Effects of extracochlear gacyclidine perfusion on tinnitus in humans: A case series

European Archives of Oto-Rhino-Laryngology

Volumn 267, Issue 5, 2010, Pages 691-699

  Wenzel, Gentiana Ioana ^a   Warnecke, Athanasia ^a   Stöver, Timo ^a   Lenarz, Thomas ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Cochlea; Gacyclidine; Local therapy; Round window; Tinnitus

Indexed keywords

GACYCLIDINE; PARACETAMOL;

ADULT; ARTICLE; CLINICAL ARTICLE; COCHLEA FENESTRA; DIZZINESS; DRUG DOSE INCREASE; DRUG TOLERABILITY; FEMALE; HEADACHE; HEAT SENSATION; HUMAN; MALE; PERCEPTION DEAFNESS; PRIORITY JOURNAL; SIDE EFFECT; TINNITUS; TREATMENT RESPONSE; UNILATERAL HEARING LOSS; VERTIGO; VISUAL ANALOG SCALE;

ADMINISTRATION, TOPICAL; ADOLESCENT; ADULT; AUDIOMETRY, PURE-TONE; COCHLEA; CYCLOHEXENES; FEMALE; HEARING LOSS, SENSORINEURAL; HUMANS; MALE; MIDDLE AGED; NEUROPROTECTIVE AGENTS; PIPERIDINES; RECEPTORS, N-METHYL-D-ASPARTATE; ROUND WINDOW, EAR; TINNITUS; YOUNG ADULT;

EID: 77954543459     PISSN: 09374477     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00405-009-1126-1     Document Type: Article

References (61)

