Insulin-like growth factor-I induced and constitutive arginase activity differs among isolates of Leishmania derived from patients with diverse clinical forms of Leishmania braziliensis infection

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 104, Issue 8, 2010, Pages 566-568

  Vendrame, Célia M V ^a,b   Souza, Luana D ^a   Carvalho, Márcia D T ^a   Salgado, Kátia ^b   Carvalho, Edgar M ^b   Goto, Hiro ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF BAHIA   (Brazil)

Author keywords

Arginase; Cutaneous leishmaniasis; Disseminated leishmaniasis; Insulin like growth factor I; Leishmania braziliensis; Mucosal leishmaniasis

Indexed keywords

ARGINASE; SOMATOMEDIN C;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISSEMINATED LEISHMANIASIS; ENZYME ACTIVITY; HUMAN; LEISHMANIA BRAZILIENSIS; LEISHMANIASIS; MICROBIAL GROWTH; MUCOSAL LEISHMANIASIS; NONHUMAN; PARASITE ISOLATION; SKIN LEISHMANIASIS;

LEISHMANIA BRAZILIENSIS;

EID: 77954537669     PISSN: 00359203     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trstmh.2010.03.007     Document Type: Article

References (6)

1. Schriefer A., Schriefer A.L., Goes-Neto A., Guimaraes L.H., Carvalho L.P., Almeida R.P., et al. Multiclonal Leishmania braziliensis population structure and its clinical implication in a region of endemicity for American tegumentary leishmaniasis. Infect Immun 2004, 72:508-514.
2. Vendrame C.M., Carvalho M.D., Rios F.J., Manuli E.R., Petitto-Assis F., Goto H. Effect of insulin-like growth factor-I on Leishmania amazonensis promastigote arginase activation and reciprocal inhibition of NOS2 pathway in macrophage in vitro. Scand J Immunol 2007, 66:287-296.
3. Goto H., Gomes C.M., Corbett C.E., Monteiro H.P., Gidlund M. Insulin-like growth factor I is a growth-promoting factor for Leishmania promastigotes and amastigotes. Proc Natl Acad Sci USA 1998, 95:13211-13216.
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5. Wanasen N., Soong L. L-arginine metabolism and its impact on host immunity against Leishmania infection. Immunol Res 2008, 41:15-25.
6. Turetz M.L., Machado P.R., Ko A.I., Alves F., Bittencourt A., Almeida R.P., et al. Disseminated leishmaniasis: a new and emerging form of leishmaniasis observed in northeastern Brazil. J Infect Dis 2002, 186:1829-1834.