Autoimmunity to vimentin potentiates graft vasculopathy in murine cardiac allografts

Transplantation

Volumn 90, Issue 1, 2010, Pages 4-13

  Mahesh, Balakrishnan ^a,b   Leong, Hon Sing ^a,c   Nair, K Sukumaran ^a,d   McCormack, Ann ^a   Sarathchandra, Padmini ^a   Rose, Marlene L ^a  

^a HAREFIELD HOSPITAL   (United Kingdom)

^b NORFOLK AND NORWICH UNIVERSITY HOSPITAL   (United Kingdom)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

^d PAPWORTH HOSPITAL   (United Kingdom)

Author keywords

Antibody mediated rejection.; Autoimmunity; Chronic rejection; Graft vasculopathy; Vimentin

Indexed keywords

ALPHA ACTIN; AUTOANTIBODY; CD3 ANTIGEN; CD31 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; COMPLEMENT COMPONENT C3D; COMPLEMENTARY DNA; FREUND ADJUVANT; GAMMA INTERFERON; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; LYSOZYME; PADGEM PROTEIN; RECOMBINANT VIMENTIN; UNCLASSIFIED DRUG; VIMENTIN; VIMENTIN ANTIBODY;

ACUTE GRAFT REJECTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; AUTOIMMUNITY; C57BL 6 MOUSE; CARDIAC ALLOGRAFT VASCULOPATHY; CONFOCAL LASER MICROSCOPY; CONJUGATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DBA 1 MOUSE; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LINKED IMMUNOSPOT ASSAY; FLOW CYTOMETRY; HEART TRANSPLANTATION; HETEROTOPIC TRANSPLANTATION; HLA MATCHING; IMMUNIZATION; IMMUNOHISTOCHEMISTRY; LEUKOCYTE; MALE; MORPHOMETRICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; REPEATED DRUG DOSE; SMOOTH MUSCLE FIBER; SPLEEN CELL; T CELL DEPLETION; THROMBOCYTE; THROMBOCYTE LEUKOCYTE CONJUGATION;

ANIMALS; ANTIBODIES, MONOCLONAL; AUTOIMMUNITY; ENZYME-LINKED IMMUNOSORBENT ASSAY; GRAFT REJECTION; HEART TRANSPLANTATION; HISTOCOMPATIBILITY TESTING; LEUKOCYTES; LYMPHOCYTE DEPLETION; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICROSCOPY, CONFOCAL; MINOR HISTOCOMPATIBILITY ANTIGENS; RECOMBINANT PROTEINS; T-LYMPHOCYTES; TRANSPLANTATION, HETEROTOPIC; TRANSPLANTATION, HOMOLOGOUS; TRANSPLANTATION, ISOGENEIC; VIMENTIN;

EID: 77954623131     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181dfa694     Document Type: Article

References (40)