1. Andersson G, Lyttkens L (1996) Acupuncture for tinnitus: time to stop? Scand Audiol 25:273-275
2. Chen Z, Ulfendahl M, Ruan R, Tan L, Duan M (2003) Acute treatment of noise trauma with local caroverine application in the guinea pig. Acta Otolaryngol 123:905-909
3. Chen Z, Ulfendahl M, Ruan R, Tan L, Duan M (2004) Protection of auditory function against noise trauma with local caroverine administration in guinea pigs. Hear Res 197:131-136
4. Costa E (1998) From GABAA receptor diversity emerges a unified vision of GABAergic inhibition. Annu Rev Pharmacol Toxicol 38:321-350
5. Czuczwar SJ, Patsalos PN (2001) The new generation of GABA enhancers. Potential in the treatment of epilepsy. CNS Drugs 15:339-350
6. Denk DM, Heinzl H, Franz P, Ehrenberger K (1997) Caroverine in tinnitus treatment. A placebo-controlled blind study. Acta Otolaryngol 117:825-830
7. Dobie RA, Sakai CS, Sullivan MD, Katon WJ, Russo J (1993) Antidepressant treatment of tinnitus patients: report of a randomized clinical trial and clinical prediction of benefit. Am J Otol 14:18-23
8. Duckert LG, Rees TS (1984) Placebo effect in tinnitus management. Otolaryngol Head Neck Surg 92:697-699
9. Ehrenberger K (2005) Topical administration of caroverine in somatic tinnitus treatment: proof-of-concept study. Int Tinnitus J 11:34-37
10. Feldblum S, Arnaud S, Simon M, Rabin O, D'Arbigny P (2000) Efficacy of a new neuroprotective agent, gacyclidine, in a model of rat spinal cord injury. J Neurotrauma 17:1079-1093
11. Galici R, Pinna G, Stephens DN, Schneider HH, Turski L (1998) Tolerance to and dependence on alprazolam are due to changes in GABAa receptor function and are independent of exposure to experimental set-up. Restor Neurol Neurosci 12:233-237
12. Goldstein BA, Shulman A (2003) Tinnitus outcome profile and tinnitus control. Int Tinnitus J 9:26-31
13. Guitton MJ, Caston J, Ruel J, Johnson RM, Pujol R, Puel JL (2003) Salicylate induces tinnitus through activation of cochlear NMDA receptors. J Neurosci 23:3944-3952
14. Henry JA, Schechter MA, Loovis CL, Zaugg TL, Kaelin C, Montero M (2005) Clinical management of tinnitus using a "progressive intervention" approach. J Rehabil Res Dev 42:95-116
15. Hesse G (2008) Neurootologic and psychosomatic habituation therapy. Treatment approaches in chronic tinnitus. HNO 56:686-693
16. Hester TO, Theilman G, Green W, Jones RO (1998) Cyclandelate in the management of tinnitus: a randomized, placebo-controlled study. Otolaryngol Head Neck Surg 118:329-332
17. Hirbec H, Gaviria M, Vignon J (2001) Gacyclidine: a new neuroprotective agent acting at the N-methyl-D-aspartate receptor. CNS Drug Rev 7:172-198
18. Hirbec H, Kamenka JM, Privat A, Vignon J (2001) Characterization of 'non-N-methyl-D-aspartate' binding sites for gacyclidine enantiomers in the rat cerebellar and telencephalic structures. J Neurochem 77:190-201
19. Hirbec H, Mausset AL, Kamenka JM, Privat A, Vignon J (2002) Re-evaluation of phencyclidine low-affinity or "non-NMDA" binding sites. J Neurosci Res 68:305-314
20. Holgers KM, Axelsson A, Pringle I (1994) Ginkgo biloba extract for the treatment of tinnitus. Audiology 33:85-92
21. Hulshof JH, Vermeij P (1987) The effect of nicotinamide on tinnitus: a double-blind controlled study. Clin Otolaryngol Allied Sci 12:211-214
22. Hulshof JH, Vermeij P (1985) The value of carbamazepine in the treatment of tinnitus. ORL J Otorhinolaryngol Relat Spec 47:262-266
23. Hulshof JH, Vermeij P (1986) The value of flunarizine in the treatment of tinnitus. ORL J Otorhinolaryngol Relat Spec 48:33-36
24. Hulshof JH, Vermeij P (1985) The value of tocainide in the treatment of tinnitus. A double-blind controlled study. Arch Otorhinolaryngol 241:279-283
25. Ikonomidou C, Bosch F, Miksa M, Bittigau P, Vockler J, Dikranian K, Tenkova TI, Stefovska V, Turski L, Olney JW (1999) Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science 283:70-74 (Pubitemid 29044848)
26. Johnson RM, Brummett R, Schleuning A (1993) Use of alprazolam for relief of tinnitus. A double-blind study. Arch Otolaryngol Head Neck Surg 119:842-845
27. Kay NJ (1981) Oral chemotherapy in tinnitus. Br J Audiol 15:123-124
28. Kopke RD, Coleman JK, Liu J, Campbell KC, Riffenburgh RH (2002) Candidate's thesis: enhancing intrinsic cochlear stress defenses to reduce noise-induced hearing loss. Laryngoscope 112:1515-1532
29. Krystal JH, D'Souza DC, Mathalon D, Perry E, Belger A, Hoffman R (2003) NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development. Psychopharmacology (Berl) 169:215-233
30. Lenarz T (1986) Treatment of tinnitus with lidocaine and tocainide. Scand Audiol Suppl 26:49-51 (Pubitemid 17229005)
31. Lenarz T, Gulzow J (1985) Tinnitus therapy with lidocaine and tocainide. Laryngol Rhinol Otol (Stuttg) 64:604-608
32. Lepeintre JF, D'Arbigny P, Mathe JF, Vigue B, Loubert G, Delcour J, Kempf C, Tadie M (2004) Neuroprotective effect of gacyclidine. A multicenter double-blind pilot trial in patients with acute traumatic brain injury. Neurochirurgie 50:83-95
33. Moller AR (1997) A double-blind placebo-controlled trial of baclofen in the treatment of tinnitus. Am J Otol 18:268-269
