Intrahepatic IgG/IgM plasma cells ratio helps in classifying autoimmune liver diseases

Digestive and Liver Disease

Volumn 42, Issue 8, 2010, Pages 585-592

  Cabibi, Daniela ^a   Tarantino, Giuseppe ^a   Barbaria, Francesco ^a   Campione, Maria ^a   Craxì, Antonio ^a   Di Marco, Vito ^a  

^a UNIVERSITY OF PALERMO   (Italy)

Author keywords

Autoimmune cholangitis; Autoimmune hepatitis; IgG plasma cells; IgM plasma cells; Immunostaining; Liver biopsy; Overlap syndromes; Portal infiltrate; Primary biliary cirrhosis

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; GAMMA GLUTAMYLTRANSFERASE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MITOCHONDRION ANTIBODY; AUTOANTIBODY;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; AUTOIMMUNE CHOLANGITIS; AUTOIMMUNE DISEASE; AUTOIMMUNE HEPATITIS; AUTOIMMUNE LIVER DISEASE; BILE DUCT; CELL COUNT; CHOLANGITIS; CLINICAL FEATURE; DEMOGRAPHY; DISEASE CLASSIFICATION; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GRANULE CELL; GRANULOMA; HEPATITIS C; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; LIVER BIOPSY; LIVER DISEASE; MAJOR CLINICAL STUDY; MALE; OVERLAP SYNDROME; PLASMA CELL; PORTAL VEIN; PRIMARY BILIARY CIRRHOSIS; PRIMARY SCLEROSING CHOLANGITIS; PRIORITY JOURNAL; SEROLOGY; AGED; BILIARY CIRRHOSIS; BIOPSY; BLOOD; CLASSIFICATION; IMMUNOLOGY; LIVER; METABOLISM; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; SCLEROSING CHOLANGITIS; SEX DIFFERENCE;

ADULT; AGED; ALANINE TRANSAMINASE; ALKALINE PHOSPHATASE; AUTOANTIBODIES; AUTOIMMUNE DISEASES; BILE DUCTS; BIOPSY; CHOLANGITIS; CHOLANGITIS, SCLEROSING; FEMALE; GAMMA-GLUTAMYLTRANSFERASE; HEPATITIS C; HEPATITIS, AUTOIMMUNE; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LIVER; LIVER CIRRHOSIS, BILIARY; MALE; MIDDLE AGED; PLASMA CELLS; SEX FACTORS;

EID: 77954386058     PISSN: 15908658     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dld.2009.12.006     Document Type: Article

References (20)

1. Batts K.P., Ludwig J. Histopathology of autoimmune hepatitis, primary biliary cirrhosis and primary sclerosing cholangitis. Autoimmune liver diseases 1998, 115-140. Elsevier, Amsterdam. 2nd ed. E.L. Krawitt, R.H. Wiesner, M. Nishioka (Eds.).
2. Rust C., Beuers U. Overlap syndromes among autoimmune liver diseases. World J Gastroenterol 2008, 14:3368-3373.
3. Beuers U. Hepatic overlap syndromes. J Hepatol 2005, 42:S93-S99.
4. Beuers U., Rust C. Overlap syndromes. Semin Liver Dis 2005, 25:311-320.
5. Hirshfield G.M., Heathcote E.J. Antimitochondrial antibody-negative primary biliary cirrhosis. Clin Liver Dis 2008, 12:323-331.
6. Hiramatsu K., Aoyama H., Zen Y., et al. Proposal of a new staging and grading system of the liver for primary biliary cirrhosis. Histopathology 2006, 49:466-478.
7. Portmann B.C., Nakanuma Y. Diseases of the bile ducts. Pathology of the liver 2001, 435-506. Churchill Livingstone, London. 4th ed. R.N.M. MacSween, A.D. Burt, B.C. Portmann, K.G. Ishak, P.J. Scheuer, P.P. Anthody (Eds.).
8. Milne D.S., Horne C.H. Immunoglobulin classes in biopsies of autoimmune liver disease. Histopathology 1990, 16:283-286.
9. Daniels J.A., Torbenson M., Anders R.A., et al. Immunostaining of plasma cells in primary biliary cirrhosis. Am J Clin Pathol 2009, 131:243-249.
10. Romero-Gómez M., Wichmann I., Crespo J., et al. Serum immunological profile in patients with chronic autoimmune cholestasis. Am J Gastroenterol 2004, 99:2150-2157.
11. Kikuchi K., Lian Z.-X., Yang G.-X., et al. Bacterial CpG induces hyper-IgM production in CD27 memory B cells in primary biliary cirrhosis. Gastroenterology 2004, 128:304-312.
12. Chapman R.W. Role of immune factors in the pathogenesis of primary sclerosing cholangitis. Semin Liver Dis 1991, 11:1-4.
13. Diseases of the liver and biliary system 1997, 239-252. Blackwell Science Ltd, Oxford. 10th ed. S. Sherlock, J. Dooley (Eds.).
14. Liver biopsy interpretation 2000, 166-167. W.B. Saunders Co. Ltd, London. 6th ed. P.J. Scheuer, J.H. Lefkowitch (Eds.).
15. Alvarez F., Berg P.A., Bianchi F.B., et al. International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol 1999, 31:929-938.
16. LaRusso N.F., Shneider B.L., Black D., et al. Primary sclerosing cholangitis: summary of a workshop. Hepatology 2006, 44:746-764.
17. Talwalkar J.A., Keach J.C., Angulo P., et al. Overlap of autoimmune hepatitis and primary biliary cirrhosis: an evaluation of a modified scoring system. Am J Gastroenterol 2002, 97:1191-1197.
18. Sato Y., Harada K., Sudo Y., et al. Autoimmune hepatitis associated with bile duct injury resembling chronic non-suppurative destructive cholangitis. Pathol Int 2002, 52:478-482.
19. Wiesener R.H., La Russo N.F., Ludwig J., et al. Comparison of the clinico-pathological features of primary sclerosing cholangitis and primary biliary cirrhosis. Gastroenterology 1985, 88:108-114.
20. Nakanuma Y., Ohta G. Quantitation of hepatic granuloma and epithelioid cells in primary biliary cirrhosis. Hepatology 1983, 3:423-427.