Fatal vancomycin- and linezolid-resistant Enterococcus faecium sepsis in a child undergoing allogeneic haematopoietic stem cell transplantation for beta-thalassaemia major

Journal of Medical Microbiology

Volumn 59, Issue 7, 2010, Pages 839-842

  Fossati, Marco ^a   Cappelli, Barbara ^a,b   Biral, Erika ^a,b   Chiesa, Robert ^a,b   Biffi, Alessandra ^a,b   Ossi, Cristina ^a   Moro, Matteo ^a   Cirillo, Daniela Maria ^a   Clementi, Massimo ^a,c   Soliman, Clara ^a   Ciceri, Fabio ^a   Roncarolo, Maria Grazia ^a,b,c   Fumagalli, Luca ^a   Marktel, Sarah ^a,b  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b SAN RAFFAELE SCIENTIFIC INSTITUTE   (Italy)

^c VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; AMIKACIN; AMPHOTERICIN B LIPID COMPLEX; CASPOFUNGIN; CEFTAZIDIME; CIPROFLOXACIN; LEVOFLOXACIN; LINEZOLID; MEROPENEM; PENTAMIDINE; VANCOMYCIN;

ALLOGENEIC STEM CELL TRANSPLANTATION; ANTIBIOTIC SENSITIVITY; ANTIMICROBIAL THERAPY; ARTICLE; BONE MARROW APLASIA; CASE REPORT; CHILD; ENTEROCOCCUS FAECIUM; FATALITY; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; INFECTION; INFECTION CONTROL; PRIORITY JOURNAL; SCHOOL CHILD; SEPSIS; THALASSEMIA MAJOR;

ANTI-BACTERIAL AGENTS; BETA-THALASSEMIA; CHILD; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ENTEROCOCCUS FAECIUM; FATAL OUTCOME; FEMALE; GRAM-POSITIVE BACTERIAL INFECTIONS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; SEPSIS;

EID: 77954521532     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/jmm.0.018598-0     Document Type: Article

References (17)

1. Ardura, M. I., Mejias, A., Katz, K. S., Revell, P., McCracken, G. H., Jr & Sánchez, P. J. (2007). Daptomycin therapy for invasive Gram-positive bacterial infections in children. Pediatr Infect Dis J 26, 1128-1132.
2. Bonora, M. G., Solbiati, M., Stepan, E., Zorzi, A., Luzzani, A., Catania, M. R. & Fontana, R. (2006). Emergence of linezolid resistance in the vancomycin-resistant Enterococcus faecium multilocus sequence typing C1 epidemic lineage. J Clin Microbiol 44, 1153-1155.
3. CDC (2002). Guideline for hand hygiene in health-care settings. Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force. MMWR Recomm Rep 51, 1-45.
4. Cetinkaya, Y., Falk, P. & Mayhall, C. G. (2000). Vancomycin-resistant enterococci. Clin Microbiol Rev 13, 686-707.
5. Cian, F., Luzzati, R., Deiana, M. L., Ferrantelli, N., Tonin, E., Lagatolla, C. & Dolzani, L. (2009). Colonization of the tip of a thoracic catheter by Enterococcus faecalis resistant to vancomycin and linezolid. J Med Microbiol 58, 1118-1121.
6. Deshpande, L. M., Fritsche, T. R., Moet, G. J., Biedenbach, D. J. & Jones, R. N. (2007). Antimicrobial resistance and molecular epidemiology of vancomycin-resistant enterococci from North America and Europe: a report from the SENTRY antimicrobial surveillance program. Diagn Microbiol Infect Dis 58, 163-170.
7. Dutka-Malen, S., Evers, S. & Courvalin, P. (1995). Detection of glycopeptide resistance genotypes and identification to the species level of clinically relevant enterococci by PCR. J Clin Microbiol 33, 1434.
8. Gonzales, R. D., Schreckenberger, P. C., Graham, M. B., Kelkar, S., DenBesten, K. & Quinn, J. P. (2001). Infections due to vancomycin-resistant Enterococcus faecium resistant to linezolid. Lancet 357, 1179. (Pubitemid 32378693)
9. Han, S. H., Chin, B. S., Lee, H. S., Jeong, S. J., Choi, H. K., Kim, C. O., Yong, D., Choi, J. Y., Song, Y. G. & other authors (2009). Vancomycin-resistant enterococci bacteremia: risk factors for mortality and influence of antimicrobial therapy on clinical outcome. J Infect 58, 182-190.
10. Herrero, I. A., Issa, N. C. & Patel, R. (2002). Nosocomial spread of linezolid-resistant, vancomycin-resistant Enterococcus faecium. N Engl J Med 346, 867-869.
11. Jenkins, I. (2007). Linezolid and vancomycin resistant Enterococcus faecium endocarditis: successful treatment with tigecycline and daptomycin. J Hosp Med 2, 343-344.
12. McDonald, L. C. (2006). Trends in antimicrobial resistance in health care-associated pathogens and effect on treatment. Clin Infect Dis 42, S65-S71.
13. Miranda, A. G., Singh, K. V. & Murray, B. E. (1991). DNA fingerprinting of Enterococcus faecium by pulsed-field gel electrophoresis may be a useful epidemiologic tool. J Clin Microbiol 29, 2752-2757.
14. Pankey, G., Ashcraft, D. & Patel, N. (2005). In vitro synergy of daptomycin plus rifampin against Enterococcus faecium resistant to both linezolid and vancomycin. Antimicrob Agents Chemother 49, 5166-5168.
15. Seedat, J., Zick, G., Klare, I., Konstabel, C., Weiler, N. & Sahly, H. (2006). Rapid emergence of resistance to linezolid during linezolid therapy of an Enterococcus faecium infection. Antimicrob Agents Chemother 50, 4217-4219.
16. WHO (2009). WHO Guidelines on Hand Hygiene in Health Care. WHO/IER/PSP/2009/01. Geneva: World Health Organization.
17. Wisplinghoff, H., Bischoff, T., Tallent, S. M., Seifert, H., Wenzel, R. P. & Edmond, M. B. (2004). Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis 39, 309-317.