Bias and trials stopped early for benefit [2]

JAMA

Volumn 304, Issue 2, 2010, Pages 157-

  Goodman, Steven ^a   Berry, Donald ^b   Wittes, Janet ^c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c University of Iowa   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CENTRAL TENDENCY BIAS; CLINICAL RESEARCH; HUMAN; LETTER; PRIORITY JOURNAL; STUDY DESIGN; EPIDEMIOLOGY; ETHICS; NOTE; RANDOMIZED CONTROLLED TRIAL; STATISTICAL ANALYSIS; STATISTICS; TREATMENT OUTCOME;

BIAS (EPIDEMIOLOGY); DATA INTERPRETATION, STATISTICAL; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TREATMENT OUTCOME;

EID: 77954586754     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2010.931     Document Type: Letter

References (5)

1. Bassler D, Briel M, Montori VM, et al; STOPIT-2 Study Group. Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis. JAMA. 2010;303(12):1180-1187.
2. Goodman SN. Stopping at nothing? some dilemmas of data monitoring in clinical trials. Ann Intern Med. 2007;146(12):882-887.
3. Freidlin B, Korn EL. Stopping clinical trials early for benefit: impact on estimation. Clin Trials. 2009;6(2):119-125.
4. Emerson SS, Fleming TR. Parameter estimation following sequential hypothesis testing. Biometrika. 1990;77:875-892.
5. Goodman SN. Systematic reviews are not biased by results from trials stopped early for benefit. J Clin Epidemiol. 2008;61(1):95-96.