Membrane topology of human AGPAT3 (LPAAT3)

Biochemical and Biophysical Research Communications

Volumn 397, Issue 4, 2010, Pages 661-667

  Schmidt, John A ^a   Yvone, Griselda Metta ^a   Brown, William J ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

1 Acylglycerol 3 phosphate O acyltransferase; AGPAT3; Golgi complex; LPAAT3; Lysophosphatidic acid acyltransferase; Membrane topology

Indexed keywords

1 ACYLGLYCEROPHOSPHATE ACYLTRANSFERASE; ACYLTRANSFERASE; LYSOPHOSPHATIDIC ACID; PHOSPHOLIPID; PROTEIN AGPAT3; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CYTOPLASM; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; GOLGI COMPLEX; HUMAN; HUMAN CELL; MULTIGENE FAMILY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN MOTIF;

ACYLTRANSFERASES; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; CELL MEMBRANE; CELLS, CULTURED; CYTOPLASM; ENDOPLASMIC RETICULUM; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT;

EID: 77954385191     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.05.149     Document Type: Article

References (27)

1. Shindou H., Shimizu T. Acyl-CoA:lysophospholipid acyltransferases. J. Biol. Chem. 2009, 284:1-5.
2. Hishikawa D., Shindou H., Kobayashi S., Nakanishi H., Taguchi R., et al. Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity. Proc. Natl. Acad. Sci. USA 2008, 105:2830-2835.
3. Sukumaran S., Barnes R.I., Garg A., Agarwal A.K. Functional characterization of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 10/glycerol-3-phosphate acyltransferase isoform 3. J. Mol. Endocrinol. 2009, 42:469-478.
4. H. Shindou, D. Hishikawa, T. Harayama, K. Yuki, T. Shimizu , Recent progress on acyl CoA: lysophospholipid acyltransferase research, J. Lipid. Res. (2009) (Suppl. 50): S46-S51.
5. Bankaitis V.A. The Cirque du Soleil of Golgi membrane dynamics. J. Cell. Biol. 2009, 186:169-171.
6. Brown W.J., Chambers K., Doody A. Phospholipase A2 (PLA2) enzymes in membrane trafficking: mediators of membrane shape and function. Traffic 2003, 4:214-221.
7. Schmidt J.A., Brown W.J. Lysophosphatidic acid acyltransferase 3 regulates Golgi complex structure and function. J. Cell. Biol. 2009, 186:211-218.
8. Yuki K., Shindou H., Hishikawa D., Shimizu T. Characterization of mouse lysophosphatidic acid acyltransferase 3: an enzyme with dual functions in the testis. J. Lipid Res. 2009, 50:860-869.
9. Lewin T.M., Wang P., Coleman R.A. Analysis of amino acid motifs diagnostic for the sn-glycerol-3-phosphate acyltransferase reaction. Biochemistry 1999, 38:5764-5771.
10. Turnbull A.P., Rafferty J.B., Sedelnikova S.E., Slabas A.R., Schierer T.P., et al. Analysis of the structure, substrate specificity, and mechanism of squash glycerol-3-phosphate (1)-acyltransferase. Structure 2001, 9:347-353.
11. Yamashita A., Nakanishi H., Suzuki H., Kamata R., Tanaka K., et al. Topology of acyltransferase motifs and substrate specificity and accessibility in 1-acyl-sn-glycero-3-phosphate acyltransferase 1. Biochim. Biophys. Acta 2007, 1771:1202-1215.
12. Stone S.J., Levin M.C., Farese R.V. Membrane topology and identification of key functional amino acid residues of murine acyl-CoA:diacylglycerol acyltransferase-2. J. Biol. Chem. 2006, 281:40273-40282.
13. Horton P., Nakai K. Better prediction of protein cellular localization sites with the k nearest neighbors classifier. Proc. Int. Conf. Intell. Syst. Mol. Biol. 1997, 5:147-152.
14. Tusnady G.E., Simon I. The HMMTOP transmembrane topology prediction server. Bioinformatics 2001, 17:849-850.
15. von Heijne G. Membrane protein structure prediction hydrophobicity analysis and the positive-inside rule. J. Mol. Biol. 1992, 225:487-494.
16. Mitaku S., Hirokawa T., Tsuji T. Amphiphilicity index of polar amino acids as an aid in the characterization of amino acid preference at membrane-water interfaces. Bioinformatics 2002, 18:608-616.
17. Hoffman K., Stoffel W. TMbase - a database of membrane spanning protein segments. Biol. Chem. Hoppe-Seyler 1993, 374:166.
18. S.J. Johns, TOPO2, transmembrane protein display software, Available from: http://www.sacs.ucsf.edu/TOPO2/.
19. Bonifacino J.S., Glick B.S. The mechanisms of vesicle budding and fusion. Cell 2004, 116:153-166.
20. Lorenz H., Hailey D.W., Lippincott-Schwartz J. Fluorescence protease protection of GFP chimeras to reveal protein topology and subcellular localization. Nat. Methods 2006, 3:205-210.
21. Lorenz H., Hailey D.W., Lippincott-Schwartz J. Addressing membrane protein topology using the fluorescence protease protection (FPP) assay. Methods Mol. Biol. 2008, 440:227-233.
22. Chambers K., Judson B., Brown W.J. A unique lysophospholipid acyltransferase (LPAT) antagonist, CI-976, affects secretory and endocytic membrane trafficking pathways. J. Cell. Sci. 2005, 118:3061-3071.
23. Drecktrah D., Chambers K., Racoosin E.L., Cluett E.B., Gucwa A., et al. Inhibition of a Golgi complex lysophospholipid acyltransferase induces membrane tubule formation and retrograde trafficking. Mol. Biol. Cell. 2003, 14:3459-3469.
24. Kooijman E.E., Chupin V., de Kruijff B., Burger K.N. Modulation of membrane curvature by phosphatidic acid and lysophosphatidic acid. Traffic 2003, 4:162-174.
25. Asp L., Kartberg F., Fernandez-Rodriguez J., Smedh M., Elsner M., et al. Early stages of Golgi vesicle and tubule formation require diacylglycerol. Mol. Biol. Cell. 2009, 20:780-790.
26. Bard F., Malhotra V. The formation of TGN-to-plasma-membrane transport carriers. Annu. Rev. Cell. Dev. Biol. 2006, 22:439-455.
27. Gallop J.L., McMahon H.T. BAR domains and membrane curvature: bringing your curves to the BAR. Biochem. Soc. Symp. 2005, 223:231.