Prefrontal cortical contributions during discriminative fear conditioning, extinction, and spontaneous recovery in rats

Experimental Brain Research

Volumn 203, Issue 2, 2010, Pages 285-297

  Zelinski, Erin L ^a   Hong, Nancy S ^a   Tyndall, Amanda V ^a   Halsall, Brett ^a   McDonald, Robert J ^a  

^a UNIVERSITY OF LETHBRIDGE   (Canada)

Author keywords

Context discrimination; Emotion; Fear; Generalized anxiety disorder; Medial prefrontal cortex; Orbital prefrontal cortex; Retrieval

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASSOCIATION CORTEX; BRAIN CORTEX LESION; CONDITIONING; CONTROLLED STUDY; DISCRIMINATIVE STIMULUS; FEAR; GENERALIZED ANXIETY DISORDER; LONG EVANS RAT; MALE; MEMORY; NONHUMAN; PATHOLOGY; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT; STIMULUS RESPONSE;

ANALYSIS OF VARIANCE; ANIMALS; ASSOCIATION LEARNING; CONDITIONING (PSYCHOLOGY); DISCRIMINATION LEARNING; EXTINCTION, PSYCHOLOGICAL; FEAR; MALE; PREFRONTAL CORTEX; RATS; RATS, LONG-EVANS;

EID: 77954424575     PISSN: 00144819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00221-010-2228-0     Document Type: Article

References (49)

