Hydroxyurea induced oscillations in twelve patients with polycythemia vera

Haematologica

Volumn 95, Issue 7, 2010, Pages 1227-1229

  Tauscher, Jan ^a   Siege, Fabian ^a   Petrides, Petro E ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Anagrelide; Cyclic hematopoiesis; Fourier analysis; Hydroxyurea; JAK2V617F mutation; Lomb analysis; Periodicity; Platelet oscillations; Polycythemia vera; Spectral analysis; WBC oscillations

Indexed keywords

ACETYLSALICYLIC ACID; ANAGRELIDE; BUSULFAN; HYDROXYUREA; JANUS KINASE 2; SYREA; UNCLASSIFIED DRUG;

ADULT; BLEEDING; CLINICAL ARTICLE; COHORT ANALYSIS; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FEMALE; HEMATOPOIESIS; HUMAN; LETTER; LEUKOCYTE COUNT; LEUKOCYTOSIS; MALE; MATHEMATICAL ANALYSIS; PERIODICITY; PHLEBOTOMY; POLYCYTHEMIA VERA; SIDE EFFECT; SPLEEN DISEASE; SPLENECTOMY; THROMBOCYTE COUNT; THROMBOCYTOSIS; THROMBOEMBOLISM; TREATMENT DURATION; BIOLOGICAL RHYTHM; DRUG EFFECTS;

BIOLOGICAL CLOCKS; FEMALE; HUMANS; HYDROXYUREA; LEUKOCYTE COUNT; MALE; PLATELET COUNT; POLYCYTHEMIA VERA;

EID: 77954466982     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2010.022178     Document Type: Letter

References (9)

1. Pinazzi G, Barbui T. Evidence and expertise in the management of polycythemia vera and essential thrombocythemia. Leukemia. 2008;22(8):1494-502.
2. Spivak J. Polycythemia vera: myths, mechanisms, and management. Blood. 2002;100(13):4272-90.
3. Yarbro J. Mechanism of action of hydroxyurea. Semin Oncol. 1992;19(3 Suppl 9):1-10.
4. Burthem J, Chaudhry MS. Hydroxycarbamide associated platelet count oscillations in a patient with polycythaemia vera. A case report and review of the literature. Platelets. 2008;19(3):234-5.
5. Bennett M, Grunwald AJ. Hydroxyurea and periodicity in myeloproliferative disease. Eur J Haematol. 2001;66(5): 317-23.
6. Steensma DP, Harrison CN, Tefferi A. Hydroxyurea-asso-ciated platelet count oscillations in polycythemia vera: A report of four new cases and a review. Leukemia. 2001; 42(6):1243-53.
7. Tefferi A, Elliott MA, Kao PC, Yoon S, El-Hemaidi I, Pearson TC. Hydroxyurea-induced marked oscillations of platelet counts in patients with polycythemia vera. Blood. 2000;96(4):1582-4.
8. von Schulthess GK, Gessner U. Oscillating platelet counts in healthy individuals: experimental investigation and quantitative evaluation of thrombocytopoietic feedback control. Scand J Haematol. 1986;36(5):473-9.
9. Morley A, King-Smith EA, Stohlman P. Oscillatory nature of hemopoiesis. Hemopoietic Cellular Proliferation. In: Stohlman, P Jr. (Ed.). New York Grune and Stratton, Inc. (1970), 3-14.