Ribavirin for Crimean-Congo hemorrhagic fever: Systematic review and meta-analysis

BMC Infectious Diseases

Volumn 10, Issue , 2010, Pages

  Soares Weiser, Karla ^a   Thomas, Sherine ^b   G, Gail T ^c   Garner, Paul ^d  

^a Enhance Reviews Ltd   (United Kingdom)

^b ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

^c PUBLIC HEALTH ENGLAND   (United Kingdom)

^d LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHISTAMINIC AGENT; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; RIBAVIRIN; ANTIVIRUS AGENT;

ADOLESCENT; ADULT; ANEMIA; ANTIBODY RESPONSE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRIMEAN CONGO HEMORRHAGIC FEVER; CRIMEAN CONGO HEMORRHAGIC FEVER VIRUS; DOWN AND BLACK MEDIAN SCORE; DRUG FATALITY; DRUG WITHDRAWAL; ENZYME LINKED IMMUNOSORBENT ASSAY; FATIGUE; HEMOLYTIC ANEMIA; HOSPITALIZATION; HUMAN; LENGTH OF STAY; LOADING DRUG DOSE; MACULOPAPULAR RASH; META ANALYSIS; MORTALITY; NAIRO VIRUS; NAUSEA AND VOMITING; OBSERVATIONAL STUDY; QUALITATIVE ANALYSIS; QUALITY OF LIFE; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL; RECOMMENDED DRUG DOSE; RISK REDUCTION; SCORING SYSTEM; SYSTEMATIC REVIEW; AGED; CHILD; FEMALE; INFANT; MALE; MIDDLE AGED; NEWBORN; PRESCHOOL CHILD; REVIEW; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIVIRAL AGENTS; CHILD; CHILD, PRESCHOOL; FEMALE; HEMORRHAGIC FEVER, CRIMEAN; HUMANS; INFANT; INFANT, NEWBORN; LENGTH OF STAY; MALE; MIDDLE AGED; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RIBAVIRIN; TREATMENT OUTCOME; YOUNG ADULT;

EID: 77954414717     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/1471-2334-10-207     Document Type: Article

References (55)

