Detection of differential mitotic cell age in bone marrow CD34+ cells from patients with myelodysplastic syndrome and acute leukemia by analysis of an epigenetic molecular clock DNA signature

Experimental Hematology

Volumn 38, Issue 8, 2010, Pages 661-665

  Mossner, Maximilian ^a   Hopfer, Olaf ^a   Nowak, Daniel ^b   Baldus, Claudia D ^a   Neumann, Uwe ^c   Kmetsch, Anke ^a   Benlasfer, Ouidad ^a   John, Thilo ^a   Perka, Carsten ^a   Thiel, Eckhard ^a   Hofmann, Wolf Karsten ^b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c Department of Oncology and Haematology and BMT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BISULFITE; CD34 ANTIGEN; GENOMIC DNA; TRANSCRIPTION FACTOR NKX2.5;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ARTICLE; BONE MARROW CELL; CD34 SELECTION; CELL AGING; CELL COMPARTMENTALIZATION; CELL DIFFERENTIATION; CHILD; CONTROLLED STUDY; DNA DETERMINATION; EPIGENETICS; HEMATOPOIETIC CELL; HIGH RISK PATIENT; HUMAN; HUMAN CELL; INFANT; MAJOR CLINICAL STUDY; MITOSIS; MOLECULAR CLOCK; MYELODYSPLASTIC SYNDROME; PRIORITY JOURNAL; PROTEIN METHYLATION; PYROSEQUENCING;

ANTIGENS, CD34; BONE MARROW CELLS; CELL AGING; CPG ISLANDS; DNA METHYLATION; DNA, NEOPLASM; HOMEODOMAIN PROTEINS; HUMANS; LEUKEMIA, MYELOID, ACUTE; MITOSIS; MYELODYSPLASTIC SYNDROMES; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; TRANSCRIPTION FACTORS;

EID: 77954533167     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2010.03.022     Document Type: Article

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