34. Muly SM, Gross JS, Potashner SJ (2004) Noise trauma alters D- [3H]aspartate release and AMPA binding in chinchilla cochlear nucleus. J Neurosci Res 75:585-596
35. Newman CW, Sandridge SA, Jacobson GP (1998) Psychometric adequacy of the tinnitus handicap inventory (THI) for evaluating treatment outcome. J Am Acad Audiol 9:153-160
36. Niedzielski AS, Safieddine S, Wenthold RJ (1997) Molecular analysis of excitatory amino acid receptor expression in the cochlea. Audiol Neurootol 2:79-91
37. Nordang L, Cestreicher E, Arnold W, Anniko M (2000) Glutamate is the afferent neurotransmitter in the human cochlea. Acta Otolaryngol 120:359-362
38. Oestreicher E, Arnold W, Ehrenberger K, Felix D (1998) Memantine suppresses the glutamatergic neurotransmission of mammalian inner hair cells. ORL J Otorhinolaryngol Relat Spec 60:18-21
39. Oestreicher E, Arnold W, Ehrenberger K, Felix D (1999) New approaches for inner ear therapy with glutamate antagonists. Acta Otolaryngol 119:174-178
40. Oestreicher E, Ehrenberger K, Felix D (2002) Different action of memantine and caroverine on glutamatergic transmission in the mammalian cochlea. Adv Otorhinolaryngol 59:18-25
41. Oliver D, Ludwig J, Reisinger E, Zoellner W, Ruppersberg JP, Fakler B (2001) Memantine inhibits efferent cholinergic transmission in the cochlea by blocking nicotinic acetylcholine receptors of outer hair cells. Mol Pharmacol 60:183-189
42. Olney JW (2002) New insights and new issues in developmental neurotoxicology. Neurotoxicology 23:659-668
43. Paaske PB, Pedersen CB, Kjems G, Sam IL (1991) Zinc in the management of tinnitus. Placebo-controlled trial. Ann Otol Rhinol Laryngol 100:647-649
44. Perucca E, Jackson P (1985) A controlled study of the suppression of tinnitus by lidocaine infusion: (relationship of therapeutic effect with serum lidocaine levels). J Laryngol Otol 99:657-661
45. Pujol R, Puel JL (1999) Excitotoxicity, synaptic repair, and functional recovery in the mammalian cochlea: a review of recent findings. Ann N Y Acad Sci 884:249-254
46. Rosenberg SI, Silverstein H, Rowan PT, Olds MJ (1998) Effect of melatonin on tinnitus. Laryngoscope 108:305-310
47. Rowland LM, Astur RS, Jung RE, Bustillo JR, Lauriello J, Yeo RA (2005) Selective cognitive impairments associated with NMDA receptor blockade in humans. Neuropsychopharmacology 30:633-639
48. Schwab B, Lenarz T, Heermann R (2004) Use of the round window micro cath for inner ear therapy-results of a placebocontrolled, prospective study on chronic tinnitus. Laryngorhinootologie 83:164-172
49. Schwarz JB, Gibbons SE, Graham SR, Colbry NL, Guzzo PR, Le VD, Vartanian MG, Kinsora JJ, Lotarski SM, Li Z, Dickerson MR, Su TZ, Weber ML, El-Kattan A, Thorpe AJ, Donevan SD, Taylor CP, Wustrow DJ (2005) Novel cyclopropyl beta-amino acid analogues of pregabalin and gabapentin that target the alpha2-delta protein. J Med Chem 48:3026-3035
50. Sekiya T, Shimamura N, Hatayama T, Suzuki S (2000) Effectiveness of preoperative administration of an N-methyl-D-aspartate antagonist to enhance cochlear neuron resistance to intraoperative traumatic stress: an experimental study. J Neurosurg 93:90-98
51. Simpson JJ, Donaldson I, Davies WE (1998) Use of homeopathy in the treatment of tinnitus. Br J Audiol 32:227-233
52. Soholm B (1998) Clinical improvement of memory and other cognitive functions by Ginkgo biloba: review of relevant literature. Adv Ther 15:54-65
53. Spangler EL, Bresnahan EL, Garofalo P, Muth NJ, Heller B, Ingram DK (1991) NMDA receptor channel antagonism by dizocilpine (MK-801) impairs performance of rats in aversively motivated complex maze tasks. Pharmacol Biochem Behav 40:949-958
54. Stahl SM (2004) Anticonvulsants and the relief of chronic pain: pregabalin and gabapentin as alpha(2)delta ligands at voltagegated calcium channels. J Clin Psychiatry 65:596-597
55. Stoney PJ, Callaghan DE, Walker FS, Stephens SD (1991) A controlled trial of azapropazone in tinnitus. Br J Audiol 25:415-417
56. Sugimoto M, Uchida I, Mashimo T (2003) Local anaesthetics have different mechanisms and sites of action at the recombinant N-methyl-D-aspartate (NMDA) receptors. Br J Pharmacol 138:876-882
57. Sullivan M, Katon W, Russo J, Dobie R, Sakai C (1993) A randomized trial of nortriptyline for severe chronic tinnitus. Effects on depression, disability, and tinnitus symptoms. Arch Intern Med 153:2251-2259
58. Taylor CP (1997) Mechanisms of action of gabapentin. Rev Neurol (Paris) 153(Suppl 1):S39-S45
59. Vandame D, Desmadryl G, Becerril Ortega J, Teigell M, Crouzin N, Buisson A, Privat A, Hirbec H (2007) Comparison of the pharmacological properties of GK11 and MK801, two NMDA receptor antagonists: towards an explanation for the lack of intrinsic neurotoxicity of GK11. J Neurochem 103:1682-1696
60. Westerberg BD, Roberson JB Jr, Stach BA (1996) A double-blind placebo-controlled trial of baclofen in the treatment of tinnitus. Am J Otol 17:896-903
61. Zenner HP, Ruppersberg JP, Busch A (2000) Method for treating diseases of the inner ear using adamantane derivatives. US Patent No. 6,066,652