Nitric oxide modulates recombinant human bone morphogenetic protein-2-induced corticocancellous autograft incorporation: A study in rat intertransverse fusion

European Spine Journal

Volumn 19, Issue 6, 2010, Pages 931-939

  Diwan, Ashish D ^a,c   Khan, Safdar N ^b   Cammisa Jr , Frank P ^a   Sandhu, Harvinder S ^a   Lane, Joseph M ^a,b,c  

^a Department of Molecular Biology and Genetics   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Nitric oxide; Nitric oxide synthase; rhBMP 2; Spinal fusion

Indexed keywords

COLLAGEN SPONGE; DRINKING WATER; N(G) NITROARGININE METHYL ESTER; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOGRAFT; BIOMECHANICS; BONE GRAFT; BONE MATURATION; BONE REMODELING; CANCELLOUS BONE; CONTROLLED STUDY; DRUG ACTIVITY; HISTOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; SPINE FUSION;

ANIMALS; BONE MORPHOGENETIC PROTEIN 2; BONE REMODELING; BONE TRANSPLANTATION; DISEASE MODELS, ANIMAL; GRAFT SURVIVAL; HUMANS; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OSTEOGENESIS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT FUSION PROTEINS; SPINAL FUSION; TRANSPLANTATION, AUTOLOGOUS;

EID: 77954533528     PISSN: 09406719     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00586-009-1263-7     Document Type: Article

References (21)