1. Taylor DO, Edwards LB, Aurora P, et al. Registry of the International Society for Heart and Lung Transplantation: Twenty-fifth official adult heart transplant report-2008. J Heart Lung Transplant 2008; 27: 943.
2. RahmaniM, Cruz RP, Granville DJ, et al. Allograft vasculopathy versus atherosclerosis. Circ Res 2006; 99: 801.
3. Chapman JR, O'Connell PJ, Nankivell BJ. Chronic renal allograft dysfunction. J Am Soc Nephrol 2005;16:3015.
4. Dunn MJ, Rose ML, Latif N, et al. Demonstration by western blotting of antiheart antibodies before and after cardiac transplantation. Transplantation 1991; 51: 806.
5. Warraich RS, Pomerance A, Stanley A, et al. Cardiac myosin autoanti-bodies and acute rejection after heart transplantation in patients with dilated cardiomyopathy. Transplantation 2000; 69: 1609.
6. Morgun A, Shulzhenko N, Unterkircher CS, et al. Pre-and post-transplant anti-myosin and anti-heat shock protein antibodies and cardiac transplant outcome. J Heart Lung Transplant 2004; 23: 204.
7. Laguens RP, Argel MI, Chambo JG, et al. Anti-skeletal muscle glyco-lipid antibodies in human heart transplantation as markers of acute rejection.Correlation with endomyocardial biopsy. Transplantation 1996; 62: 211.
8. Linke AT, Marchant B, Marsh P, et al. Screening of a HUVEC cDNA library with transplant-associated coronary artery disease sera identifies RPL7 as a candidate autoantigen associated with this disease. Clin Exp Immunol 2001; 126: 173.
9. Lawson C, Holder AL, Stanford RE, et al. Anti-intercellular adhesion molecule-1 antibodies in sera of heart transplant recipients: a role in endothelial cell activation. Transplantation 2005; 80: 264.
10. JurcevicS, Ainsworth ME, PomeranceA, et al. Antivimentin antibodies are an independent predictor of transplant-associated coronary artery disease after cardiac transplantation. Transplantation 2001; 71: 886.
11. Goers TA, Ramachandran S, Aloush A, et al. De novo production of K-alpha1 tubulin-specific antibodies: role in chronic lung allograft rejection. J Immunol 2008; 180: 4487.
12. Fedoseyeva EV, Tam RC, Popov IA, et al. Induction of T cell responses to a self-antigen following allotransplantation. Transplantation 1996; 61: 679.
13. Fedoseyeva EV, Zhang F, Orr PL, et al. De novo autoimmunity to cardiac myosin after heart transplantation and its contribution to the rejection process. J Immunol 1999; 162: 6836.
14. Haque MA, Mizobuchi T, Yasufuku K, et al. Evidence for immune responses to a self-antigen in lung transplantation: Role of type V collagen-specific T cells in the pathogenesis of lung allograft rejection. J Immunol 2002; 169: 1542.
15. Yasufuku K, Heidler KM, O'Donnell PW, et al. Oral tolerance induction by type V collagen downregulates lung allograft rejection. Am J Respir Cell Mol Biol 2001; 25: 26.
16. Yasufuku K, Heidler KM, Woods KA, et al. Prevention of bronchiolitis obliterans in rat lung allografts by type V collagen-induced oral tolerance. Transplantation 2002; 73: 500.
17. Iwata T, Philipovskiy A, Fisher AJ, et al. Anti-type V collagen humoral immunity in lung transplant primary graft dysfunction. J Immunol 2008; 181: 5738.
18. Liu Z, Colovai AI, Tugulea S, et al. Indirect recognition of donor HLA-DR peptides in organ allograft rejection. J Clin Invest 1996; 98: 1150.
19. Azimzadeh AM, Pfeiffer S, Wu GS, et al. Humoral immunity to vimen-tin is associated with cardiac allograft injury in nonhuman primates. Am J Transplant 2005; 5: 2349.
20. Jonker M, Danskine A, Haanstra K, et al. The autoimmune response to vimentin after renal transplantation in nonhuman primates is immu-nosuppression dependent. Transplantation 2005; 80: 385.
21. Mahesh B, Leong HS, McCormack A, et al. Autoantibodies to vimentin cause accelerated rejection of cardiac allografts. Am J Pathol 2007; 170: 1415.
22. Russell PS, Chase CM, Winn HJ, et al. Coronary atherosclerosis in transplanted mouse hearts. II. Importance of humoral immunity.J Immunol 1994; 152: 5135.
23. Russell PS, Chase CM, Colvin RB. Alloantibody-and T cell-mediated immunity in the pathogenesis of transplant arteriosclerosis: Lack of progression to sclerotic lesions in B cell-deficient mice. Transplantation 1997; 64: 1531.
24. Tanaka M. Progression of alloresponse and tissue-specific immunity during graft coronary artery disease. Am J Transplant 2005; 5: 1286.
25. Lidington EA, Rao RM, Marelli-Berg FM, et al. Conditional immortalization of growth factor-responsive cardiac endothelial cells from H-2K(b)-tsA58 mice. Am J Physiol Cell Physiol 2002; 282: C67.
26. Corry RJ, Winn HJ, Russell PS. Primarily vascularized allografts of hearts in mice. The role of H-2D, H-2K, and non-H-2 antigens in rejection. Transplantation 1973; 16: 343.
27. Rahimi S, Qian Z, Layton J, et al. Non-complement-and complement-activating antibodies synergize to cause rejection of cardiac allografts. Am J Transplant 2004; 4: 326.
28. Uehara S, Chase CM, Cornell LD, et al. Chronic cardiac transplant arteriopathy in mice: relationship of alloantibody, C4d deposition and neointimal fibrosis. Am J Transplant 2007; 7: 57.
29. Leong HS, Mahesh B, Day JR, et al. Vimenin autoantibodies induce platelet activation and formation of platelet-leukocyte conjugates via platelet-activating factor. J Leukoc Biol 1-2-2008; 83.
30. Ref Type: Generic. Wang Y, Bai Y, Qin L, et al. Interferon-gamma induces human vascular smooth muscle cell proliferation and intimal expansion by phosphati-dylinositol 3-kinase dependent mammalian target of rapamycin raptor complex 1 activation. Circ Res 2007; 101: 560.
31. Galvani S, Auge N, Calise D, et al. HLA class I antibodies provoke graft arteriosclerosis in human arteries transplanted into SCID/beige mice. Am J Transplant 2009; 9: 2607.
32. Soleimani B, Lechler RI, Hornick PI, et al. Role of alloantibodies in the pathogenesis of graft arteriosclerosis in cardiac transplantation. Am J Transplant 2006; 6: 1781.
33. Win TS, Rehakova S, Negus MC, et al. Donor CD4 T cells contribute to cardiac allograft vasculopathy by providing help for autoantibody production. Circ Heart Fail 2009; 2: 361.
34. Fedoseyeva EV, Kishimoto K, Rolls HK, et al. Modulation of tissue-specific immune response to cardiac myosin can prolong survival of allogeneic heart transplants. J Immunol 2002; 169: 1168.
35. Lamb DJ, El-Sankary W, Ferns GA. Molecular mimicry in atherosclerosis: a role for heat shock proteins in immunisation. Atherosclerosis 2003; 167: 177.
36. Boilard E, Bourgoin SG, Bernatchez C, et al. Identification of an au-toantigen on the surface of apoptotic human T cells as a new protein interacting with inflammatory group IIA phospholipase A2. Blood 2003; 102: 2901.
37. Podor TJ, Singh D, Chindemi P, et al. Vimentin exposed on activated platelets and platelet microparticles localizes vitronectin and plasminogen activator inhibitor complexes on their surface. J Biol Chem 2002; 277: 7529.
38. Moisan E, Girard D. Cell surface expression of intermediate filament proteins vimentin and lamin B1 in human neutrophil spontaneous apoptosis. J Leukoc Biol 2006; 79: 489.
39. Dragun D, Muller DN, Brasen JH, et al. Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection. N Engl J Med 2005; 352: 558.
40. Barber LD, Whitelegg A, Madrigal JA, et al. Detection of vimentin-specific autoreactive CD8+ T cells in cardiac transplant patients 2. Transplantation 2004; 77: 1604.