Early phase resolution of mucosal eosinophilic inflammation in allergic rhinitis

Respiratory Research

Volumn 11, Issue , 2010, Pages

  Uller, Lena ^a   Emanuelsson, Cecilia A ^b   Andersson, Morgan ^b   Erjefält, Jonas S ^a   Greiff, Lennart ^b   Persson, Carl G ^b  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; BUDESONIDE; EOTAXIN; LORATADINE; PLACEBO; RANTES; ANTIALLERGIC AGENT; CCL11 PROTEIN, HUMAN; CCL5 PROTEIN, HUMAN; PLANT ANTIGEN;

ADULT; ALLERGIC RHINITIS; APOPTOSIS; ARTICLE; BIRCH; CELL PROLIFERATION; CLINICAL ARTICLE; DOUBLE BLIND PROCEDURE; EOSINOPHILIA; EPITHELIUM CELL; FEMALE; GRASS; HISTOCHEMISTRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; MALE; NASAL BIOPSY; POLLEN; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; SYMPTOM; TREATMENT DURATION; BIOPSY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; CYTOLOGY; DRUG EFFECT; HAY FEVER; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; INFLAMMATION; INTRANASAL DRUG ADMINISTRATION; METABOLISM; NICK END LABELING; NOSE MUCOSA; NOSE MUCUS; PATHOLOGY; PLACEBO EFFECT; POACEAE; TIME; TREATMENT OUTCOME;

ADMINISTRATION, INTRANASAL; ADULT; ANTI-ALLERGIC AGENTS; ANTIGENS, PLANT; APOPTOSIS; BETULA; BIOPSY; BUDESONIDE; CELL PROLIFERATION; CHEMOKINE CCL11; CHEMOKINE CCL5; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; EOSINOPHILIA; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INFLAMMATION; MALE; NASAL LAVAGE FLUID; NASAL MUCOSA; PLACEBO EFFECT; POACEAE; POLLEN; RHINITIS, ALLERGIC, SEASONAL; TIME FACTORS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 77954589735     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-11-54     Document Type: Article

References (29)

