Planar differential mobility spectrometer as a pre-filter for atmospheric pressure ionization mass spectrometry

International Journal of Mass Spectrometry

Volumn 298, Issue 1-3, 2010, Pages 45-54

  Schneider, Bradley B ^a   Covey, Thomas R ^a   Coy, Stephen L ^b   Krylov, Evgeny V ^b   Nazarov, Erkinjon G ^b  

^a MDS Analytical Technologies   (Canada)

^b Sionex Corporation   (United States)

Author keywords

Atmospheric pressure ion pre filtering; Differential mobility spectrometry; Ion mobility; Mass spectrometry; Modeling

Indexed keywords

EID: 77954625548     PISSN: 13873806     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijms.2010.01.006     Document Type: Article

References (40)

1. Krylov E.V., Nazarov E.G., Miller R.A. Differential mobility spectrometer: model of operation. Int. J. Mass Spectrom. 2007, 266:76-85.
2. Eiceman G., Karpas Z. Ion Mobility Spectrometry 2005, CRC Press, Taylor & Francis LLC, Boca Raton, FL. second ed.
3. Shvartsburg A.A. Differential Ion Mobility: Non-linear Ion Transport and Fundamentals of FAIMS, CRC Group 2008, Taylor & Francis LLC, Boca Raton, FL.
4. M.P. Gorshkov, Inventor's certificate of USSR No. 966583, G01N27/62 (1982).
5. Buryakov A., Krylov E.V., Makas A.L., Nazarov E.G., Pervukhin V.V., Rasulev U.Kh. Separation of ions according to mobility in a strong electric field. Sov. Tech. Phys. Lett. 1991, 17(6):446-447.
6. Buryakov I.A., Krylov E.V., Makas A.L., Nazarov E.G., Pervukhin V.V., Rasulev U.Kh. Drift spectrometer for the control of amine traces in the atmosphere. J. Anal. Chem. [Zhurnal Analiticheskoi Khimii] 1993, 48(2):114-121.
7. Buryakov I.A., Krylov E.V., Nazarov E.G., Rasulev U.Kh. A new method of separation of multi-atomic ions by mobility at atmospheric pressure using a high-frequency amplitude-asymmetric strong electric field. Int. J. Mass Spectrom. Ion Process. 1993, 128:143-148.
8. Makas A.L., Nazarov E.G., Pervukhin V.V., Rasulev U.Kh. Mass spectrometric investigation of the surface ionization of organic compounds at atmospheric pressure. Sov. Tech. Phys. Lett. 1990, 16(6):458-460.
9. Miller R.A., Nazarov E.G., Eiceman G.A., King A.T. A MEMS radio-frequency ion mobility spectrometer for chemical vapor detection. Sens. Actuators A 2001, 91:301-312.
10. Miller R.A., Eiceman G.A., Nazarov E.G., King A.T. A novel micromachined high-field asymmetric waveform-ion mobility spectrometer. Sens. Actuators B 2000, 67:300-306.
11. Krylov E.V. High voltage pulse generator. Instrum. Exp. Tech. 1991, 4:114-115.
12. Krylov E.V. Pulses of special shapes formed on a capacitive load. Instrum. Exp. Tech. 1997, 5:47-50.
13. Carnahan B., Day S., Kouznetsov V., Tarassov A. Development and applications of transverse field compensation ion mobility spectrometer. Proceeding of an Fourth International Workshop on Ion Mobility Spectrometry 1995.
14. Carnahan B., Day S., Kouznetsov V., Matyjaszczyk M., Tarassov A. Field ion spectrometry-a new analytical technology for trace gas analysis. Proceedings of the 41st Annual ISA Analysis Division Symposium, vol. 51(1) 1996, 87-96.
15. Verenchikov A.N., Krylov E.V., Louppou V.B., Makas A.L., Pervukhin V.V., Shkurov V.A. Analysis of ionic compositions of solutions using an ion gas analyzer. Chemical Analysis of Environment 1991, 127-133. Nauka, Novosibirsk. V.V. Malakhov (Ed.).
16. Purves R.W., Guevremont R. Electrospray ionization-high asymmetric waveform ion mobility spectrometry-mass spectrometry. Anal. Chem. 1999, 71:2346-2357.
17. Eiceman G.A., Nazarov E.G., Miller R.A. Micro-machined ion mobility spectrometer-mass spectrometer. Int. J. Ion Mobil. Spec. 2000, 3(1):15-27.
