Nanoparticle transport in a realistic model of the tracheobronchial region

International Journal for Numerical Methods in Biomedical Engineering

Volumn 26, Issue 7, 2010, Pages 904-914

  Comerford, A ^a   Bauer, G ^a   Wall, W A ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Computational mass transport; Lung; Mass transfer; Nanoparticles

Indexed keywords

AIRFLOW PATTERNS; COMPUTATIONAL MASS TRANSPORT; EULER-EULER APPROACH; GEOMETRIC EFFECTS; HEALTH CONSEQUENCES; HUMAN LUNG; HUMAN TRACHEOBRONCHIAL REGION; LUNG; MASS TRANSPORT; MODEL-BASED; NONUNIFORMITY; REALISTIC GEOMETRY; REALISTIC MODEL; SPATIAL VARIATIONS; SURROUNDING ENVIRONMENT; TARGETED DRUG DELIVERY; TIME-DEPENDENT EFFECTS; TIME-DEPENDENT TRANSPORT; TOXIC POLLUTANTS; TRACHEOBRONCHIAL REGION;

BIOLOGICAL ORGANS; DRUG DELIVERY; FLOW PATTERNS; MASS TRANSFER;

NANOPARTICLES;

EID: 77954581713     PISSN: 20407939     EISSN: 20407947     Source Type: Journal    
DOI: 10.1002/cnm.1390     Document Type: Article

References (25)

1. Pulliam BL, Sung JC, Edwards DA. Nanoparticles for drug delivery to the lungs. Trends in Biotechnology 2007; 25:563-570.
2. Oberdörster G. Pulmonary effects of inhaled ultrafine particles. International Archives of Occupational and Environmental Health 2001; 74:1-8.
3. Byrne JD, Baugh JA. The significance of nanoparticles in particle-induced pulmonary fibrosis. McGill Journal of Medicine 2008; 11:4350.
4. Oberdörster G, Oberdörster E, Oberdörster J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environmental Health Perspectives 2005; 113:1-8.
5. Donaldson K, Stone V, Gilmour PS, Brown DM, MacNee W. Ultrafine particles: mechanisms of lung injury. Philosophical Transactions: Mathematical, Physical and Engineering Sciences 2000; 358:2741-2749.
6. Cheng YS, Smith SM, Yeh HC. Deposition of ultrafine particles in human tracheobronchial airways. Annals of Occupational Hygiene 1997; 41:714-718.
7. Cohen BS, Asgharian B. Deposition of ultrafine particles in the upper airways: An empirical analysis. Journal of Aerosol Science 1990; 21:789-797.
8. Smith SM, Cheng YS, Yeh HC. Deposition of ultrafine particles in human tracheobronchial airways of adults and children. Aerosol Science and Technology 2001; 35:697-709.
9. Kim CS, Jaques PA. Respiratory dose of inhaled ultrafine particles in healthy adults. Philosophical Transactions of the Royal Society of London A 2000; 358:2693-2705.
10. Shi H, Kleinstreuer C, Zhang Z, Kim CS. Nanoparticle transport and deposition in bifurcating tubes with different inlet conditions. Physics of Fluids 2004; 16:2199-2213.
11. Zhang Z, Kleinstreuer C, Kim CS. Airflow and nanoparticle deposition in a 16-generation tracheobronchial airway model. Annals of Biomedical Engineering 2008; 36(12):2095-2110.
12. Wall WA, Rabczuk T. Fluid structure interaction in lower airways of ct-based lung geometries. International Journal for Numerical Methods in Fluids 2008; 57:653-675.
13. Kleinstreuer C, Zhang Z, Donohue JF. Targeted drug-aerosol delivery in the human respiratory system. Annual Review of Biomedical Engineering 2008; 10:195-220.
14. Shi H, Kleinstreuer C, Zhang Z. Laminar airflow and nanoparticle or vapor deposition in a human nasal cavity model. Journal of Biomechanical Engineering 2006; 128(5):697-706.
15. Xi J, Longest PW. Effects of oral airway geometry characteristics on the diffusional deposition of inhaled nanoparticles. Journal of Biomechanical Engineering 2008; 130:011008.
16. Xi J, Longest PW, Martonen TB. Effects of the laryngeal jet on nano- and microparticle transport and deposition in an approximate model of the upper tracheobronchial airways. Journal of Applied Physiology 2008; 104:1761-1777.
17. Zhang Z, Kleinstreuer C. Airflow structures and nano-particle deposition in a human upper airway model. Journal of Computational Physics 2004; 198:178-210.
18. Comerford A, Förster C, Wall WA. Structured tree impedance outflow boundary conditions for 3D lung simulations. Journal of Biomechanical Engineering 2010; accepted.
19. Förster C, Wall WA, Ramm E. On the geometric conservation law in transient flow calculations on deforming domains. International Journal for Numerical Methods in Fluids 2006; 50:1369-1379.
20. Gresho PM, Lee RL, Sani RL, Maslanik MK, Eaton BE. The consistent Galerkin FEM for computing derived boundary quantities in thermal and or fluids problems. International Journal for Numerical Methods in Fluids 1987; 7:371-394.
21. Baláházy I, Hofmann W, Heistracher T. Computation of local enhancement factors for the quantification of particle deposition patterns in airway bifurcations. Journal of Aerosol Science 1999; 30:185-203.
22. Kleinstreuer C, Zhang Z. An adjustable triple-bifurcation unit model for air-particle flow simulations in human tracheobronchial airways. Journal of Biomechanical Engineering 2009; 131:021007.
23. Tawhai MH, Pullan AH, Hunter PJ. Generation of an anatomically based three-dimensional model of the conducting airways. Annals of Biomedical Engineering 2000; 28:793-802.
24. Wall WA, Wiechert L, Comerford A, Rausch S. Towards a comprehensive computational model for the respiratory system. International Journal for Numerical Methods in Biomedical Engineering 2009; DOI: 10.1002/cnm.1378.
25. Küttler U, Gee M, Förster C, Comerford A, Wall WA. Coupling strategies for biomedical fluid-structure interaction problems. International Journal for Numerical Methods in Biomedical Engineering 2009; 26(3-4):305-321. DOI: 10.1002/cnm.1281.