1. Amaral DG (2003) The amygdala, social behavior, and danger detection. Ann N Y Acad Sci 1000:337-347
2. Amundson JC, Miller RR (2008) CS-US temporal relations in blocking. Learn Behav 36:92-103
3. Antoniadis EA, McDonald RJ (1999) Discriminative fear conditioning to context expressed by multiple measures of fear in the rat. Behav Brain Res 101:1-13
4. Antoniadis EA, McDonald RJ (2000) Amygdala, hippocampus, and discriminative fear conditioning to context. Behav Brain Res 108:1-19
5. Antoniadis EA, McDonald RJ (2001) Amygdala, hippocampus, and unconditioned fear. Exp Brain Res 138:200-209
6. Antoniadis EA, McDonald RJ (2006) Fornix, medial prefrontal cortex, nucleus accumbens and mediodorsal thalamic nucleus: roles in fear context discrimination. Neurobiol Learn Mem 85:71-85
7. Baas JMP, van Ooijen L, Gourdriaan A, Kenemans JL (2008) Failure to condition to a cue is associated with sustained contextual fear. Acta Psychol 127:581-592
8. Bechara A, Damasio H, Damasio AR, Lee GP (1999) DiVerent contributions of the human amygdala and ventromedial prefrontal cortex to decision-making. J Neurosci 19:5473-5481
9. Bouton ME (1993) Context, time, and memory retrieval in the interference paradigms of Pavlovian learning. Psychol Bull 114:80-99
10. Brandon SE, Bombace JC, Falls WA, Wagner AR (1991) Modulation of unconditioned defence reflexes by a putative emotive Pavlovian conditioned stimulus. J Exp Psychol Anim Behav Process 17:312-322
11. Bruchey AK, Shumake J, Gonzalez-Lima G (2007) Network model of fear extinction and renewal functional pathways. Neuroscience 145:423-437
12. den Ouden HE, Friston KJ, Daw ND, McIntosh AR, Stephan KE (2009) A dual role for prediction error in associative learning. Cereb Cortex 19:1175-1185
13. Fogel SM, Smith CT, Beninger RJ (2009) Evidence for 2-stage models of sleep and memory: learning-dependent changes in spindles and theta in rats. Brain Res Bull 79:445-451
14. Grillon C (2002) Startle reactivity and anxiety disorders: aversive conditioning, context, and neurobiology. Biol Psychiatry 52:958-975
15. Hariri AR, Mattay VS, Tessitore A, Kolachana B, Fera F, Goldman D, Egan MF, Weinberger DR (2002) Serotonin transporter genetic variation and the response of the amygdala. Science 297:400-403
16. Hoover WB, Vertes RP (2007) Anatomical analysis of aVerent projection to the medial prefrontal cortex in the rat. Brain Struct Funct 212:149-179
17. Jay TM, Witter MP (1991) Distribution of hippocampal CA1 and subicular efferents in the prefrontal cortex of the rat studied by means of anterograde transport of Phaseolus vulgaris-leucoagglutinin. Comp Neurol 313:574-586
18. Johnson AW, Gallagher M, Holland PC (2009) The basolateral amygdala is critical to the expression of pavlovian and instrumental outcome specific reinforcer devaluation effects. Neuroscience 29:696-704
19. Koch K, Schachzabel C, Wagner G, Reichenbach JR, Sauer H, Schlosser R (2008) The neural correlates of reward-related trialand- error learning: an fMRI study with a probabilistic learning task. Learn Mem 15:728-732
20. Ledoux JE, Muller J (1997) Emotional memory and psychopathology. Phil Trans R Soc Lond B Biol Sci 352:1719-1726
21. Lissek S, Powers AS, McClure EB, Phelps EA, Woldehawariat G, Grillon C, Pine DS (2005) Classical fear conditioning in the anxiety disorders: a meta-analysis. Behav Res Ther 43:1391-1424
22. Maren S (2008) Pavlovian fear conditioning as a behavioural assay for hippocampus and amygdala function: cautions and caveats. Behav Neurosci 28:1661-1666
23. McDonald RJ, King AL, Hong NS (2001) Context-specific interference on reversal learning of a stimulus-response habit. Behav Brain Res 121:149-165
24. McNally RJ (2007) Mechanisms of exposure therapy: how neuroscience can improve psychological treatments for anxiety disorders. Clin Psychol Rev 27:750-759
25. Mennin DS, Heimberg RG, Turk CL, Fresco DM (2005) Preliminary evidence for an emotion dysregulation model of generalized anxiety disorder. Behav Res Therapy 43:1281-1310
26. Milad MR, Quirk GJ (2002) Neurons in medial prefrontal cortex signal memory for fear extinction. Nature 420:70-74
27. Milad MR, Rauch SL (2007) The role of the orbitofrontal cortex in anxiety disorders. Ann N Y Acad Sci 1121:546-561
28. Millan MJ (2003) The neurobiology and control of anxious states. Progr Neurobiol 70:83-244
29. Morgan M, LeDoux JE (1999) Contribution of ventrolateral prefrontal cortex to the acquisition and extinction of conditioned fear in rats. Neurobiol Learn Mem 72:244-251
30. Nutt DJ, Ballenger JC, Sheehan D, Wittchen H (2002) Generalized anxiety disorder: comorbidity, comparative biology and treatment. Int J Neuropsychopharmacol 5:315-325
31. Oler JA, Ramos RL, Penley SC, Markus EJ (2005) Hippocampal and amygdalar involvement in discriminatory place learning. Neuroscience 132:1-12
32. Ostlund SB, Balleine BW (2007) The contribution of orbitofrontal cortex to action selection. Ann N Y Acad Sci 1121:174-192
33. Parvez K, Rosenegger D, Orr M, Martens K, Lukowiak K (2006) Canadian association of neurosciences review: learning at a snail's pace. Can J Neurol Sci 33:347-356
34. Phelps EA, Delgado MR, Nearing KI, LeDoux JE (2004) Extinction learning in humans: role of amygdala and vmPFC. Neuron 16:895-905
35. Quirk GJ, Gehlert DR (2003) Inhibition of the amygdala: key to pathological states? Ann N Y Acad Sci 985:263-272
36. Quirk GJ, Russo GK, Barron JL, Lebron K (2000) The role of ventromedial prefrontal cortex in the recovery of extinguished fear. Neuroscience 20:6225-6231
37. Quirk GJ, Likhtik E, Pelletier JG, Pare D (2003) Stimulation of medial prefrontal cortex decreases the responsiveness of central amygdala output neurons. Neuroscience 23:8800-8807
38. Rajah MN, Ames B, D'Esposito M (2008) Prefrontal contributions to domain-general executive control processes during temporal context retrieval. Neuropsychologia 26:1088-1103
39. Rau V, Fanselow SM (2009) Exposure to a stressor produces a long lasting enhancement of fear learning in rats. Stress 12:125-133
40. Reimer AE, Oliveira AR, Brandao ML (2008) Selective involvement of GABAergic mechanisms of the dorsal periaqueductal gray and inferior colliculus on the memory of the contextual fear as assessed by the fear potentiated startle test. Brain Res Bull 76:545-550
41. Roberts NA, Beer JS, Werner KH, Scabini D, Levens SM, Knight RT, Levenson RW (2004) The impact of orbital prefrontal cortex damage on emotional activation to unanticipated and anticipated acoustic startle stimuli. Cogn Affect Behav Neurosci 4:307-316
42. Rudy JW, Huff NC, Matus-Amut P (2004) Understanding contextual fear conditioning: insights from a two-process model. Neurosci Biobehav Rev 25:675-685
43. Rudy JW, Biedenkapp JC, O'Reilly RC (2005) Prefrontal cortex and the organization of recent and remote memories: an alternative view. Learn Memory 12:445-446
44. Schoenbaum G, Saddoris MP, Stalnaker TA (2007) Reconciling the roles of orbitofrontal cortex in reversal learning and the encoding of outcome expectancies. Ann N Y Acad Sci 1121:320-335
45. Surget A, Belzung C (2008) Involvement of vasopressin in Affective disorders. Eur J Pharmacol 583:340-349
46. Tait DS, Brown VJ (2007) Difficulty overcoming learned non-reward during reversal learning in rats with ibotenic acid lesions of orbital prefrontal cortex. Ann N Y Acad Sci 1121:407-420
47. Tait DS, Marston HM, Shahid M, Brown VJ (2009) Asenapine restores cognitive Xexibility in rats with medial prefrontal cortex lesions. Psychopharmacology 202:295-306
48. Wagner MJ, Smith MA (2008) Shared internal models for feedforward and feedback control. Neuroscience 28:10663-10673
49. Walker DL, Toufexis DJ, Davis M (2003) Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety. Eur J Pharmacol 463:199-216