Micronuclei and other nuclear anomalies levels in exfoliated buccal cells and DNA damage in leukocytes of patients with polycystic ovary syndrome

Journal of B.U.ON.

Volumn 15, Issue 2, 2010, Pages 337-339

  Nersesyan, Armen ^a   Chobanyan, N ^b  

^a National Center of Oncology   (Armenia)

^b AMERICAN UNIVERSITY   (United States)

Author keywords

Comet assay; DNA damage; Exfoliated cells; Leukocytes; Micronuclei; Polycystic ovary syndrome

Indexed keywords

DNA;

ADULT; ARTICLE; CELL NUCLEUS; CHEEK; CHROMOSOME ABERRATION; CLINICAL ARTICLE; COMET ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; FEMALE; GENOTOXICITY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LEUKOCYTE; MICRONUCLEUS; OVARY POLYCYSTIC DISEASE; SOMATIC CELL;

ADULT; CELL NUCLEUS; DNA DAMAGE; DNA, NEOPLASM; FEMALE; HIRSUTISM; HUMANS; LEUKOCYTES; LUTEINIZING HORMONE; MICRONUCLEUS TESTS; MOUTH MUCOSA; POLYCYSTIC OVARY SYNDROME; REFERENCE VALUES; TESTOSTERONE;

EID: 77954390442     PISSN: 11070625     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Daniilidis A, Dinas K. Long term health consequences of polycystic ovarian syndrome: a review analysis. Hippokratia 2009; 13: 90-92.
2. Dolyan GG. Evaluation of hirsutism in sterile Armenian women. In: Okoev GG (Ed): Actual Problems of Endocrinology. Luys Publishing House, Yerevan, 1999, pp 51-78.
3. Yesilada E, Sahin I, Ozcan H, Yildirim IH, Yologlu S, Taskapan C. Increased micro-nucleus frequencies in peripheral blood lymphocytes in women with polycystic ovary syndrome. Eur J Endocrinol 2006; 154: 563-598.
4. Moran LJ, Noakes M, Clifton PM, Norman RJ, Fenech MF. Genome instability is increased in lymphocytes of women with polycystic ovary syndrome and is correlated with insulin resistance. Mutat Res 2008; 639: 55-63.
5. Nersesyan A, Martirosyan A, Parsadanyan G, Zalinyan G. Chromosomal aberrations level in peripheral blood lymphocytes of women with polycystic ovary syndrome. J BUON 2006; 11: 477-480. (Pubitemid 46729862)
6. Bonassi S, Biasotti B, Kirsch-Volders M et al. State of the art survey of the buccal micronucleus assay-a first stage in the HUMN(XL) project initiative. Mutagenesis 2009; 24: 295-302.
7. Ferriman D, Gallway JD. Clinical assessment of body hair growth in women. J Clin Endocrinol Metab 1961; 21: 1440-1447.
8. Nersesyan AK, Zalinyan GG, Vartazaryan NS, Arutyunyan RM. Micronucleus level in exfoliated buccal mucosa cells of women with hirsutism. Central Eur J Occup Envir Health 2001; 7: 39-44.
9. Nersesyan A, Stopper H. Genotoxic activity of four newly synthesized pyrrolin-2-one derivatives. J BUON 2003; 8: 357-363. (Pubitemid 38660088)
10. Nersesyan AK, Collins AR. Possible genotoxic activity of extracts of Bryonia alba roots on human lymphocytes and transformed cells. Neoplasma 2002; 49: 114-116.
11. Kuşçu NK, Var A. Oxidative stress but not endothelial dysfunction exists in non-obese, young group of patients with polycystic ovary syndrome. Acta Obstet Gynecol Scand 2009; 88: 612-617.
12. Karadeniz M, Erdoǧan M, Tamsel S et al. Oxidative stress markers in young patients with polycystic ovary syndrome, and the relationship between insulin resistances. Exp Clin Endocrinol Diabetes 2008; 116: 231-235. (Pubitemid 351600585)
13. Knasmüller S, Nersesyan A, Misik M et al. Use of conventional and -omics based methods for health claims of dietary antioxidants: a critical overview. Br J Nutr 2008; 99E (Suppl 1): ES3-52.
14. Holland AJ, Cleveland DW. Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Nat Rev Mol Cell Biol 2009; 10: 478-487.