1. Burt FJ, Spencer DC, Leman PA, Patterson B, Swanepoel R. Investigation of tick-borne viruses as pathogens of humans in South Africa and evidence of Dugbe virus infection in a patient with prolonged thrombocytopenia. Epidemiol Infect 1996, 116:353-361. 10.1017/S0950268800052687, 2271429, 8666081.
2. Clerx JP, Casals J, Bishop D. Structural Characteristics of Nairoviruses (Genus Nairovirus, Bunyaviridae). Journal of General Virology 1981, 55:165-178. 10.1099/0022-1317-55-1-165, 7299367.
3. Papa A MB, Kouidou S, Tang Q, Hang C, Antoniadis A. Genetic Characterization of the M RNA Segment of Crimean Congo Hemorrhagic Fever Virus Strains, China. Emerg Infect Dis 2002, 8:50-53. 10.3201/eid0801.010087, 2730268, 11749748.
4. Papa A BB, Pavlidou V, Papadimitriou E, Pelemis M, Antoniadis A. Genetic detection and isolation of crimean-congo hemorrhagic fever virus, Kosovo, Yugoslavia. Emerg Infect Dis 2002, 8:852-854. 2732509, 12141973.
5. Causey OR, Kemp GE, Madbouly MH, David-West TS. Congo virus from domestic livestock, African hedgehogs, and arthropods in Nigeria. Am J Trop Med Hyg 1970, 19:846-850.
6. Yu-Chen Y, Ling-Xiong K, Ling L, Yu-Qin Z, Feng L, Bao-Jian C, Shou-Yi G. Characteristics of Crimean-Congo hemorrhagic fever virus (Xinjiang strain) in China. Am J Trop Med Hyg 1985, 34:1179-1182.
7. Saluzzo JF, Digoutte JP, Camicas JL, Chauvancy G. Crimean-Congo haemorrhagic fever and Rift valley fever in South-Eastern Mauritania. Lancet 1985, 1(8420):116. 10.1016/S0140-6736(85)92014-8, 2857020.
8. Shepherd AJ, Swanepoel R, Leman PA, Shepherd SP. Field and laboratory investigation of Crimean-Congo haemorrhagic fever virus (Nairovirus, family Bunyaviridae) infection in birds. Trans R Soc Trop Med Hyg 1987, 81:1004-1007. 10.1016/0035-9203(87)90379-8, 3140434.
9. Hoogstraal H. The epidemiology of tick-borne Crimean-Congo hemorrhagic fever in Asia, Europe, and Africa. J Med Entomol 1979, 15:307-417.
10. Swanepoel R, Shepherd AJ, Leman PA, Shepherd SP, McGillivray GM, Erasmus MJ, Searle LA, Gill DE. Epidemiologic and clinical features of Crimean-Congo hemorrhagic fever in southern Africa. Am J Trop Med Hyg 1987, 36:120-132.
11. Van De Wal BW, Joubert JR, Van Eeden PJ, King JB. A nosocomial outbreak of Crimean-Congo haemorrhagic fever at Tygerberg Hospital. Part IV. Preventive and prophylactic measures. South African Medical Journal 1985, 68:729-732.
12. Whitehouse C. Crimean-Congo hemorrhagic fever. Antiviral Res 2004, 64:145-160.
13. Mardani M, Goya M, Zainali M, Jahromi MK. Clinico-epidemiologic feature and outcome analysis of Crimean-Congo haemorraghic fever in Iran (1999-2006). International Journal of Antimicrobial Agents 2007, 29:S280-S280.
14. Ergonul O. Crimean-Congo haemorrhagic fever. Lancet Infectious Diseases 2006, 6:203-214. 10.1016/S1473-3099(06)70435-2, 16554245.
15. Feldman H JS, Klenk HD, Schnittler HJ. Ebola virus: from discovery to vaccine. Nat Immunol 2003, 3:677-685.
16. Schnittler H, Feldman H. Viral hemorrhagic fever--a vascular disease?. Thromb Haemost 2003, 89:967-972.
17. Vasilenko SM, Vassilev TL, Bozadjiev LG, Bineva IL, Kazarov GZ. Specific intravenous immunoglobulin for Crimean-Congo haemorrhagic fever. Lancet 1990, 335:791-792.
18. Witkowski JT RR, Sidwell RW, Simon LN. Design, synthesis, and broad spectrum antiviral activity of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide and related nucleosides. J Med Chem 1972, 15:1150-1154. 10.1021/jm00281a014, 4347550.
19. Watts DM, Ussery MA, Nash D, Peters CJ. Inhibition of Crimean Congo hemorrhagic fever viral infectivity yields in vitro by ribavirin. Am J Trop Med Hyg 1989, 41:581-585.
20. Tignor GH, Hanham CA. Ribavirin efficacy in an in vivo model of Crimean Congo hemorrhagic fever virus (CCHF) infection. Antiviral Res 1993, 22:309-325. 10.1016/0166-3542(93)90040-P, 8279818.
