Changes of bladder activity and connexin 43-derived gap junctions after partial bladder-outlet obstruction in rats

International Urology and Nephrology

Volumn 41, Issue 4, 2009, Pages 815-821

  Miyazato, Minoru ^a   Sugaya, Kimio ^a   Nishijima, Saori ^a   Kadekawa, Katsumi ^a   MacHida, Noriko ^a   Oshiro, Yoshinori ^a   Saito, Seiichi ^a  

^a UNIVERSITY OF THE RYUKYUS   (Japan)

Author keywords

Bladder outlet obstruction; Connexin; Gap junction; Isovolumetric cystometry; Smooth muscle

Indexed keywords

CONNEXIN 43; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER CONTRACTION; BLADDER MUSCLE; BLADDER NECK STENOSIS; CELL COMMUNICATION; CONTROLLED STUDY; FEMALE; GAP JUNCTION; HISTOPATHOLOGY; MICTURITION REFLEX; NONHUMAN; OVERACTIVE BLADDER; PROTEIN EXPRESSION; RAT;

ANIMALS; CONNEXIN 43; DISEASE MODELS, ANIMAL; FEMALE; GAP JUNCTIONS; IMMUNOHISTOCHEMISTRY; MUSCLE CONTRACTION; MUSCLE, SMOOTH; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE VALUES; RNA, MESSENGER; URINARY BLADDER NECK OBSTRUCTION; URINARY RETENTION; URINATION;

EID: 77954564765     PISSN: 03011623     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11255-008-9516-7     Document Type: Article

References (15)

1. Uvelius B, Persson L, Mattiasson A (1984) Smooth muscle cell hypertrophy and hyperplasia in the rat detrusor after short-time infravesical outflow obstruction. J Urol 131: 173-176
2. Saito M, Longhurst PA, Tammela TL et al (1993) Effects of partial outlet obstruction of the rat urinary bladder on micturition characteristics, DNA synthesis and the contractile response to field stimulation and pharmacological agents. J Urol 150:1045-1051
3. Bruzzone R, White TW, Paul DL (1996) Connections with connexins: the molecular basis of direct intercellular signaling. Eur J Biochem 238:1-27. doi:10.1111/j.1432-1033. 1996.0001q.x
4. Christ GJ, Day NS, Day M et al (2003) Increased conn-exin43-mediated intercellular communication in a rat model of detrusor overactivity in vivo. Am J Physiol Regul Integr Comp Physiol 284:R1241-R1248
5. Haefliger JA, Tissieres P, Tawadros T et al (2002) Con-nexins 43 and 26 are differentially increased after rat bladder-outlet obstruction. Exp Cell Res 274:216-225. doi: 10.1006/excr.2001.5465
6. Neuhaus J, Weimann A, Stolzenburg JU et al (2002) Smooth muscle cells from human urinary bladder express connexin 43 in vivo and in vitro. World J Urol 20:250-254
7. Neuhaus J, Pfeiffer F, Wolburg H et al (2005) Alterations in connexin expression in the bladder of patients with urge symptoms. BJU Int 96:670-676. doi:10.1111/j.1464-410X.2005.05703.x (Pubitemid 41224346)
8. Haferkamp A, Mundhenk J, Bastian PJ et al (2004) Increased expression of connexin 43 in the overactive neurogenic detrusor. Eur Urol 46:799-805. doi:10.1016/ j.eururo.2004.08.020
9. Leung DS, Unsicker K, Reuss B (2002) Expression and developmental regulation of gap junction connexins cx26, cx32, cx43 and cx45 in the rat midbrain-floor. Int J Dev Neurosci 20:63-75. doi:10.1016/S0736-5748(01)00056-9 (Pubitemid 34465462)
10. Trosko JE, Madhukar BV,Chang CC (1993) Endogenousand exogenous modulation of gap junctional intercellular communication: toxicological and pharmacological implications. Life Sci 53:1-19. doi:10.1016/0024-3205(93)90606-4
11. Mori K, Noguchi M, Matsuo M et al (2005) Decreased cellular membrane expression of gap junctional protein, connexin 43, in rat detrusor muscle with chronic partial bladder-outlet obstruction. Urology 65:1254-1258. doi: 10.1016/j.urology.2005.01.043 (Pubitemid 40824941)
12. Schroder A, Uvelius B, Newgreen D et al (2003) Bladder overactivity in mice after 1 week of outlet obstruction. Mainly afferent dysfunction? J Urol 170:1017-1021. doi: 10.1097/01.ju.0000070926.39442.4c (Pubitemid 36999624)
13. Miyazato M, Sugaya K, Nishijima S et al (2008) Changes of bladder activity and glycine levels in the lumbosacral cord after partial bladder-outlet obstruction in rats. Int J Urol 15:843-847. doi:10.1111/j.1442-2042.2008.02079. x
14. Tanaka H, Kakizaki H, Shibata T et al (2003) Effects of chronic blockade of N-methyl-D-aspartate receptors by MK-801 on neuroplasticity of the micturition reflex pathway after partial urethral obstruction in the rat. J Urol 170:1427-1431. doi:10.1097/01.ju.0000074713.69589.4a (Pubitemid 37108176)
15. Knutson T, Edlund C, Fall M et al (2001) BPH with coexisting overactive bladder dysfunction-an everyday urological dilemma. Neurourol Urodyn 20:237-247. doi: 10.1002/nau.1001 (Pubitemid 32377204)