A transcriptome-wide approach reveals the key contribution of NFI-A in promoting erythroid differentiation of human CD34+ progenitors and CML cells

Leukemia

Volumn 24, Issue 6, 2010, Pages 1220-1223

  Starnes, L M ^a,b   Sorrentino, A ^c   Ferracin, M ^d   Negrini, M ^d   Pelosi, E ^c   Nervi, C ^a,b   Peschle, C ^e  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b San Raffaele Biomedical Park Foundation   (Italy)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^d UNIVERSITY OF FERRARA   (Italy)

^e IRCCS MULTIMEDICA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYTARABINE; FLT3 LIGAND; GROWTH FACTOR; GROWTH FACTOR RECEPTOR; HEMOGLOBIN CHAIN; INTERLEUKIN 3; JANUS KINASE 2; KRUPPEL LIKE FACTOR 2; LENTIVIRUS VECTOR; MESSENGER RNA; NUCLEAR FACTOR I; NUCLEAR FACTOR I A; PROTEIN KINASE B BETA; RHESUS ANTIGEN; TRANSCRIPTION FACTOR JUNB; TRANSCRIPTOME; UNCLASSIFIED DRUG; UVOMORULIN; CD34 ANTIGEN; NFIA PROTEIN, HUMAN; TUMOR MARKER;

BLAST CELL CRISIS; CD34 SELECTION; CELL DIFFERENTIATION; CELL STRAIN K 562; CHROMATIN IMMUNOPRECIPITATION; CHRONIC MYELOID LEUKEMIA; CLUSTER ANALYSIS; CONTROLLED STUDY; DIFFERENTIATION; DOWN REGULATION; ERYTHROID CELL; GENE DOSAGE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE MUTATION; GENETIC ASSOCIATION; GENETIC TRANSDUCTION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; LETTER; LEUKEMIA CELL LINE; MICROARRAY ANALYSIS; MOLECULAR PROBE; MYELOPOIESIS; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; RNA HYBRIDIZATION; SIGNAL TRANSDUCTION; CYTOLOGY; DNA MICROARRAY; ERYTHROID PRECURSOR CELL; GENETICS; METABOLISM; PATHOLOGY;

ANTIGENS, CD34; CELL DIFFERENTIATION; ERYTHROID PRECURSOR CELLS; GENE EXPRESSION PROFILING; HEMATOPOIETIC STEM CELLS; HUMANS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; NFI TRANSCRIPTION FACTORS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 77954584213     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2010.78     Document Type: Letter

References (8)

1. Gronostajski RM. Roles of the NFI/CTF gene family in transcription and development. Gene 2000; 249: 31-45. (Pubitemid 30265485)
2. Starnes LM, Sorrentino A, Pelosi E, Ballarino M, Morsilli O, Biffoni M et al. NFI-A directs the fate of hematopoietic progenitors to the erythroid or granulocytic lineage and controls beta-globin and G-CSF receptor expression. Blood 2009; 114: 1753-1763.
3. Fazi F, Rosa A, Fatica A, Gelmetti V, De Marchis ML, Nervi C et al. A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis. Cell 2005; 123: 819-831. (Pubitemid 41721029)
4. Rosa A, Ballarino M, Sorrentino A, Sthandier O, De Angelis FG, Marchioni M et al. The interplay between the master transcription factor PU.1 and miR-424 regulates human monocyte/macrophage differentiation. Proc Natl Acad Sci USA 2007; 104: 19849-19854.
5. Bernard F, Gelsi-Boyer V, Murati A, Giraudier S, Trouplin V, Adéläde J et al. Alterations of NFIA in chronic malignant myeloid diseases. Leukemia 2009; 23: 583-585.
6. Komor M, Gü ller S, Baldus CD, de Vos S, Hoelzer D, Ottmann OG et al. Transcriptional profiling of human hematopoiesis during in vitro lineage-specific differentiation. Stem Cells 2005; 23: 1154-1169. (Pubitemid 41377731)
7. Macaulay IC, Tijssen MR, Thijssen-Timmer DC, Gusnanto A, Steward M, Burns P et al. Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. Blood 2007; 109: 3260-3299.
8. Cui K, Zang C, Roh TY, Schones DE, Childs RW, Peng W et al. Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation. Cell Stem Cell 2009; 4: 80-93.