1. AD Diwan MX Wang D Jang, et al. 2000 Nitric oxide modulates fracture healing J Bone Miner Res 15 2 342 351 10.1359/jbmr.2000.15.2.342 1:CAS:528:DC%2BD3cXhtlGns7w%3D 10703937
2. W Zhu AD Diwan JH Lin, et al. 2001 Nitric oxide synthase isoforms during fracture healing J Bone Miner Res 16 3 535 540 10.1359/jbmr.2001.16.3.535 1:CAS:528:DC%2BD3MXhvFKktrk%3D 11277271
3. W Zhu GA Murrell JH Lin, et al. 2002 Localization of nitric oxide synthases during fracture healing J Bone Miner Res 17 8 1470 1477 10.1359/jbmr.2002.17.8.1470 1:CAS:528:DC%2BD38XmsVWktb4%3D 12162501
4. K Tsuji A Bandyopadhyay BD Harfe, et al. 2006 BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing Nat Genet 38 12 1424 1429 10.1038/ng1916 1:CAS:528:DC%2BD28Xht1CntrfM 17099713 (Pubitemid 44837565)
5. M Murnaghan L McIlmurray M Mushipe, et al. 2005 Time for treating bone fracture using rhBMP-2: a randomised placebo controlled mouse fracture trial J Orthop Res 23 3 625 631 10.1016/j.orthres.2004.12.008 1:CAS:528: DC%2BD2MXktVOjtL0%3D 15885484 (Pubitemid 40631335)
6. DR Sumner TM Turner RM Urban, et al. 2004 Locally delivered rhBMP-2 enhances bone ingrowth and gap healing in a canine model J Orthop Res 22 1 58 65 10.1016/S0736-0266(03)00127-X 1:CAS:528:DC%2BD3sXptlyhs7c%3D 14656660 (Pubitemid 38035446)
7. RW Haid Jr CL Branch Jr JT Alexander, et al. 2004 Posterior lumbar interbody fusion using recombinant human bone morphogenetic protein type 2 with cylindrical interbody cages Spine J 4 5 527 538 10.1016/j.spinee.2004.03.025 15363423 (Pubitemid 40029169)
8. JK Burkus HS Sandhu MF Gornet, et al. 2005 Use of rhBMP-2 in combination with structural cortical allografts: clinical and radiographic outcomes in anterior lumbar spinal surgery J Bone Joint Surg Am 87 6 1205 1212 10.2106/JBJS.D.02532 15930528 (Pubitemid 40756620)
9. AL Jone RW Buchholtz MJ Bosse, et al. 2006 Recombinant human BMP-2 and allograft compared with autogenous bone graft for reconstruction of diaphyseal tibial fractures with cortical defects. A randomized, controlled trial J Bone Joint Surg Am 88 7 1431 1441 10.2106/JBJS.E.00381
10. K Singh JD Smucker SD Boden, et al. 2006 Use of recombinant human bone morphogenetic protein-2 as an adjunct in posterolateral lumbar spine fusion: a prospective CT-scan analysis at one and two years J Spinal Disord Tech 19 6 416 423 10.1097/00024720-200608000-00008 16891977 (Pubitemid 44197593)
11. H Morisue M Matsimoto K Chiba, et al. 2006 A novel hydroxyapatite fiber mesh as a carrier for recombinant human bone morphogenetic protein-2 enhances bone union in rat posterolateral fusion model Spine 31 11 1194 1200 10.1097/01.brs.0000217679.46489.1b 16688031
12. E Carlisle JS Fischgrund 2005 Bone morphogenetic proteins for spinal fusion Spine J 5 6 Suppl 240S 249S 10.1016/j.spinee.2005.02.014 16291119 (Pubitemid 41700067)
13. JN Grauer DA Bomback R Lugo, et al. 2004 Posterolateral lumbar fusions in athymic rats: characterization of a model Spine J 4 3 281 286 10.1016/j.spinee.2003.10.001 15125850 (Pubitemid 38559918)
14. W Zhu BA Rawlins O Boachie-Adjei, et al. 2004 Combined bone morphogenetic protein-2 and -7 gene transfer enhances osteoblastic differentiation and spine fusion in a rodent model J Bone Miner Res 19 12 2021 2032 10.1359/JBMR.040821 1:CAS:528:DC%2BD2cXhtFChtLfK 15537446 (Pubitemid 41103417)
15. ML Salamon PL Althausen MC Gupta, et al. 2003 The effects of BMP-7 in a rat posterolateral intertransverse process fusion model J Spinal Disord Tech 16 1 90 95 12571490
16. DA Bomback JN Grauer R Lugo, et al. 2004 Comparison of posterolateral lumbar fusion rates of Grafton Putty and OP-1 Putty in an athymic rat model Spine 29 15 1612 1617 10.1097/01.BRS.0000132512.53305.A1 15284503 (Pubitemid 39014835)
17. SD Boden L Titus G Hair, et al. 1998 Lumbar spine fusion by local gene therapy with cDNA encoding a novel osteoinductive protein (LMP-1) Spine 23 2486 2492 10.1097/00007632-199812010-00003 1:STN:280:DyaK1M%2FntF2isw%3D%3D 9854747 (Pubitemid 29003522)
18. Wang JC, Davies M, Kanim LEA, Ukatu CJ, Dawson EG, Lieberman JR (2000) Prospective comparison of commercially available demineralized bone matrix for spine fusion. Paper presented at North American Spine Society Meeting; October 25-28, 2000, New Orleans, LA, USA
19. SD Boden JH Schimandle WC Hutton, et al. 1995 An experimental lumbar intertransverse process spinal fusion model. Radiographic, histologic, and biomechanical healing characteristics Spine 20 4 412 420 10.1097/00007632- 199502001-00003 1:STN:280:DyaK2M3ms1SgtA%3D%3D 7747224
20. Boden SD (2002) Overview of the biology of lumbar spine fusion and principles for selecting a bone graft substitute. Spine 27(16 Suppl 1):S26-S31
21. JY Jung AC Lin LM Ramos, et al. 2003 Nitric oxide synthase I mediates osteoclast activity in vitro and in vivo J Cell Biochem 89 3 613 621 10.1002/jcb.10527 1:CAS:528:DC%2BD3sXksVKkur0%3D 12761894 (Pubitemid 36648782)