Visualisation of tumour regression after local chemotherapy with magnetic nanoparticles - A pilot study

Anticancer Research

Volumn 30, Issue 5, 2010, Pages 1553-1557

  Lyer, Stefan ^a   Tietze, Rainer ^a   Jurgons, Roland ^a   Struffert, Tobias ^a   Engelhorn, Tobias ^a   Schreiber, Eveline ^a   Dörfler, Arnd ^a   Alexiou, Christoph ^a  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

Angiography; Computed tomography; Flat panel CT; Local chemotherapy; Magnetic drug targeting; Tumour vascularisation

Indexed keywords

MAGNETIC NANOPARTICLE; MITOXANTRONE;

ANGIOGRAPHY; CANCER CHEMOTHERAPY; COMPUTER ASSISTED TOMOGRAPHY; CONFERENCE PAPER; DRUG DELIVERY SYSTEM; NONHUMAN; PRIORITY JOURNAL; RABBIT; TUMOR; TUMOR REGRESSION; TUMOR VASCULARIZATION;

ANGIOGRAPHY; ANIMALS; ANTINEOPLASTIC AGENTS; DISEASE MODELS, ANIMAL; DRUG CARRIERS; FEMALE; FEMORAL ARTERY; FERRIC COMPOUNDS; MAGNETICS; NANOPARTICLES; NANOTECHNOLOGY; NEOPLASM TRANSPLANTATION; NEOPLASMS; RABBITS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 77954603681     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (24)

1. Deutsche Krebsgeselłschaft e.V. (German Cancer Society), Berlin, Germany, Available at www.krebsgeselischaft.de/, 2006.
2. Robert Koch-Institut, Berlin, Germany, Available at www.rki.de, 2006.
3. Groner B, Hartmann C and Wels W: Therapeutic antibodies. Curr Mol Med 4: 539-547, 2004.
4. Mellstedt H: Monoclonal antibodies in human cancer. Drugs Today (Barc) 39(Suppl C): 1-16, 2003.
5. Weiner LM: Fully human therapeutic monoclonal antibodies. J Immunother 29: 1-9, 2006.
6. de Gramont A and Van Cutsem E: Investigating the potential of bevacizumab in other indications: metastatic renal cell, non-small cell lung, pancreatic and breast cancer. Oncology 69(Suppl 3): 46-56, 2005.
7. Socinski MA: Bevacizumab as first-line treatment for advanced non-small cell lung cancer. Drugs Today (Barc) 44: 293-301, 2008. (Pubitemid 351897262)
8. Stinchcombe TE and Socinski MA: Bevacizumab in the treatment of non-small cell lung cancer. Oncogene 26: 3691-3698, 2007.
9. Loos M, Kleeff J, Friess H and Buchler MW: Surgical treatment of pancreatic cancer. Ann NY Acad Sci 1138: 169-180, 2008.
10. Nakeeb A, Lillemoe KD and Grosfeld JL: Surgical techniques for pancreatic cancer. Minerva Chir 59: 151-163, 2004.
11. Perez EA: Cardiac toxicity of ErbB2-targeted therapies: what do we know? Clin Breast Cancer 8(Suppl 3): S114-120, 2008.
12. Carney PH and Ollom CL: Infusion reactions triggered by monoclonal antibodies treating solid tumours. J Infus Nurs 31: 74-83, 2008.
13. Wolf S et al: Chemotherapy-induced peripheral neuropathy: prevention and treatment strategies. Eur J Cancer 44: 1507-1515, 2008.
14. Guillot B, Bessis D and Dereure O: Mucocutaneous side effects of antineoplastic chemotherapy. Expert Opin Drug Saf 3: 579-587, 2004.
15. Reck M et al: Phase II study of oral vinorelbine in combination with carboplatin followed by consolidation therapy with oral vinorelbine as single-agent in unresectable localized or metastatic non-small cell lung carcinoma. Lung Cancer, 2008.
16. Pectasides D et al: Weekly chemotherapy with carboplatin, docetaxel and irinotecan in advanced non-small-cell-lung cancer: a phase II study. Eur J Cancer 38: 1194-1200, 2002. (Pubitemid 34603479)
17. Alexiou C et al: Locoregional cancer treatment with magnetic drug targeting. Cancer Res 60: 6641-6648, 2000.
18. Dobson J: Magnetic nanoparticles for drug delivery. Drug Dev Res 67: 55-60, 2006.
19. Alexiou C et al: A high field gradient magnet for magnetic drug targeting. IEEE Trans Appl Superconduct 16: 1527-1530, 2006. (Pubitemid 44150135)
20. McBain SC, Yiu HH and Dobson J: Magnetic nanoparticles for gene and drug delivery. Int J Nanomedicine 3: 169-180, 2008. (Pubitemid 352037850)
21. Alexiou C et al: Magnetic drug targeting - biodistribution of the magnetic carrier and the chemotherapeutic agent mitoxantrone after locoregional cancer treatment. J Drug Target 11: 139-149, 2003. (Pubitemid 37236327)
22. Kalender WA and Kyriakou Y: Flat-detector computed tomography (FD-CT). Eur Radiol 17: 2767-2779, 2007.
23. Engelhorn T et al: Flat panel detector angiographic CT in the management of Aneurysmal rupture during coil embolization. Am J Neuroradiol 29: 1581-1584, 2008.
24. Alexiou C et al: Targeting cancer cells: magnetic nanoparticles as drug carriers. Eur Biophys J 35: 446-450, 2006.