21. Fisher-Hoch S, Khan J, Rehman S, Mirza S, Khursshid M, McCormick J. Congo-Crimean haemorrhagic fever treated with oral ribavirin. Lancet 1995, 346:472-475. 10.1016/S0140-6736(95)91323-8, 7637481.
22. Mardani M, Jahromi MK, Naieni KH, Zeinali M. The efficacy of oral ribavirin in the treatment of Crimean-Congo hemorrhagic fever in Iran. Clinical Infectious Diseases 2003, 36:1613-1618. 10.1086/375058, 12802764.
23. Ergonul O, Celikbas A, Dokuzoguz B, Eren S, Baykam N, Esener H. Characteristics of patients with Crimean-Congo hemorrhagic fever in a recent outbreak in Turkey and impact of oral ribavirin therapy. Clin Infect Dis 2004, 39:284-287. 10.1086/422000, 15307042.
24. Johnsen E, Jorgensen HA. Effectiveness of second generation antipsychotics: A systematic review of randomized trials. BMC Psychiatry 2008, 8:31. 10.1186/1471-244X-8-31, 2386457, 18439263.
25. Maltezou HC, Andonova L, Andraghetti R, Bouloy M, Ergonul O, Jongejan F, Kalvatchev N, Nichol S, Niedrig M, Platonov A, Thomson G, Leitmeyer K, Zeller K. Crimean-Congo hemorrhagic fever in Europe: current situation calls for preparedness. Eurosurveillance 2010, 15(10).
26. Cochrane Handbook for Systematic Reviews of Interventions 2008, Chichester: John Wiley & Sons LTD, 1.
27. Downs SH, Black N. The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health 1998, 52:377-384. 10.1136/jech.52.6.377, 1756728, 9764259.
28. Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, Schunemann HJ. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 2008, 336:924-926. 10.1136/bmj.39489.470347.AD, 18436948.
29. Borenstein M, Hedges LV, Higgins JPT, Rothstein HR. Introduction to Meta-Analysis 2009, Chichester: John Wiley & Sons LTD.
30. Cochran W. The combination of estimates from different experiments. Biometrics 1954, 10:101-129.
31. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003, 327:557-560. 10.1136/bmj.327.7414.557, 192859, 12958120.
32. Ioannidis JP, Patsopoulos NA, Evangelou E. Uncertainty in heterogeneity estimates in meta-analyses. BMJ 2007, 335:914-916. 10.1136/bmj.39343.408449.80, 17974687.
33. Koksal I, Yilmaz G, Aksoy F, Aydin H, Yavuz I, Iskender S, Akcay K, Erensoy S, Caylan R, Aydin K. The efficacy of ribavirin in the treatment of Crimean-Congo hemorrhagic fever in Eastern Black Sea region in Turkey. Journal of Clinical Virology 2009, Corrected Proof.
34. Salehi H. A comparative study on the effect of ribaverin with and without IVIG (Intravenous imuneglobuliu) in treatment of Crimean-congo hemorrhagic Fever (CCHF). Journal of Mazandaran University of Medical Sciences 2004, 14:33-38.
35. Alavi-Naini R, Moghtaderi A, Koohpayeh HR, Sharifi-Mood B, Naderi M, Metanat M, Izadi M. Crimean-Congo hemorrhagic fever in Southeast of Iran. Journal of Infection 2006, 52:378-382. 10.1016/j.jinf.2005.07.015, 16182370.
36. Bodur H, Erbay A, Akinci E, Onguru P, Bayazit N, Eren S, Kubar A. Effect of Oral Ribavirin Treatment to the Viral Load and Progress of the Disease in Crimean Congo Hemorrhagic Fever. Abstracts of the Interscience Conference on Antimicrobial Agents and Chemotherapy 2008, 48:713-714.
37. Cevik MA, Elaldi N, Akinci E, Onguru P, Erbay A, Buzgan T, Uzun R, Kubar A, Bodur H. A preliminary study to evaluate the effect of intravenous ribavirin treatment on survival rates in Crimean-Congo hemorrhagic fever. Journal of Infection 2008, 57:350-351. 10.1016/j.jinf.2008.07.007, 18722669.
38. Elaldi N, Bodur H, Ascioglu S, Celikbas A, Ozkurt Z, Vahaboglu H, Leblebicioglu H, Yilmaz N, Engin A, Sencan M, et al. Efficacy of oral ribavirin treatment in Crimean-Congo haemorrhagic fever: A quasi-experimental study from Turkey. Journal of Infection 2009, 58:238-244. 10.1016/j.jinf.2009.01.014, 19246100.
39. Ergonul O, Celikbas A, Baykam N, Eren S, Dokuzoguz B. Analysis of risk-factors among patients with Crimean-Congo haemorrhagic fever virus infection: severity criteria revisited. Clin Microbiol Infect 2006, 12:551-554. 10.1111/j.1469-0691.2006.01445.x, 16700704.
