Insights into schizophrenia using positron emission tomography: Building the evidence and refining the focus

British Journal of Psychiatry

Volumn 197, Issue 1, 2010, Pages 3-4

  Vyas, Nora S ^a,b   Patel, Neva H ^b   Nijran, Kuldip S ^b   Al Nahhas, Adil ^b   Puri, Basant K ^c  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

^c HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR;

COGNITION; COGNITIVE DEFECT; COMPUTER ASSISTED TOMOGRAPHY; CORPUS STRIATUM; DOPAMINERGIC ACTIVITY; ENVIRONMENTAL FACTOR; GENETIC ANALYSIS; HEREDITY; HUMAN; NEUROCHEMISTRY; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; REVIEW; SCHIZOPHRENIA;

DOPAMINE; EVIDENCE-BASED MEDICINE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; POSITRON-EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; SCHIZOPHRENIA;

EID: 77954583529     PISSN: 00071250     EISSN: 14721465     Source Type: Journal    
DOI: 10.1192/bjp.bp.109.073882     Document Type: Review

References (10)

1. Howes OD, Kapur S. The dopamine hypothesis of schizophrenia: version III the final common pathway. Schizophr Bull 2009; 35: 549-62.
2. McGowan S, Lawrence AD, Sales T, Quested D, Grasby P. Presynaptic dopaminergic dysfunction in schizophrenia: a positron emission tomographic [18F]fluorodopa study. Arch Gen Psychiatry 2004; 61: 134-42. (Pubitemid 38146547)
3. Kumakura Y, Cumming P, Vernaleken I, Buchholz H-G, Siessmeier T, Heinz A, et al. Elevated [18F] fluorodopamine turnover in brain of patients with schizophrenia: an [18F] fluorodopa/positron emission tomography study. J Neurosci 2007; 27: 8080-7.
4. Kestler LP, Walker E, Vega EM. Dopamine receptors in the brains of schizophrenia patients: a meta-analysis of the findings. Behav Pharmacol 2001; 12: 355-71. (Pubitemid 32983509)
5. Buchsbaum MS, Christian BT, Lehrer DS, Narayanan TK, Shi B, Mantil J, et al. D2/D3 dopamine receptor binding with [F-18]fallypride in thalamus and cortex of patients with schizophrenia. Schizophr Res 2006; 85: 232-44.
6. Patel NH, Vyas NS, Puri BK, Nijran KS, Al-Nahhas A. Positron emission tomography imaging in schizophrenia: a new perspective. J Nucl Med 2010; 51: 511-20.
7. Okubo Y, Suhara T, Suzuki K, Kobayashi K, Inoue O, Terasaki O, et al. Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET. Nature 1997; 385: 634-6.
8. Abi-Dargham A, Mawlawi O, Lombardo I, Gil R, Martinez D, Huang Y, et al. Prefrontal dopamine D1 receptor and working memory in schizophrenia. J Neurosci 2002; 22: 3708-19.
9. Karlsson P, Farde L, Halldin C, Sedwell G. PET study of D(1) dopamine receptor binding in neuroleptic-naïve patients with schizophrenia. Am J Psychiatry 2002; 159: 761-7.
10. International Schizophrenia Consortium. Rare chromosomal deletions and duplication increase risk of schizophrenia. Nature 2008; 455: 237-41.