1. Barnes ML, Menzies D, Fardon TC, Burns P, Wilson AM, Lipworth BJ. Combined mediator blockade or topical steroid for treating the unified allergic airway. Allergy 2007, 62(1):73-80. 10.1111/j.1398-9995.2006.01263.x, 17156345.
2. Haslett C. Granulocyte apoptosis and its role in the resolution and control of lung inflammation. Am J Respir Crit Care Med 1999, 160(5 Pt 2):S5-11.
3. Vignola AM, Chiappara G, Gagliardo R, Gjomarkaj M, Merendino A, Siena L, Bousquet J, Bonsignore G. Apoptosis and airway inflammation in asthma. Apoptosis 2000, 5(5):473-485. 10.1023/A:1009661406440, 11256890.
4. Druilhe A, Letuve S, Pretolani M. Glucocorticoid-induced apoptosis in human eosinophils: mechanisms of action. Apoptosis 2003, 8(5):481-495. 10.1023/A:1025590308147, 12975579.
5. Walsh GM. Defective apoptotic cell clearance in asthma and COPD--a new drug target for statins?. Trends Pharmacol Sci 2008, 29(1):6-11. 10.1016/j.tips.2007.11.002, 18054798.
6. Ikeda RK, Nayar J, Cho JY, Miller M, Rodriguez M, Raz E, Broide DH. Resolution of airway inflammation following ovalbumin inhalation: comparison of ISS DNA and corticosteroids. Am J Respir Cell Mol Biol 2003, 28(6):655-663. 10.1165/rcmb.4853, 12760963.
7. Uller L, Persson CG, Kallstrom L, Erjefalt JS. Lung tissue eosinophils may be cleared through luminal entry rather than apoptosis: effects of steroid treatment. Am J Respir Crit Care Med 2001, 164(10 Pt 1):1948-1956.
8. Uller L, Lloyd CM, Rydell-Tormanen K, Persson CG, Erjefalt JS. Effects of steroid treatment on lung CC chemokines, apoptosis and transepithelial cell clearance during development and resolution of allergic airway inflammation. Clin Exp Allergy 2006, 36(1):111-121. 10.1111/j.1365-2222.2006.02396.x, 16393273.
9. Uller L, Persson CG, Erjefalt JS. Resolution of airway disease: removal of inflammatory cells through apoptosis, egression or both?. Trends Pharmacol Sci 2006, 27(9):461-466. 10.1016/j.tips.2006.07.006, 16876880.
10. Erjefalt JS, Uller L, Malm-Erjefalt M, Persson CG. Rapid and efficient clearance of airway tissue granulocytes through transepithelial migration. Thorax 2004, 59(2):136-143. 10.1136/thorax.2003.004218, 1746951, 14760154.
11. Linden M, Svensson C, Andersson E, Andersson M, Greiff L, Persson CG. Immediate effect of topical budesonide on allergen challenge-induced nasal mucosal fluid levels of granulocyte-macrophage colony-stimulating factor and interleukin-5. Am J Respir Crit Care Med 2000, 162(5):1705-1708.
12. Southam DS, Ellis R, Wattie J, Young S, Inman MD. Budesonide prevents but does not reverse sustained airway hyperresponsiveness in mice. Eur Respir J 2008, 32(4):970-978. 10.1183/09031936.00125307, 18508821.
13. Holgate ST, Bodey KS, Janezic A, Frew AJ, Kaplan AP, Teran LM. Release of RANTES, MIP-1 alpha, and MCP-1 into asthmatic airways following endobronchial allergen challenge. Am J Respir Crit Care Med 1997, 156(5):1377-1383.
14. Ying S, Meng Q, Zeibecoglou K, Robinson DS, Macfarlane A, Humbert M, Kay AB. Eosinophil chemotactic chemokines (eotaxin, eotaxin-2, RANTES, monocyte chemoattractant protein-3 (MCP-3), and MCP-4), and C-C chemokine receptor 3 expression in bronchial biopsies from atopic and nonatopic (Intrinsic) asthmatics. J Immunol 1999, 163(11):6321-6329.
15. Rajakulasingam K, Hamid Q, O'Brien F, Shotman E, Jose PJ, Williams TJ, Jacobson M, Barkans J, Durham SR. RANTES in human allergen-induced rhinitis: cellular source and relation to tissue eosinophilia. Am J Respir Crit Care Med 1997, 155(2):696-703.
16. Zhu J, Qiu YS, Majumdar S, Gamble E, Matin D, Turato G, Fabbri LM, Barnes N, Saetta M, Jeffery PK. Exacerbations of Bronchitis: bronchial eosinophilia and gene expression for interleukin-4, interleukin-5, and eosinophil chemoattractants. Am J Respir Crit Care Med 2001, 164(1):109-116.
17. Castro M, Bloch SR, Jenkerson MV, DeMartino S, Hamilos DL, Cochran RB, Zhang XE, Wang H, Bradley JP, Schechtman KB, et al. Asthma exacerbations after glucocorticoid withdrawal reflects T cell recruitment to the airway. Am J Respir Crit Care Med 2004, 169(7):842-849. 10.1164/rccm.200208-960OC, 14726420.
18. Persson CG, Svensson C, Greiff L, Anderson M, Wollmer P, Alkner U, Erjefalt I. The use of the nose to study the inflammatory response of the respiratory tract. Thorax 1992, 47(12):993-1000. 10.1136/thx.47.12.993, 1021088, 1494783.
19. Ahlstrom Emanuelsson C, Andersson M, Persson CG, Thorsson L, Greiff L. Effects of topical formoterol alone and in combination with budesonide in a pollen season model of allergic rhinitis. Respiratory medicine 2007, 101(6):1106-1112. 10.1016/j.rmed.2006.11.017, 17215115.
20. Ahlstrom-Emanuelsson C, Persson CG, Svensson C, Andersson M, Hosszu Z, Akerlund A, Greiff L. Establishing a model of seasonal allergic rhinitis and demonstrating dose-response to a topical glucocorticosteroid. Ann Allergy Asthma Immunol 2002, 89(2):159-165. 10.1016/S1081-1206(10)61932-1, 12197572.
21. Greiff L, Pipkorn U, Alkner U, Persson CG. The 'nasal pool' device applies controlled concentrations of solutes on human nasal airway mucosa and samples its surface exudations/secretions. Clin Exp Allergy 1990, 20(3):253-259. 10.1111/j.1365-2222.1990.tb02680.x, 2364306.
22. Uller L, Andersson M, Greiff L, Persson CG, Erjefalt JS. Occurrence of apoptosis, secondary necrosis, and cytolysis in eosinophilic nasal polyps. Am J Respir Crit Care Med 2004, 170(7):742-747. 10.1164/rccm.200402-240OC, 15229095.
23. Ivarsson K, Myllymaki L, Jansner K, Bruun A, Stenram U, Tranberg KG. Heat shock protein 70 (HSP70) after laser thermotherapy of an adenocarcinoma transplanted into rat liver. Anticancer Research 2003, 23(5A):3703-3712.
24. Persson CG, Erjefalt JS, Erjefalt I, Korsgren MC, Nilsson MC, Sundler F. Epithelial shedding--restitution as a causative process in airway inflammation. Clin Exp Allergy 1996, 26(7):746-755. 10.1111/j.1365-2222.1996.tb00604.x, 8842547.
25. Uller L, Rydell-Tormanen K, Persson CG, Erjefalt JS. Anti-Fas mAb-induced apoptosis and cytolysis of airway tissue eosinophils aggravates rather than resolves established inflammation. Respir Res 2005, 6:90. 10.1186/1465-9921-6-90, 1187926, 16086832.
26. Lloyd C. Chemokines in allergic lung inflammation. Immunology 2002, 105(2):144-154. 10.1046/j.1365-2567.2002.01344.x, 1782646, 11872089.
27. Taguchi M, Sampath D, Koga T, Castro M, Look DC, Nakajima S, Holtzman MJ. Patterns for RANTES secretion and intercellular adhesion molecule 1 expression mediate transepithelial T cell traffic based on analyses in vitro and in vivo. J Exp Med 1998, 187(12):1927-1940. 10.1084/jem.187.12.1927, 2212358, 9625753.
28. Erjefalt JS, Erjefalt I, Sundler F, Persson CG. Effects of topical budesonide on epithelial restitution in vivo in guinea pig trachea. Thorax 1995, 50(7):785-792. 10.1136/thx.50.7.785, 474655, 7570417.
29. Zhang N, Truong-Tran QA, Tancowny B, Harris KE, Schleimer RP. Glucocorticoids enhance or spare innate immunity: effects in airway epithelium are mediated by CCAAT/enhancer binding proteins. J Immunol 2007, 179(1):578-589. 2121188, 17579079.