Association of gastric cancer incidence with MDR1 gene polymorphism in an ethnic Iranian population

Indian Journal of Cancer

Volumn 47, Issue 3, 2010, Pages 317-321

  Sabahi, Z ^a   Salek, R ^b   Heravi, R E ^a   Mosaffa, F ^a   Avanaki, Z J ^a   Behravan, J ^a  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Gastric cancer; Gene polymorphism; MDR1

Indexed keywords

GENOMIC DNA; MULTIDRUG RESISTANCE PROTEIN 1;

ADULT; AGED; ARTICLE; CANCER INCIDENCE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; ETHNICITY; FEMALE; HUMAN; IRAN; MALE; POLYMERASE CHAIN REACTION; STOMACH CANCER;

ADENOCARCINOMA; ADULT; AGED; DNA MUTATIONAL ANALYSIS; ETHNIC GROUPS; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IRAN; MALE; MIDDLE AGED; P-GLYCOPROTEIN; POLYMORPHISM, GENETIC; STOMACH NEOPLASMS;

EID: 77954437188     PISSN: 0019509X     EISSN: 19984774     Source Type: Journal    
DOI: 10.4103/0019-509X.64723     Document Type: Article

References (17)

1. Arceci RJ. Clinical significance of P-glycoprotein in multidrug resistance malignancies. Blood 1993;81:2215-2222
2. Hartmann G, Kim H, Piquette-Miller M. Regulation of the hepatic multidrug resistance gene expression by endotoxin and infl ammatory cytokines in mice. Int Immunopharmacol 2001;1:189-199
3. Ishikawa T, Hirano H, Onishi Y, Sakurai A, Tarui S. Functional evaluation of ABCB1 (P-glycoprotein) polymorphisms: high-speed screening and structure-activity relationship analyses. Drug Metab Pharmacokinet 2004;19:1-14.
4. Hoffmeyer S, Burk O, von Richter O, Arnold HP, Brockmöller J, Johne A, et al. Functional polymorphism of the human multidrug resistance gene: multiple sequence variant and correlation of one allele with P-glycoprotein expression and activity. Proc Natl Acad Sci U S A 2000;97:3473-3478
5. Hitzl M, Drescher S, van der Kuip H, Schäffeler E, Fischer J, Schwab M, et al. The C3435T mutation in the human MDR1 gene is associated with altered effl ux of the P-glycoprotein substrate rhodamine 123 from CD56 natural killer cell. Pharmacogenetics 2001;11:293-298
6. Kim RB, Leake BF, Choo EF. Identification of functionally variant MDR1 alleles among European Americans and Africans and African Americans. Clin Pharmacol 2001;70:189-199
7. Tanabe M, Ieiri I, Nagata N, Inoue K, Ito S, Kanamori Y, et al. Expression of P-glycoprotein in human placenta: relation to genetic polymorphism of multidrug resistance (MDR) -1 gene. J Pharmacol Exp Ther 2001;297:1137-1143
8. Lahiri DK, Nurnberger JI Jr. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res 1991;19:5444.9.
9. Owen A, Goldring C, Morgan P, Chadwick D, Park BK, Pirmohamed M. Relationship between the C3435T and G2677T (A) polymorphisms in the ABCB1 gene and P-glycoprotein expression in human liver. Br J Clin Pharmacol 2005;59:365-370
10. Malekzadeh R, Sotoudeh M, Derakhshan MH, Mikaeli J, Yazdanbod A, Merat S, et al. Prevalence of gastric precancerous lesions in Ardabil, a high incidence province for gastric adenocarcinoma in the northwest of Iran. J Clin Pathol 2004;57:37-42.
11. Balram C, Sharma A, Sivathasen C, Edmund J, Lee D. Frequency of C3435T single nucleotide MDR1 genetic polymorphism in an Asia population: phenotypic-genotypic correlates. J Clin Pharmacol 2003;56:78-83.
12. Tahara T, Arisawa T, Shibata T, Hirata I, Nakano H. Multi-drug resistance 1 polymorphism is associated with reduced risk of gastric cancer in the Japanese population. J Gastroenterol Hepatol 2007;22:1678-1682
13. Schwab M, Schaeffeler E, Marx C, Fromm MF, Kaskas B, Metzler J, et al. Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis. Gastroenterology 2003;124: 26-33.
14. Farnood A, Naderi N, Moghaddam SJ, Noorinayer B, Firouzi F, Aghazadeh R, et al. The frequency of C3435T MDR1 gene polymorphism in Iranian patients with ulcerative colitis. Int J Colorectal Dis 2007;22:999-1003.
15. Gazouli M, Zacharatos P, Gorgoulis V, Mantzaris G, Papalambros E, Ikonomopoulos J. The C3435T MDR1 gene polymorphism is not associated with susceptibility for ulcerative colitis in Greek population. Gastroenterology 2004;126:367-369
16. Ambudkar SV, Dey S, Hrycyna CA, Ramachandra M, Pastan I, Gottesman MM. Biochemical, cellular and pharmacological aspect of the multidrug transporter. Annu Rev Pharmacol Toxicol 1999;39:361-398
17. Wang BL, Zhai HY, Chen BY, Zhai SP, Yang HY, Chen XP, et al. Clinical relationship between MDR1 gene and gallbladder cancer. Hepatobiliary Pancreat Dis Int 2004;3:296-299