Zhao, Ling ^a   Li, Can ^a   Chen, Siyu ^a   Luo, Fengtao ^a   Yi, Lingxian ^a   Du, Xiaolan ^a   Huang, Haiyang ^a   Deng, Chuxia ^b   Chen, Lin ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Conditional knock out; Cre Loxp; FGFR3; Gene targeting

Indexed keywords

ANIMALIA; MURINAE; MUS;

FIBROBLAST GROWTH FACTOR RECEPTOR 3;

ANIMAL; ELECTROPORATION; GENETICS; GENOTYPE; KNOCKOUT MOUSE; MOUSE; MUTATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ELECTROPORATION; GENOTYPE; MICE; MICE, KNOCKOUT; MUTATION; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 3; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 77954631436     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.6.327     Document Type: Article

References (26)

1. Ornitz DM and Marie PJ. FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease. Genes Dev, 2002; 16: 1446-1465.
2. Colvin JS, Bohne BA, Harding GW et al. Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3. Nat Genet, 1996; 12: 390-397.
3. Deng C, Wynshaw-Boris A, Zhou F et al. Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell, 1996; 84: 911-921
4. Shiang R, Thompson LM, Zhu YZ et al. Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia. Cell, 1994; 78: 335-342.
5. Rousseau F, Bonaventure J, Legeai-Mallet L et al. Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia. Nature, 1994; 371: 252-254.
6. Tavormina PL, Shiang R, Thompson LM et al. Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3. Nat Genet, 1995; 9: 321-328.
7. Bonaventure J, Rousseau F, Legeai-Mallet L et al. Common mutations in the fibroblast growth factor receptor 3 (FGFR 3) gene account for achondroplasia, hypochondroplasia, and thanatophoric dwarfism. Am J Med Genet, 1996; 63: 148-154.
8. Naski MC and Ornitz DM. FGF signaling in skeletal development. Front Biosci, 1998; 3: d781-794.
9. Su N, Du X and Chen L. FGF signaling: its role in bone development and human skeleton diseases. Front Biosci, 2008; 13: 2842-2865.
10. Toydemir RM, Brassington AE, Bayrak-Toydemir P et al. A novel mutation in FGFR3 causes camptodactyly, tall stature, and hearing loss (CATSHL) syndrome. Am J Hum Genet, 2006; 79: 935-941.
11. Chellaiah AT, McEwen DG, Werner S et al. Fibroblast growth factor receptor (FGFR) 3. Alternative splicing in immunoglobulinlike domain III creates a receptor highly specific for acidic FGF/FGF-1. J Biol Chem, 1994; 269: 11620-11627.
12. Pringle NP, Yu WP, Howell M et al. Fgfr3 expression by astrocytes and their precursors: evidence that astrocytes and oligodendrocytes originate in distinct neuroepithelial domains. Development, 2003; 130: 93-102.
13. Patstone G, Pasquale EB and Maher PA. Different members of the fibroblast growth factor receptor family are specific to distinct cell types in the developing chicken embryo. Dev Biol, 1993; 155: 107-123.
14. Vidrich A, Buzan JM, Ilo C et al. Fibroblast growth factor receptor3 is expressed in undifferentiated intestinal epithelial cells during murine crypt morphogenesis. Dev Dyn, 2004; 230: 114-123.
15. Wang JM, Du XL, Li CL et al. [Gly374Arg mutation in Fgfr3 causes achondroplasia in mice.]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2004; 21: 537-541.
16. Chen L, Adar R, Yang X et al. Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis. J Clin Invest, 1999; 104: 1517-1525.
17. Li C, Chen L, Iwata T et al. A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors. Hum Mol Genet, 1999; 8: 35-44.
18. Eswarakumar VP and Schlessinger J. Skeletal overgrowth is mediated by deficiency in a specific isoform of fibroblast growth factor receptor 3. Proc Natl Acad Sci U S A, 2007; 104: 3937-3942.
19. Valverde-Franco G, Binette JS, Li W et al. Defects in articular cartilage metabolism and early arthritis in fibroblast growth factor receptor 3 deficient mice. Hum Mol Genet, 2006; 15: 1783-1792.
20. Valverde-Franco G, Liu H, Davidson D et al. Defective bone mineralization and osteopenia in young adult FGFR3-/- mice. Hum Mol Genet, 2004; 13: 271-284.
21. Puligilla C, Feng F, Ishikawa K et al. Disruption of fibroblast growth factor receptor 3 signaling results in defects in cellular differentiation, neuronal patterning, and hearing impairment. Dev Dyn, 2007; 236: 1905-1917.
22. Wuchner C, Hilbert K, Zabel B et al. Human fibroblast growth factor receptor 3 gene (FGFR3): genomic sequence and primer set information for gene analysis. Hum Genet, 1997; 100: 215-219.
23. L'Hote CG and Knowles MA. Cell responses to FGFR3 signalling: growth, differentiation and apoptosis. Exp Cell Res, 2005; 304: 417-431.
24. Xu X, Qiao W, Li C et al. Generation of Fgfr1 conditional knockout mice. Genesis, 2002; 32: 85-86.
25. Lakso M, Pichel JG, Gorman JR et al. Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci U S A, 1996; 93: 5860-5865.
26. Xu X, Li C, Garrett-Beal L et al. Direct removal in the mouse of a floxed neo gene from a three-loxP conditional knockout allele by two novel approaches. Genesis, 2001; 30: 1-6.