Guideline-concordant antidepressant use among patients with major depressive disorder

General Hospital Psychiatry

Volumn 32, Issue 4, 2010, Pages 360-367

  Chen, Shih Yin ^a   Hansen, Richard A ^b   Gaynes, Bradley N ^b   Farley, Joel F ^b   Morrissey, Joseph P ^b   Maciejewski, Matthew L ^c,d  

^a Abt Bio Pharma Solutions Inc   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c DURHAM VA MEDICAL CENTER   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Antidepressants; Clinical guideline; Depression; Follow up visits; Provider specialty

Indexed keywords

AMFEBUTAMONE; ANTIDEPRESSANT AGENT; CITALOPRAM; ESCITALOPRAM; FLUOXETINE; MIRTAZAPINE; PAROXETINE; SERTRALINE; VENLAFAXINE;

ADULT; AGE DISTRIBUTION; ARTICLE; CONTROLLED STUDY; DRUG USE; FEMALE; FOLLOW UP; HEALTH INSURANCE; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; PATIENT COMPLIANCE; PRACTICE GUIDELINE; PRESCRIPTION; PSYCHIATRIST; SEX DIFFERENCE; TREATMENT PLANNING; AMBULATORY CARE; CONFIDENCE INTERVAL; DEPRESSIVE DISORDER, MAJOR; MEDICATION COMPLIANCE; MEDICINE; PSYCHIATRY; PSYCHOLOGY; RISK; STATISTICAL MODEL; STATISTICS AND NUMERICAL DATA;

ADULT; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; CONFIDENCE INTERVALS; DEPRESSIVE DISORDER, MAJOR; FEMALE; GUIDELINE ADHERENCE; HUMANS; LOGISTIC MODELS; MALE; MEDICATION ADHERENCE; MEDICINE; ODDS RATIO; OFFICE VISITS; PSYCHIATRY;

EID: 77954610935     PISSN: 01638343     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.genhosppsych.2010.03.007     Document Type: Article

References (43)