18. Levin D.S., Vouros P., Miller R.A., Nazarov E.G., Morris J.C. Characterization of gas phase molecular interactions on differential mobility ion behavior utilizing an electrospray ionization differential mobility mass spectrometry system. Anal. Chem. 2006, 78:96-106.
19. Shvartsburg A.A., Li F., Tang K., Smith R.D. High-resolution field asymmetric waveform ion mobility spectrometry using new planar geometry analyzers. Anal. Chem. 2006, 78:3706-3714.
20. Purves R.W., Guevremont R. Mass-spectrometric characterization of a high-field asymmetric waveform ion mobility spectrometer. Rev. Sci. Instrum. 1999, 69:4094-4105.
21. Eiceman G., Karpas Z. Ion Mobility Spectrometry 1993, CRC Press, Taylor & Francis LLC, Boca Raton, FL. first ed.
22. Revercomb H.E., Mason E.A. Theory of plasma chromatography/gaseous electrophoresis-a review. Anal. Chem. 1975, 47(7):970-983.
23. Carr T.W. Plasma Chromatography 1984, Plenum Press, New York.
24. Mason E.A., McDaniel E.W. Transport Properties of Ions in Gases 1988, John Wiley & Sons, NY.
25. Landgraf R.R., Hilton C.K., Yost R.A. Effect of carrier gas composition in ESI-FAIMS/MS on separation of charge states and conformers of intact proteins. 54th ASMS Conference Proceedings 2006.
26. Levin D.S., Miller R.A., Nazarov E.G., Vouros P. Rapid separation and quantitative analysis of peptides using a new nanoelectrospray-differential mobility spectrometer-mass spectrometer system. Anal. Chem. 2006, 78:5443-5452.
27. Levin D.S., Vouros P., Miller R.A., Nazarov E.G. Using a nanoelectrospray-differential mobility spectrometer system for the analysis of oligosaccharides with solvent selected control over ESI aggregate ion formation. Am. Soc. Mass Spectrom. 2007, 18:502-511.
28. Chernushevich I.V., Ens W., Standing K.G. Orthogonal injection TOF MS for analyzing biomolecules. Anal. Chem. 1999, 71:452A-461A.
29. Kanu A.B., Dwivedi P., Tarm M., Matz L., Hill H.H. Ion mobility-mass spectrometry. J. Mass Spectrom. 2008, 43:1-22.
30. Krylov E.V. A method of reducing diffusion losses in a drift spectrometer. Tech. Phys. Am. Inst. Phys. 1999, 44(1):113-136.
31. Guevremont R., Purves R.W. Atmospheric pressure ion focusing in a high field asymmetric waveform ion mobility spectrometer. Rev. Sci. Instrum. 1999, 70:1370-1383.
32. Schneider B.B., Covey T.R., Coy S.L., Krylov E.V., Nazarov E.G. Control of chemical effects in the separation process of a DMS/MS system. Eur. J. Mass Spectrom. 2010, 16:57-71.
33. Krylov E.V., Coy S.L., Vandermey J., Schneider B.B., Covey T.R., Nazarov E.G. Selection and generation of waveforms for differential mobility spectrometry. Rev. Sci. Inst. 2010, 81:1. 10.1063/1.3284507.
34. V. Kouznetsov, High voltage waveform generator, U.S. Patent 5,801,379 (1998).
35. Jugroot M., Groth C.P.T., Thomson B.A., Baranov V., Collings B.A. Numerical investigation of interface region flows in mass spectrometers: ion transport. J. Phys. D: Appl. Phys. 2004, 37:550-559.
36. Nazarov E.G., Miller R.A., Coy S.L., Krylov E., Kryuchkov S.I. Software simulation of ion motion in DC and AC electric fields including fluid-flow effects. (SIONEX microDMx SOFTWARE). Int. J. Ion Mobil. Spec. 2006, 9(1):35-39.
37. E.V. Krylov, Ion Mobility in Gases in a Moderate Strength Electric Fields, PhD Thesis, St.-Petersburg Polytechnic University, St.-Petersburg, Russia, 1995.
38. Kudryavtsev A., Makas A. Ion focusing in an ion mobility increment spectrometer (IMIS) with non-uniform electric fields: fundamental considerations. Int. J. Ion Mobil. Spec. 2001, 4(2):117-120.
39. Buryakov I.A. Ion mobility increment spectrometer with radial symmetry. Int. J. Ion Mobil. Spec. 2003, 6:1-7.
40. Schneider B.B., Javaheri H., Covey T.R. Ion sampling effects under conditions of total solvent consumption. Rapid Commun. Mass Spectrom. 2006, 20:1538-1544.