40. Ertugrul B, Uyar Y, Yavas K, Turan C, Oncu S, Saylak O, Carhan A, Ozturk B, Erol N, Sakarya S. An outbreak of Crimean-Congo hemorrhagic fever in western Anatolia, Turkey. Int J Infect Dis 2009, 13(6):e431-6. 10.1016/j.ijid.2009.02.011, 19409826.
41. Fisgin NT, Ergonul O, Doganci L, Tulek N. The role of ribavirin in the therapy of crimean-congo hemorrhagic fever: Early use is promising. European Journal of Clinical Microbiology and Infectious Diseases 2009, 28:929-933.
42. Nadeem M, Ali N, Anwar M, Hussain I, Mohammad T, Hayee A. A comparision of clinical diagnosis and serological diagnosis in an epidemic of Crimean-Congo Haemorrhagic Fever. Pakistan Journal of Medical Sciences 2003, 19:247-251.
43. Ozkurt Z, Kiki H, Erol S, Erdem F, Yilmaz N, Partak M, Gundogdu M, Tasyaran MA. Crimean-Congo hemorrhagic fever in Eastern Turkey: clinical features, risk factors and efficacy of ribavirin therapy. Journal of Infection 2006, 52:207-215. 10.1016/j.jinf.2005.05.003, 15953646.
44. Ergonul O, Zeller H, Celikbas A, Dokuzoguz B. The lack of Crimean-Congo hemorrhagic fever virus antibodies in healthcare workers in an endemic region. International Journal of Infectious Diseases 2007, 11:48-51. 10.1016/j.ijid.2005.10.009, 16600655.
45. Midilli K, Gargili A, Ergonul O, Sengoz G, Ozturk R, Bakar M, Jongejan F. Imported Crimean-Congo hemorrhagic fever cases in Istanbul. BMC infectious diseases 2007, 7:54. 10.1186/1471-2334-7-54, 1905914, 17553137.
46. Sharifi-Mood B, Mardani M, Keshtkar-Jahromi M, Rahnavardi M, Hatami H, Metanat M. Clinical and epidemiologic features of Crimean-Congo hemorrhagic fever among children and adolescents from southeastern Iran. Pediatric Infectious Disease Journal 2008, 27:561-563. 10.1097/INF.0b013e3181673c28, 18434934.
47. Sharifi-Mood B, Metanat M, Ghorbani-Vaghei A, Fayyaz-Jahani F, Akrami E. The outcome of patients with Crimean-Congo hemorrhagic fever in Zahedan, southeast of Iran: a comparative study. Archives of Iranian medicine 2009, 12:151-153.
48. Ayten K, Kemalettin O, Serpil E, Mehmet P. Crimean-Congo haemorrhagic fever virus infection in eastern Turkey. The second International Congress of Central Asia Infectious Diseases (ICCAID); Almaty, Kazakhstan 2008, , http://www.iccaid.org
49. Izadi S, Salehi M. Evaluation of the efficacy of ribavirin therapy on survival of Crimean-Congo hemorrhagic fever patients: A case-control study. Japanese Journal of Infectious Diseases 2009, 62:11-15.
50. Jamil B, Hasan RS, Sarwari AR, Burton J, Hewson R, Clegg C. Crimean-Congo hemorrhagic fever: Experience at a tertiary care hospital in Karachi, Pakistan. Transactions of the Royal Society of Tropical Medicine and Hygiene 2005, 99:577-584. 10.1016/j.trstmh.2005.03.002, 15935414.
51. Sannikova IV, Kliushnikov Iu I, Popov PN, Sysoliatina GV, Evchenko Iu M, Shenetts KV, Popov VA, Marchukova LN. [Clinico-epidemiological characterization of Crimean haemorrhagic fever in Stavropol' region]. Zh Mikrobiol Epidemiol Immunobiol 2001, 89-92.
52. Sheikh AS, Sheikh AA, Sheikh NS, Rafi US, Asif M, Afridi F, Malik MT. Bi-annual surge of Crimean-Congo haemorrhagic fever (CCHF): A five-year experience. International Journal of Infectious Diseases 2005, 9:37-42. 10.1016/j.ijid.2004.02.007, 15696649.
53. Egger M, Schneider M, Davey Smith G. Spurious precision? Meta-analysis of observational studies. BMJ 1998, 316:140-144. 2665367, 9462324.
54. Formenty P, Schnepf G, Gonzalez-Martin F, Bi Z. International surveillance and control of Crimean-Congo hemorrhagic fever outbreaks. Crimean Congo hemorrhagic fever: a global perspective 2007, 295-303. Springer, Dordrecht, the Netherlands, Ergonul O, Whitehouse CA.
55. Application for inclusion of ribavirin in the WHO Model List of Essential Medicines. , http://archives.who.int/eml/expcom/expcom15/applications/newmed/ribaravin/ribavirin.pdf