1. Kessler R.C., Berglund P., Demler O., Jin R., Koretz D., Merikangas K.R., et al. The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA 2003, 289:3095-3105.
2. Murray C.J., Lopez A.D. Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. Lancet 1997, 349:1498-1504.
3. Sclar D.A., Robison L.M., Skaer T.L. Ethnicity/race and the diagnosis of depression and use of antidepressants by adults in the United States. Int Clin Psychopharmacol 2008, 23:106-109.
4. Practice guideline for the treatment of patients with major depressive disorder 2000, American Psychiatric Association. 2nd ed, 10.1176/appi.books.9780890423363.48690.
5. Depression in primary care: volume 2: treatment of major Depression. Clinical Practice Guideline No. 5 1993, Dept of Health and Human Services, Public Health Service, Agency for Health Care Policy and Research; Depression Guideline Panel, Rockville (MD), Available at: http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=hsarchive&part=A15593. Accessed April 11, 2010.
6. Akincigil A., Bowblis J.R., Levin C., Walkup J., Jan S., Crystal S. Adherence to antidepressant treatment among privately insured patients diagnosed with depression. Med Care 2007, 45:363-369.
7. Charbonneau A., Rosen A.K., Ash A.S., Owen R.R., Kader B., Spiro A., et al. Measuring the quality of depression care in a large integrated health system. Med Care 2003, 41:669-680.
8. Jones L.E., Turvey C., Carney-Doebbeling C. Inadequate follow-up care for depression and its impact on antidepressant treatment duration among veterans with and without diabetes mellitus in the Veterans Health Administration. Gen Hosp Psychiatry 2006, 28:465-474.
9. Olfson M., Marcus S.C., Tedeschi M., Wan G.J. Continuity of antidepressant treatment for adults with depression in the United States. Am J Psychiatry 2006, 163:101-108.
10. Robinson R.L., Long S.R., Chang S., Able S., Baser O., Obenchain R.L., et al. Higher costs and therapeutic factors associated with adherence to NCQA HEDIS antidepressant medication management measures: analysis of administrative claims. J Manag Care Pharm 2006, 12:43-54.
11. Simon G.E., Von Korff M., Rutter C.M., Peterson D.A. Treatment process and outcomes for managed care patients receiving new antidepressant prescriptions from psychiatrists and primary care physicians. Arch Gen Psychiatry 2001, 58:395-401.
12. Young A.S., Klap R., Sherbourne C.D., Wells K.B. The quality of care for depressive and anxiety disorders in the United States. Arch Gen Psychiatry 2001, 58:55-61.
13. Fairman K.A., Drevets W.C., Kreisman J.J., Teitelbaum F. Course of antidepressant treatment drug type, and prescriber's specialty. Psychiatr Serv 1998, 49:1180-1186.
14. Hylan T.R., Crown W.H., Meneades L., Heiligenstein J.H., Melfi C.A., Croghan T.W., et al. SSRI antidepressant drug use patterns in the naturalistic setting: a multivariate analysis. Med Care 1999, 37:AS36-AS44.
15. Weilburg J.B., O'Leary K.M., Meigs J.B., Hennen J., Stafford R.S. Evaluation of the adequacy of outpatient antidepressant treatment. Psychiatr Serv 2003, 54:1233-1239.
16. Bambauer K.Z., Soumerai S.B., Adams A.S., Zhang F., Ross-Degnan D. Provider and patient characteristics associated with antidepressant nonadherence: the impact of provider specialty. J Clin Psychiatry 2007, 68:867-873.
17. Busch S.H., Leslie D., Rosenheck R. Measuring quality of pharmacotherapy for depression in a national health care system. Med Care 2004, 42:532-542.
18. Chen S., Hansen R.A., Farley J.F., Gaynes B.N., Morrissey J.P., Maciejewski M.L. Follow-up visits by provider specialty for patients with major depressive disorder initiating antidepressant treatment. Psychiatr Serv 2010, 61:81-85.
19. Ray W.A. Evaluating medication effects outside of clinical trials: new-user designs. Am J Epidemiol 2003, 158:915-920.
20. Williams J.W., Mulrow C.D., Chiquette E., Noel P.H., Aguilar C., Cornell J. A systematic review of newer pharmacotherapies for depression in adults: evidence report summary. Ann Intern Med 2000, 132:743-756.
21. Reports of suicidality in pediatric patients being treated with antidepressant medications for major depressive disorder (MDD), Vol. 2008, Food and Drug Administration Public Health Advisory, 2003. Available at: Accessed April 11, 2010. http://www.fda.gov/Drugs/DrugSafety/PublicHealthAdvisories/ucm168828.htm.
22. Andrade S.E., Kahler K.H., Frech F., Chan K.A. Methods for evaluation of medication adherence and persistence using automated databases. Pharmacoepidemiol Drug Saf 2006, 15:565-574.
23. Sclar D.A., Robison L.M., Skaer T.L., Legg R.F., Nemec N.L., Galin R.S., et al. Antidepressant pharmacotherapy: economic outcomes in a health maintenance organization. Clin Ther 1994, 16:715-730. [discussion 74].
24. Sclar D.A., Skaer T.L., Chin A., Okamoto M.P., Gill M.A. Utility of a transdermal delivery system for antihypertensive therapy: Part 1. Am J Med 1991, 91:50S-56S.
25. Sikka R., Xia F., Aubert R.E. Estimating medication persistency using administrative claims data. Am J Manag Care 2005, 11:449-457.
26. Sheehan D.V., Eaddy M.T., Shah M.B., Mauch R.P. Differences in total medical costs across the SSRIs for the treatment of depression and anxiety. Am J Manag Care 2005, 11:S354-S361.
27. Thompson D., Buesching D., Gregor K.J., Oster G. Patterns of antidepressant use and their relation to cost of care. Am J Manag Care 1996, 1239-1246.
28. Cantrell C.R., Eaddy M.T., Shah M.B., Regan T.S., Sokol M.C. Methods for evaluating patient adherence to antidepressant therapy: a real-world comparison of adherence and economic outcomes. Med Care 2006, 44:300-303.
29. Stein M.B., Cantrell C.R., Sokol M.C., Eaddy M.T., Shah M.B. Antidepressant adherence and medical resource use among managed care patients with anxiety disorders. Psychiatr Serv 2006, 57:673-680.
30. HEDIS 2006. Healthcare Effectiveness Data & Information Set. Vol. 2, Technical Specifications 2005, National Committee for Quality Assurance (NCQA), Washington (DC).
31. Chen, X., Ender, P., Mitchell, M. and Wells, C. (2003). Regression with Stata. Available at Accessed on August 5, 2008. http://www.ats.ucla.edu/stat/stata/webbooks/reg/default.htm.
32. Clark D.O., Von Korff M., Saunders K., Baluch W.M., Simon G.E. A chronic disease score with empirically derived weights. Medical Care 1995, 33:783-795.
33. Parsons L.S. Reducing bias in a propensity score matched pair sample using greedy matching techniques in SAS Users Group International (SUGI) Conference 29, Montreal, Canada 2001, 214-226. Available at: http://www2.sas.com/proceedings/sugi26/p214-26.pdf.
34. Ai C., Norton E.C. Interaction terms in logit and probit models. Economics letters 2003, 80:123-129.
35. Norton E.C., Wang H., Ai C. Computing interaction effects and standard errors in logit and probit models. Stata J 2004, 4:154-167.
36. Wells K.B., Burnam M.A., Camp P. Severity of depression in prepaid and fee-for-service general medical and mental health specialty practices. Med Care 1995, 33:350-364.
37. Trivedi M.H., Lin E.H., Katon W.J. Consensus recommendations for improving adherence, self-management, and outcomes in patients with depression. CNS Spectr 2007, 12:1-27.
38. Gensichen J., Beyer M., Muth C., Gerlach F.M., Von Korff M., Ormel J. Case management to improve major depression in primary health care: a systematic review. Psychol Med 2006, 36:7-14.
39. Vergouwen A.C., Bakker A., Katon W.J., Verheij T.J., Koerselman F. Improving adherence to antidepressants: a systematic review of interventions. J Clin Psychiatry 2003, 64:1415-1420.
40. Gilbody S., Whitty P., Grimshaw J., Thomas R. Educational and organizational interventions to improve the management of depression in primary care: a systematic review. JAMA 2003, 289:3145-3151.
41. Lin E.H., Von Korff M., Katon W., Bush T., Simon G.E., Walker E., et al. The role of the primary care physician in patients' adherence to antidepressant therapy. Med Care 1995, 33:67-74.
42. Williams J.W., Gerrity M., Holsinger T., Dobscha S., Gaynes B., Dietrich A. Systematic review of multifaceted interventions to improve depression care. Gen Hosp Psychiatry 2007, 29:91-116.
43. Gaynes B.N., Rush A.J., Trivedi M.H., Wisniewski S.R., Balasubramani G.K., McGrath P.J., et al. Primary versus specialty care outcomes for depressed outpatients managed with measurement-based care: results from STAR*D. J Gen Intern Med 2008, 23:551-560.