Reseda luteola L. extract displays antiproliferative and pro-apoptotic activities that are related to its major flavonoids

Phytotherapy Research

Volumn 24, Issue 7, 2010, Pages 1033-1036

  Woelfle, U ^a   Simon Haarhaus, B ^a   Merfort, I ^b   Schempp, Christoph M ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Apigenin; Apoptosis; Luteolin; Reseda luteola L.

Indexed keywords

APIGENIN; FLAVONOID; LUTEOLIN; LUTEOLIN 7 GLUCOSIDE; PLANT EXTRACT; RF 40; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; C BANDING; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MEDICINAL PLANT; PERIPHERAL BLOOD MONONUCLEAR CELL; RESEDA LUTEOLA;

APIGENIN; APOPTOSIS; CELL PROLIFERATION; CELLS, CULTURED; FLAVONES; FLAVONOIDS; GLUCOSIDES; HUMANS; LEUKOCYTES, MONONUCLEAR; LUTEOLIN; MOLECULAR STRUCTURE; PLANT EXTRACTS; RESEDACEAE;

RESEDA; RESEDA LUTEOLA;

EID: 77954518203     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3069     Document Type: Article

References (23)

1. Agullo G, Gamet-Payrastre L, Manenti S, Viala C, Rémésy C, Chap H, Payrastre B. 1997. Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: a comparison with tyrosine kinase and protein kinase C inhibition. Biochem Pharmacol 53: 1649-1657.
2. Casetti F, Jung W, Wölfle U, Reuter J, Neumann K, Gilb B, Wähling A, Wagner S, Merfort I, Schempp CM. 2009 (submitted). Topical application of solubilized Reseda luteola extract inhibits ultraviolet B-induced inflammation in vivo. J Photochem Photobiol B (in press). 2009, 96: 260-265
3. Chen CY, Peng WH, Tsai KD, Hsu SL. 2007. Luteolin suppresses inflammation-associated gene expression by blocking NFkappaB and AP-1 activation pathway in mouse alveolar macrophages. Life Sci 81: 1602-1614.
4. Engel K, Schmidt U, Simon-Haarhaus U, Schempp CM. 2007. Usnea barbata extract prevents ultraviolet-B induced prostaglandin E2 synthesis and COX-2 activation in HaCaT keratinocytes. J Photochem Photobiol (B) 89: 9-14.
5. Fang J, Zhou Q, Shi XL, Jiang BH. 2007. Luteolin inhibits insulinlike growth factor 1 receptor signaling in prostate cancer cells. Carcinogenesis 28: 713-723.
6. Havsteen BH. 2002. The biochemistry and medical significance of the flavonoids. Pharmacol Ther 96: 67-202.
7. Heim KE, Tagliaferro AR, Bobilya DJ. 2002. Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships. J Nutr Biochem 13: 572-584.
8. Horvathova K, Chalupa I, Sebova L, Tothova D, Vachalkova A. 2005. Protective effect of quercetin and luteolin in human melanoma HMB-2 cells. Mutat Res 565: 105-112. (Pubitemid 40127572)
9. Hu C and Kitts DD. 2004. Luteolin and luteolin-7-O-glucoside from dandelion flower suppress iNOS and COX-2 in RAW264.7 cells. Mol Cell Biochem 265: 107-113.
10. Kim SH, Shin KJ, Kim D, Kim YH, Han HS, Lee TG, Kim E, Ryu SH, Suh PG. 2003. Luteolin inhibits the nuclear factor-kappa B transcriptional activity in Rat-1 fibroblasts. Biochem Pharmacol 66: 955-963.
11. Kimata M, Inagaki N, Nagai H. 2000b. Effects of luteolin and other flavonoids on IgE-mediated allergic reactions. Planta Med 66: 25-29.
12. Kimata M, Shichijo M, Miura T, Serizawa I, Inagaki N, Nagai H. 2000a. Effects of luteolin, quercetin and baicalein on immunoglobulin E-mediated mediator release from human cultured mast cells. Clin Exp Allergy 30: 501-508.
13. Lin Y, Shi R, Wang X, Shen HM. 2008. Luteolin, a flavonoid with potential for cancer prevention and therapy. Curr Cancer Drug Targets 8: 634-646.
14. Liu W, Liang NC, Huang RB. 2006. Effect of three flavones on enzyme activity of recombinant human phosphoinositide 3-kinase p110beta catalytic subunit. Zhong Yao Cai 29: 33-36.
15. Merfort I, Heilmann J, Hagedorn-Leweke U, Lippold BC. 1994. In vivo skin penetration studies of camomile flavones. Pharmazie 49: 509-511. (Pubitemid 24240336)
16. Samy RP, Gopalakrishnakone P, Ignacimuthu S. 2006. Antitumor promoting potential of luteolin against 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats. Chem Biol Interact 164: 1-14.
17. Schempp CM, Simon-Haarhaus B, Termeer CC, Simon JC. 2001. Hypericin photo-induced apoptosis of Jurkat cells involves the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and activation of caspase-8. FEBS Lett 493: 26-30.
18. Schempp CM, Wähling A, Lange E. 2004. Method for the production of flavonoid-containing compositions and use thereof. PCT WO 2004/075816 A2
19. Seelinger G, Merfort I, Schempp CM. 2008a. Anti-oxidant, antiinflammatory and anti-allergic activities of luteolin. Planta Med 74: 1667-1677.
20. Seelinger G, Merfort I, Wölfle U, Schempp CM. 2008b. Anticarcinogenic effects of the flavonoid luteolin. Molecules 13: 2628-2651.
21. Tsuji PA and Walle T. 2008. Cytotoxic effects of the dietary flavones chrysin and apigenin in a normal trout liver cell line. Chem Biol Interact 171: 37-44.
22. Wang XG, Chen GY, Chen MP. 2007. Effect of luteolin on COX-2 and mPGES-1 expression in LPS-induced RAW264.7 cells. Zhong Yao Cai 30: 1263-1266.
23. Ziyan L, Yongmei Z, Nan Z, Ning T, Baolin L. 2007. Evaluation of the anti-inflammatory activity of luteolin in experimental animal models. Planta Med 73: 221-226.