Surface area assessment of the murine intestinal tract as a prerequisite for oral dose translation from mouse to man

Laboratory Animals

Volumn 44, Issue 3, 2010, Pages 176-183

  Casteleyn, C ^a   Rekecki, A ^a   Van Der Aa, A ^b   Simoens, P ^a   Van Den Broeck, W ^a  

^a GHENT UNIVERSITY   (Belgium)

^b ActoGeniX NV   (Belgium)

Author keywords

Dose translation; Intestinal tract; Microvilli; Stereology; Surface area

Indexed keywords

ANIMAL EUTHANASIA; ANIMAL TISSUE; ARTICLE; CECUM; COLON; DENSITY; DUODENUM; FEMALE; GASTROINTESTINAL TRACT; ILEUM; INTESTINE ABSORPTION; INTESTINE EPITHELIUM; JEJUNUM; MALE; MICROVILLUS; MOUSE; NONHUMAN; RECTUM; SCANNING ELECTRON MICROSCOPY; STEREOMETRY; SURFACE PROPERTY; TRANSMISSION ELECTRON MICROSCOPY; ANATOMY AND HISTOLOGY; ANIMAL; DOSE RESPONSE; HUMAN; INBRED MOUSE STRAIN; INTESTINE; INTESTINE CELL; METABOLISM; ORAL DRUG ADMINISTRATION; ORGAN SIZE; PHYSIOLOGY; SPECIES DIFFERENCE; ULTRASTRUCTURE;

ANIMALIA; MURINAE; MUS;

XENOBIOTIC AGENT;

ADMINISTRATION, ORAL; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENTEROCYTES; FEMALE; HUMANS; INTESTINAL ABSORPTION; INTESTINES; MALE; MICE; MICE, INBRED STRAINS; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, ELECTRON, TRANSMISSION; MICROVILLI; ORGAN SIZE; SPECIES SPECIFICITY; XENOBIOTICS;

EID: 77954433490     PISSN: 00236772     EISSN: None     Source Type: Journal    
DOI: 10.1258/la.2009.009112     Document Type: Article

References (32)

1. DeSesso JM, Jacobson CF. Anatomical and physiological parameters affecting gastrointestinal absorption in humans and rats. Food Chem Toxicol 2001;39:209-28
2. Smith MW, Paterson JYF, Peacock MA. A comprehensive description of brush border membrane development applying to enterocytes taken from a wide variety of mammalian species. Comp Biochem Physiol 1984;77A:655-62
3. Hoffmann G. Intestin. In: Hoffmann G, ed. Les Animaux de Laboratoire. Paris: Vigot Frères, 1963
4. Baddeley AJ, Gundersen HJG, Cruz-Orive LM. Estimation of surface area from vertical sections. J Microsc 1986;142:259-76
5. Gundersen HJG, Jensen EB. The efficiency of systematic sampling in stereology and its prediction. J Microsc 1987;147:229-63
6. Howard CV, Reed MG. Unbiased Stereology. Oxford: BIOS Scientific Publishers Limited, 1998
7. Casteleyn CR, Van den Broeck W, Simoens P. Histological characteristics and stereological volume assessment of the ovine tonsils. Vet Immunol Immunopathol 2007;120:124-35
8. Cruz-Orive LM. Stereology of single objects. J Microsc 1997; 186:93-107
9. Casteleyn C, Cornillie P, Simoens P, Van den Broeck W. Stereological assessment of the epithelial surface area of the ovine palatine and pharyngeal tonsils. Anat Histol Embryol 2008;37:366-8
10. Lewis LD, Fordtran JS. Effect of perfusion rate on absorption, surface area, unstirred water layer thickness, permeability, and intraluminal pressure in the rat ileum in vivo. Gastroenterology 1975;68:1509-16
11. Van Ginneken C, Van Meir F, Sys S, Weyns A. Stereologic characteristics of pig small intestine during normal development. Dig Dis Sci 2002;47:868-78
12. De Spiegelaere W, Casteleyn C, Van den Broeck W, Simoens P. Electron microscopic study of the porcine choroid plexus epithelium. Anat Histol Embryol 2008;37:458-63
13. Brown AL Jr. Microvilli of the human jejunal epithelial cells. J Cell Biol 1962;12:623-7
14. Hirsch J, Ahrens EH, Blankenham DH. Measurement of the human intestinal length in vivo and some causes of variation. Gastroenterology 1956;31:274-84
15. Choi YM, Chiou WL. Comparison of in vivo and post-mortem small-intestinal lengths of rats: implication in absorption prediction. Biopharm Drug Dispos 1997;18:271-5
16. Underhill BML. Intestinal length in man. Br Med J 1955;2:1243-6
17. Snyder WS, Cook MJ, Nasset ES, Karhausen LR, Howells GP, Tipton IH. Report of the Task Group on Reference Man. New York: Pergamon, 1975. Retraction in: DeSesso JM, Jacobson CF. Anatomical and physiological parameters affecting gastrointestinal absorption in humans and rats. Food Chem Toxicol 2001;39:209-28
18. Weaver LT, Austin S, Cole TJ. Small intestinal length: a factor essential for gut adaptation. Gut 1991;32:1321-3
19. Ross GA, Mayhew TM. Effects of fasting on mucosal dimensions in the duodenum, jejunum and ileum of the rat. J Anat 1985;142: 191-200
20. Stenling R, Helander HF. Stereological studies on the small intestinal epithelium of the rat. 1. The absorptive cells of the normal duodenum and jejunum. Cell Tissue Res 1981;217:11-21
21. Abe K, Ito T. A qualitative and quantitative morphological study of Peyer's patches of the mouse. Arch Histol Jpn 1977;40:407-20 (Pubitemid 8262504)
22. Mayhew TM. Quantitative ultrastructural study on the responses of microvilli along the small bowel to fasting. J Anat 1987;154:237-43
23. Ross GA, Mayhew TM. Effects of fasting on villi along the small intestine: a stereological approach to the problem of quantifying villus 'shape'. Experientia 1984;40:856-8
24. Effmann EL. Development of the right and left pulmonary arteries: a microangiographic study in the mouse. Invest Radiol 1982;17:529-38
25. Mayhew TM. Striated brush border of intestinal absorptive epithelial cells: stereological studies on microvillous morphology in different adaptive states. J Electron Microsc Tech 1990;16:45-55
26. Dalton AJ. Electron micrography of epithelial cells of gastro-intestinal tract and pancreas. Am J Anat 1951;89:109-33
27. Kararli TT. Comparison of the gastro-intestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals. Biopharm Drug Dispos 1995;16:351-80
28. Niess JH, Reinecker H-C. Dendritic cells in the recognition of intestinal microbiota. Cell Microbiol 2006;8:558-64
29. Ritschel WA. Targeting in the gastro-intestinal tract: new approaches. Methods Fund Exp Clin Pharmacol 1991;13:313-36
30. Reagan-Shaw S, Nihal M, Ahmad N. Dose translation from animal to human studies revisited. FASEB J 2007;22:659-61
31. Harkness JE, Wagner JE. The Biology and Medicine of Rabbits and Rodents, 3rd edn. Philadelphia: Lea and Febiger, 1989
32. Hsu FH, Prueksaritanont T, Lee MG, Chiou WL. The phenomenon and cause of the dose-dependent oral absorption of chlorothiazide in rats: extrapolation to human data based on the body surface area concept. J Pharmacokinet Biopharm 1987;15:369-86 (Pubitemid 18045388)