Inhibition of DC-SIGN-mediated transmission of human immunodeficiency virus type 1 by Toll-like receptor 3 signalling in breast milk macrophages

Immunology

Volumn 130, Issue 4, 2010, Pages 597-607

  Yagi, Yukie ^a   Watanabe, Eri ^a   Watari, Eiji ^a   Shinya, Eiji ^a   Satomi, Misao ^a   Takeshita, Toshiyuki ^a   Takahashi, Hidemi ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

breast milk macrophages; colostrum early breast milk; dendritic cell specific intercellular adhesion molecule 3 (ICAM3) grabbing nonintegrin (DC SIGN); human immunodeficiency virus type 1 mother to child transmission; Toll like receptor 3; type I interferons

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CD209 ANTIGEN; DOUBLE STRANDED RNA; INTERLEUKIN 4; TOLL LIKE RECEPTOR 3;

ARTICLE; BREAST FEEDING; BREAST MILK; CHILD; CYTOKINE RELEASE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; VERTICAL TRANSMISSION; VIRUS TRANSMISSION;

CELL ADHESION MOLECULES; CELLS, CULTURED; FEMALE; GENE EXPRESSION REGULATION; HIV-1; HUMANS; INTERFERON-ALPHA; INTERFERON-BETA; LECTINS, C-TYPE; LIGANDS; MACROPHAGES; MILK, HUMAN; POLY I-C; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 3;

EID: 77954460693     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2010.03264.x     Document Type: Article

References (21)

1. McIntyre J. Strategies to prevent mother-to-child transmission of HIV. Curr Opin Infect Dis 2006 19 : 33 8.
2. Rousseau CM, Nduati RW, Richardson BA, Steele MS, John-Stewart GC, Mbori-Ngacha DA, Kreiss JK, Overbaugh J. Longitudinal analysis of human immunodeficiency virus type 1 RNA in breast milk and of its relationship to infant infection and maternal disease. J Infect Dis 2003 187 : 741 747.
3. Satomi M, Shimizu M, Shinya E et al. Transmission of macrophage-tropic HIV-1 by breast-milk macrophages via DC-SIGN. J Infect Dis 2005 191 : 174 181.
4. Ichikawa M, Sugita M, Takahashi M, Satomi M, Takeshita T, Araki T, Takahashi H. Breast milk macrophages spontaneously produce granulocyte- macrophage colony-stimulating factor and differentiate into dendritic cells in the presence of exogenous interleukin-4 alone. Immunology 2003 108 : 189 195.
5. Geijtenbeek TB, Kwon DS, Torensma R et al. DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell 2000 100 : 587 597.
6. Semba RD. Mastitis and transmission of human immunodeficiency virus through breast milk. Ann N Y Acad Sci 2000 918 : 156 162.
7. Kantarci S, Koulinska IN, Aboud S, Fawzi WW, Villamor E. Subclinical mastitis, cell-associated HIV-1 shedding in breast milk, and breast-feeding transmission of HIV-1. J Acquir Immune Defic Syndr 2007 46 : 651 654.
8. Lewis P, Nduati R, Kreiss JK, John GC, Richardson BA, Mbori-Ngacha D, Ndinya-Achola J, Overbaugh J. Cell-free human immunodeficiency virus type 1 in breast milk. J Infect Dis 1998 177 : 34 9.
9. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 2001 413 : 732 738.
10. Fujimoto C, Nakagawa Y, Ohara K, Takahashi H. Polyriboinosinic polyribocytidylic acid [poly(I:C)]/TLR3 signaling allows class I processing of exogenous protein and induction of HIV-specific CD8+ cytotoxic T lymphocytes. Int Immunol 2004 16 : 55 63.
11. Shinya E, Owaki A, Shimizu M et al. Endogenously expressed HIV-1 nef down-regulates antigen-presenting molecules, not only class I MHC but also CD1a, in immature dendritic cells. Virology 2004 326 : 79 89.
12. Takeuchi J, Watari E, Shinya E et al. Down-regulation of Toll-like receptor expression in monocyte-derived Langerhans cell-like cells: implications of low-responsiveness to bacterial components in the epidermal Langerhans cells. Biochem Biophys Res Commun 2003 306 : 674 679.
13. Englund G, Theodore TS, Freed EO, Engelman A, Martin MA. Integration is required for productive infection of monocyte-derived macrophages by human immunodeficiency virus type 1. J Virol 1995 69 : 3216 3219.
14. Freed EO, Englund G, Martin MA. Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection. J Virol 1995 69 : 3949 3954.
15. Roy KC, Bandyopadhyay G, Rakshit S, Ray M, Bandyopadhyay S. IL-4 alone without the involvement of GM-CSF transforms human peripheral blood monocytes to a CD1a(dim), CD83(+) myeloid dendritic cell subset. J Cell Sci 2004 117 : 3435 3445.
16. Hayashi F, Means TK, Luster AD. Toll-like receptors stimulate human neutrophil function. Blood 2003 102 : 2660 2669.
17. O'Mahony DS, Pham U, Iyer R, Hawn TR, Liles WC. Differential constitutive and cytokine-modulated expression of human Toll-like receptors in primary neutrophils, monocytes, and macrophages. Int J Med Sci 2008 5 : 1 8.
18. Kong KF, Delroux K, Wang X, Qian F, Arjona A, Malawista SE, Fikrig E, Montgomery RR. Dysregulation of TLR3 impairs the innate immune response to West Nile virus in the elderly. J Virol 2008 82 : 7613 7623.
19. Moore JS, Rahemtulla F, Kent LW, Hall SD, Ikizler MR, Wright PF, Nguyen HH, Jackson S. Oral epithelial cells are susceptible to cell-free and cell-associated HIV-1 infection in vitro. Virology 2003 313 : 343 353.
20. Lyimo MA, Howell AL, Balandya E, Eszterhas SK, Connor RI. Innate factors in human breast milk inhibit cell-free HIV-1 but not cell-associated HIV-1 infection of CD4+ cells. J Acquir Immune Defic Syndr 2009 51 : 117 124.
21. Izquierdo-Useros N, Blanco J, Erkizia I et al. Maturation of blood-derived dendritic cells enhances human immunodeficiency virus type 1 capture and transmission. J Virol 2007 81 : 7559 7570.